Significance of spread through air spaces in small cell lung cancer
Purpose Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). Nevertheless, little is known about the role of STAS in small cell lung cancer (SCLC). We sought to determine whether STAS has a significant effect on recurrence a...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2023-07, Vol.149 (8), p.5301-5308 |
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| container_title | Journal of cancer research and clinical oncology |
| container_volume | 149 |
| creator | Han, Lu Huang, Zhida Zhang, Jing Chen, Yan Wang, Jue Xiong, Yicheng Yao, Wangchao Hou, Likun Zhang, Liping Yu, Huansha Song, Nan Zhang, Zhonghong Zhu, Yuming |
| description | Purpose
Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). Nevertheless, little is known about the role of STAS in small cell lung cancer (SCLC). We sought to determine whether STAS has a significant effect on recurrence among SCLC patients.
Methods
We collected clinical and follow-up information from 181 resected stage I–III SCLC patients and compared overall survival (OS) and disease-free survival (DFS) between the patients with or without STAS using the Kaplan‒Meier method. To explore the effect of STAS on recurrence, a competing-risk analysis was conducted.
Results
Among 181 SCLC patients, STAS was observed in 56 (30.94%) patients, and 125 (69.06%) patients did not have STAS. Furthermore, 33 (18.23%) patients had recurrence, including 12 patients with brain metastases. Patients with STAS had worse DFS. The cumulative incidence of any recurrence was higher in patients with STAS than in those without STAS. Univariate and multivariate competing-risk regression analyses revealed that sublobar resection and STAS were independent risk factors for SCLC recurrence (
p
= 0.009 and
p
= 0.029 for multivariate analysis, respectively).
Conclusion
SCLC patients with STAS have worse DFS than SCLC patients without STAS. STAS is an independent prognostic factor in SCLC patients. |
| doi_str_mv | 10.1007/s00432-022-04462-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2739430645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2837642768</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a7a61a59df7be33fd8bd5c0d8553df89cd835087cbf59063b85bac4db43a3aed3</originalsourceid><addsrcrecordid>eNp9kM1OAyEYRYnR2Fp9ARdmEjduRoGPv1maxqpJExfqmjDAtNO0MxU6C9-mz9Ink_6oiQsXQCDnXr4chC4JviUYy7uIMQOaY5oWY4Lm6gj1yfaJAPBj1MdEkpxTInroLMYZTncu6SnqgWBEFFz20ei1njR1VVvTWJ-1VRaXwRu3Wa-moe0m083a1GGzjktjfczqJosLM59n1qdt3jWTbBcM5-ikMvPoLw7nAL2PHt6GT_n45fF5eD_OLUi-yo00ghheuEqWHqByqnTcYqc4B1epwjoFHCtpy4oXWECpeGkscyUDA8Y7GKCbfe8ytB-djyu9qON2GNP4touaSigYYMF4Qq__oLO2C02aTlMFUjAqhUoU3VM2tDEGX-llqBcmfGqC9day3lvWybLeWdbb0NWhuisX3v1EvrUmAPZAslk3Ex9-__6n9gvsVonO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2837642768</pqid></control><display><type>article</type><title>Significance of spread through air spaces in small cell lung cancer</title><source>SpringerLink Journals - AutoHoldings</source><creator>Han, Lu ; Huang, Zhida ; Zhang, Jing ; Chen, Yan ; Wang, Jue ; Xiong, Yicheng ; Yao, Wangchao ; Hou, Likun ; Zhang, Liping ; Yu, Huansha ; Song, Nan ; Zhang, Zhonghong ; Zhu, Yuming</creator><creatorcontrib>Han, Lu ; Huang, Zhida ; Zhang, Jing ; Chen, Yan ; Wang, Jue ; Xiong, Yicheng ; Yao, Wangchao ; Hou, Likun ; Zhang, Liping ; Yu, Huansha ; Song, Nan ; Zhang, Zhonghong ; Zhu, Yuming</creatorcontrib><description>Purpose
Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). Nevertheless, little is known about the role of STAS in small cell lung cancer (SCLC). We sought to determine whether STAS has a significant effect on recurrence among SCLC patients.
Methods
We collected clinical and follow-up information from 181 resected stage I–III SCLC patients and compared overall survival (OS) and disease-free survival (DFS) between the patients with or without STAS using the Kaplan‒Meier method. To explore the effect of STAS on recurrence, a competing-risk analysis was conducted.
