B Cells Drive MHC Class I-Restricted CD4 T Cells to Induce Spontaneous Central Nervous System Autoimmunity

Multiple sclerosis (MS) is an inflammatory, demyelinating CNS disease believed to be mediated by CD4 T cells specific for CNS self-antigens. CD8 T cells are also implicated in MS but their function is not well understood. MS lesions are heterogeneous and may reflect variation in the contribution of...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of immunology (1950) 2022-11, Vol.209 (10), p.1880-1891
Hauptverfasser:	Matter, Aubry L, Liggitt, Denny, Goverman, Joan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity CD4-Positive T-Lymphocytes Central Nervous System Encephalomyelitis, Autoimmune, Experimental Mice Mice, Transgenic Multiple Sclerosis Receptors, Antigen, T-Cell
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!