Double-Stranded RNA Induces Mortality in an MDA5-Mediated Type I Interferonopathy Model

Gain-of-function mutations in the viral dsRNA sensor melanoma differentiation-associated protein 5 (MDA5) lead to autoimmune IFNopathies, including Singleton-Merten syndrome (SMS) and Aicardi-Goutières syndrome. However, much remains unclear regarding the mechanism of disease progression and how ext...

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Veröffentlicht in:	The Journal of immunology (1950) 2022-12, Vol.209 (11), p.2093-2103
Hauptverfasser:	Emralino, Francine Lianne, Satoh, Saya, Sakai, Nobuhiro, Takami, Masamichi, Takeuchi, Fumihiko, Yan, Nan, Rutsch, Frank, Fujita, Takashi, Kato, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases of the Nervous System Dental Enamel Hypoplasia Humans Interferon-beta Interferon-Induced Helicase, IFIH1 - genetics Mice Poly I-C RNA, Double-Stranded
Online-Zugang:	Volltext
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