SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy

Disorganization of the basic contractile unit of muscle cells, i.e., the sarcomeres, leads to suboptimal force generation and is a hallmark of muscle atrophy. Here, we demonstrate that the nuclear role of SENP7 deSUMOylase is pivotal for sarcomere organization. SENP7 expression is temporally upregul...

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Veröffentlicht in:Cell reports (Cambridge) 2022-11, Vol.41 (8), p.111702-111702, Article 111702
Hauptverfasser: Amrute-Nayak, Mamta, Gand, Luis Vincens, Khan, Bushra, Holler, Tim, Kefalakes, Ekaterini, Kosanke, Maike, Kraft, Theresia, Nayak, Arnab
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Sprache:eng
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