Results
Among 181 SCLC patients, STAS was observed in 56 (30.94%) patients, and 125 (69.06%) patients did not have STAS. Furthermore, 33 (18.23%) patients had recurrence, including 12 patients with brain metastases. Patients with STAS had worse DFS. The cumulative incidence of any recurrence was higher in patients with STAS than in those without STAS. Univariate and multivariate competing-risk regression analyses revealed that sublobar resection and STAS were independent risk factors for SCLC recurrence (
p
= 0.009 and
p
= 0.029 for multivariate analysis, respectively).
Conclusion
SCLC patients with STAS have worse DFS than SCLC patients without STAS. STAS is an independent prognostic factor in SCLC patients.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-022-04462-8</identifier><identifier>PMID: 36416957</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer Research ; Hematology ; Internal Medicine ; Lung cancer ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Multivariate analysis ; Non-small cell lung carcinoma ; Oncology ; Risk factors ; Small cell lung carcinoma</subject><ispartof>Journal of cancer research and clinical oncology, 2023-07, Vol.149 (8), p.5301-5308</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a7a61a59df7be33fd8bd5c0d8553df89cd835087cbf59063b85bac4db43a3aed3</citedby><cites>FETCH-LOGICAL-c375t-a7a61a59df7be33fd8bd5c0d8553df89cd835087cbf59063b85bac4db43a3aed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-022-04462-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-022-04462-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36416957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Lu</creatorcontrib><creatorcontrib>Huang, Zhida</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Xiong, Yicheng</creatorcontrib><creatorcontrib>Yao, Wangchao</creatorcontrib><creatorcontrib>Hou, Likun</creatorcontrib><creatorcontrib>Zhang, Liping</creatorcontrib><creatorcontrib>Yu, Huansha</creatorcontrib><creatorcontrib>Song, Nan</creatorcontrib><creatorcontrib>Zhang, Zhonghong</creatorcontrib><creatorcontrib>Zhu, Yuming</creatorcontrib><title>Significance of spread through air spaces in small cell lung cancer</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). Nevertheless, little is known about the role of STAS in small cell lung cancer (SCLC). We sought to determine whether STAS has a significant effect on recurrence among SCLC patients.
Methods
We collected clinical and follow-up information from 181 resected stage I–III SCLC patients and compared overall survival (OS) and disease-free survival (DFS) between the patients with or without STAS using the Kaplan‒Meier method. To explore the effect of STAS on recurrence, a competing-risk analysis was conducted.
Results
Among 181 SCLC patients, STAS was observed in 56 (30.94%) patients, and 125 (69.06%) patients did not have STAS. Furthermore, 33 (18.23%) patients had recurrence, including 12 patients with brain metastases. Patients with STAS had worse DFS. The cumulative incidence of any recurrence was higher in patients with STAS than in those without STAS. Univariate and multivariate competing-risk regression analyses revealed that sublobar resection and STAS were independent risk factors for SCLC recurrence (
p
= 0.009 and
p
= 0.029 for multivariate analysis, respectively).
