Stepwise synthesis of 2,6-difunctionalized ethyl pyrazolo[1,5- a ]pyrimidine-3-carboxylate via site-selective cross-coupling reactions: experimental and computational studies

A variety of novel disubstituted 2-(alknyl, aryl and arylamine)-6-alkynylpyrazolo[1,5- ]pyrimidine derivatives was prepared sequential site-selective cross-coupling reactions from 2,6-dibromopyrazolo[1,5- ]pyrimidine 3. The regio-controlled Sonogashira-type coupling of 3 with a wide range of termina...

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Veröffentlicht in:	Organic & biomolecular chemistry 2022-12, Vol.20 (48), p.9684-9697
Hauptverfasser:	Messaoudi, Chaima, Jismy, Badr, Jacquemin, Johan, Allouchi, Hassan, M'Rabet, Hédi, Abarbri, Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Amines Aromatic compounds Carboxylic Acids Catalysis Chemical reactions Computer applications Cross coupling Organic compounds Pyrimidines Regioselectivity Selectivity
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