Comparison of 2 medium cutoff dialyzers versus on‐line hemodiafiltration regarding depurative ability and albumin loss: An uncontrolled clinical research

Background Hemodialysis (HD) techniques that best remove molecules in the middle to high molecular weight range are on‐line hemodiafiltration (OL‐HDF) and HD with medium cut‐off (MCO) membranes. The aim of this study was to compare efficacy and safety of OL‐HDF with FxCordiax HDF 800™, with HD with 2 MCO dialyzers: Theranova 500® and the new Elisio 21HX™ dialyzer. Methods Fourteen patients following treatment with OL‐HDF using FxCordiax HDF 800™ were randomized to receive a consecutive 1‐week HD treatment with Theranova 500® and Elisio 21HX™.The reduction rate (RR) of differently sized molecules was compared, as well as the variation rate in molecules smaller than 1000, detected by nuclear magnetic resonance based chemometrics (metabolomics). Albumin loss in dialysate was quantified. Results Lower RRs were found for molecules around 20 000 with Elisio 21HX™ compared to OL‐ HDF (RR prolactin 58.5% versus 66.7%, p = 0.034; RR Kappa light chain 63.1% versus 71.8%, p = 0.010). Albumin loss per session was higher with Theranova 500® than with OL‐HDF and with Elisio 21HX™ (2249.9 ± 714.1 mg, 815.2 ± 474.0 mg, 442.9 ± 135.9 mg, p