Conclusion
SCLC patients with STAS have worse DFS than SCLC patients without STAS. STAS is an independent prognostic factor in SCLC patients.</description><subject>Cancer Research</subject><subject>Hematology</subject><subject>Internal Medicine</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Multivariate analysis</subject><subject>Non-small cell lung carcinoma</subject><subject>Oncology</subject><subject>Risk factors</subject><subject>Small cell lung carcinoma</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kM1OAyEYRYnR2Fp9ARdmEjduRoGPv1maxqpJExfqmjDAtNO0MxU6C9-mz9Ink_6oiQsXQCDnXr4chC4JviUYy7uIMQOaY5oWY4Lm6gj1yfaJAPBj1MdEkpxTInroLMYZTncu6SnqgWBEFFz20ei1njR1VVvTWJ-1VRaXwRu3Wa-moe0m083a1GGzjktjfczqJosLM59n1qdt3jWTbBcM5-ikMvPoLw7nAL2PHt6GT_n45fF5eD_OLUi-yo00ghheuEqWHqByqnTcYqc4B1epwjoFHCtpy4oXWECpeGkscyUDA8Y7GKCbfe8ytB-djyu9qON2GNP4touaSigYYMF4Qq__oLO2C02aTlMFUjAqhUoU3VM2tDEGX-llqBcmfGqC9day3lvWybLeWdbb0NWhuisX3v1EvrUmAPZAslk3Ex9-__6n9gvsVonO</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Han, Lu</creator><creator>Huang, Zhida</creator><creator>Zhang, Jing</creator><creator>Chen, Yan</creator><creator>Wang, Jue</creator><creator>Xiong, Yicheng</creator><creator>Yao, Wangchao</creator><creator>Hou, Likun</creator><creator>Zhang, Liping</creator><creator>Yu, Huansha</creator><creator>Song, Nan</creator><creator>Zhang, Zhonghong</creator><creator>Zhu, Yuming</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20230701</creationdate><title>Significance of spread through air spaces in small cell lung cancer</title><author>Han, Lu ; Huang, Zhida ; Zhang, Jing ; Chen, Yan ; Wang, Jue ; Xiong, Yicheng ; Yao, Wangchao ; Hou, Likun ; Zhang, Liping ; Yu, Huansha ; Song, Nan ; Zhang, Zhonghong ; Zhu, Yuming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a7a61a59df7be33fd8bd5c0d8553df89cd835087cbf59063b85bac4db43a3aed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer Research</topic><topic>Hematology</topic><topic>Internal Medicine</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Multivariate analysis</topic><topic>Non-small cell lung carcinoma</topic><topic>Oncology</topic><topic>Risk factors</topic><topic>Small cell lung carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Lu</creatorcontrib><creatorcontrib>Huang, Zhida</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Wang, Jue</creatorcontrib><creatorcontrib>Xiong, Yicheng</creatorcontrib><creatorcontrib>Yao, Wangchao</creatorcontrib><creatorcontrib>Hou, Likun</creatorcontrib><creatorcontrib>Zhang, Liping</creatorcontrib><creatorcontrib>Yu, Huansha</creatorcontrib><creatorcontrib>Song, Nan</creatorcontrib><creatorcontrib>Zhang, Zhonghong</creatorcontrib><creatorcontrib>Zhu, Yuming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Lu</au><au>Huang, Zhida</au><au>Zhang, Jing</au><au>Chen, Yan</au><au>Wang, Jue</au><au>Xiong, Yicheng</au><au>Yao, Wangchao</au><au>Hou, Likun</au><au>Zhang, Liping</au><au>Yu, Huansha</au><au>Song, Nan</au><au>Zhang, Zhonghong</au><au>Zhu, Yuming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of spread through air spaces in small cell lung cancer</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>149</volume><issue>8</issue><spage>5301</spage><epage>5308</epage><pages>5301-5308</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). Nevertheless, little is known about the role of STAS in small cell lung cancer (SCLC). We sought to determine whether STAS has a significant effect on recurrence among SCLC patients.
Methods
We collected clinical and follow-up information from 181 resected stage I–III SCLC patients and compared overall survival (OS) and disease-free survival (DFS) between the patients with or without STAS using the Kaplan‒Meier method. To explore the effect of STAS on recurrence, a competing-risk analysis was conducted.
Results
Among 181 SCLC patients, STAS was observed in 56 (30.94%) patients, and 125 (69.06%) patients did not have STAS. Furthermore, 33 (18.23%) patients had recurrence, including 12 patients with brain metastases. Patients with STAS had worse DFS. The cumulative incidence of any recurrence was higher in patients with STAS than in those without STAS. Univariate and multivariate competing-risk regression analyses revealed that sublobar resection and STAS were independent risk factors for SCLC recurrence (
p
= 0.009 and
p
= 0.029 for multivariate analysis, respectively).
Conclusion
SCLC patients with STAS have worse DFS than SCLC patients without STAS. STAS is an independent prognostic factor in SCLC patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36416957</pmid><doi>10.1007/s00432-022-04462-8</doi><tpages>8</tpages></addata></record> |
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| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Cancer Research Hematology Internal Medicine Lung cancer Medical prognosis Medicine Medicine & Public Health Metastases Multivariate analysis Non-small cell lung carcinoma Oncology Risk factors Small cell lung carcinoma |
| title | Significance of spread through air spaces in small cell lung cancer |
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