The genetic alterations of rectal neuroendocrine tumor and indications for therapy and prognosis: a systematic review

Neuroendocrine tumors (NETs) are a type of rare tumor that can occur at multiple organs. Rectal NETs are the most common NETs in gastrointestinal tract. Due to the rarity of rectal NETs in rectal cancer, the molecular features and the correlation with patient therapeutic response and prognosis have...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2023, Vol.70(2), pp.197-205
Hauptverfasser:	Li, Ke, Liu, Ying, Han, Junge, Gui, Jianhua, Zhang, Xiuyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenomatous polyposis coli Biomarkers, Tumor BRAF Copy number Gastrointestinal tract Humans Medical prognosis MEK inhibitors Metastases MLH1 protein MSH2 protein MSH6 protein Mutation Myc protein Neuroendocrine cancer Neuroendocrine tumor Neuroendocrine Tumors p53 Protein Prognosis Proto-Oncogene Proteins B-raf - genetics PTEN protein Rectal Rectal Neoplasms - genetics Rectum Risk factors Therapeutic applications Therapeutic targets
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