Epigenetic regulation of gastrointestinal cancers mediated by long non-coding RNAs
Long noncoding RNAs (lncRNAs), as well-known modulator of the epigenetic processes, have been shown to contribute to normal cellular physiological and pathological conditions such as cancer. Through the interaction with epigenetic regulators, an aberrant regulation of gene expression can be resulted...
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| Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2022-01, Vol.35 (4), p.359-377 |
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| container_title | Cancer biomarkers : section A of Disease markers |
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| creator | Akbari, Abolfazl Abbasi, Somayeh Borumandnia, Nasrin Eshkiki, Zahra Shokati Sedaghat, Meghdad Tabaeian, Seidamir Pasha Kashani, Amirhossein Faghihi Talebi, Atefeh |
| description | Long noncoding RNAs (lncRNAs), as well-known modulator of the epigenetic processes, have been shown to contribute to normal cellular physiological and pathological conditions such as cancer. Through the interaction with epigenetic regulators, an aberrant regulation of gene expression can be resulted due to their dysregulation, which in turn, can be involved in tumorigenesis. In the present study, we reviewed the lncRNAs’ function and mechanisms that contributed to aberrant epigenetic regulation, which is directly related to gastrointestinal cancer (GI) development and progression. Findings indicated that epigenetic alterations may involve in tumorigenesis and are valuable biomarkers in case of diagnosing, assessing of risk factors, and predicting of GI cancers. This review summarized the accumulated evidence for biological and clinical application to use lncRNAs in GI cancers, including colorectal, gastric, oral, liver, pancreatic and oesophageal cancer. |
| doi_str_mv | 10.3233/CBM-220142 |
| format | Article |
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Through the interaction with epigenetic regulators, an aberrant regulation of gene expression can be resulted due to their dysregulation, which in turn, can be involved in tumorigenesis. In the present study, we reviewed the lncRNAs’ function and mechanisms that contributed to aberrant epigenetic regulation, which is directly related to gastrointestinal cancer (GI) development and progression. Findings indicated that epigenetic alterations may involve in tumorigenesis and are valuable biomarkers in case of diagnosing, assessing of risk factors, and predicting of GI cancers. This review summarized the accumulated evidence for biological and clinical application to use lncRNAs in GI cancers, including colorectal, gastric, oral, liver, pancreatic and oesophageal cancer.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-220142</identifier><identifier>PMID: 36404536</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Bioaccumulation ; Biomarkers ; Cancer ; Carcinogenesis - genetics ; Epigenesis, Genetic ; Epigenetics ; Esophageal cancer ; Gastrointestinal cancer ; Gastrointestinal Neoplasms - genetics ; Gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; Liver cancer ; Non-coding RNA ; Pancreatic cancer ; Risk analysis ; Risk factors ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Tumorigenesis</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2022-01, Vol.35 (4), p.359-377</ispartof><rights>2022 – IOS Press. All rights reserved.</rights><rights>Copyright IOS Press BV 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-b8a881dba98e1fb992472d23f7f9e85b636e4b50c4729bbf2688f117017f59693</citedby><cites>FETCH-LOGICAL-c413t-b8a881dba98e1fb992472d23f7f9e85b636e4b50c4729bbf2688f117017f59693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.3233/CBM-220142$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.3233/CBM-220142$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.3233/CBM-220142?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36404536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akbari, Abolfazl</creatorcontrib><creatorcontrib>Abbasi, Somayeh</creatorcontrib><creatorcontrib>Borumandnia, Nasrin</creatorcontrib><creatorcontrib>Eshkiki, Zahra Shokati</creatorcontrib><creatorcontrib>Sedaghat, Meghdad</creatorcontrib><creatorcontrib>Tabaeian, Seidamir Pasha</creatorcontrib><creatorcontrib>Kashani, Amirhossein Faghihi</creatorcontrib><creatorcontrib>Talebi, Atefeh</creatorcontrib><title>Epigenetic regulation of gastrointestinal cancers mediated by long non-coding RNAs</title><title>Cancer biomarkers : section A of Disease markers</title><addtitle>Cancer Biomark</addtitle><description>Long noncoding RNAs (lncRNAs), as well-known modulator of the epigenetic processes, have been shown to contribute to normal cellular physiological and pathological conditions such as cancer. Through the interaction with epigenetic regulators, an aberrant regulation of gene expression can be resulted due to their dysregulation, which in turn, can be involved in tumorigenesis. In the present study, we reviewed the lncRNAs’ function and mechanisms that contributed to aberrant epigenetic regulation, which is directly related to gastrointestinal cancer (GI) development and progression. Findings indicated that epigenetic alterations may involve in tumorigenesis and are valuable biomarkers in case of diagnosing, assessing of risk factors, and predicting of GI cancers. This review summarized the accumulated evidence for biological and clinical application to use lncRNAs in GI cancers, including colorectal, gastric, oral, liver, pancreatic and oesophageal cancer.</description><subject>Bioaccumulation</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Carcinogenesis - genetics</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Esophageal cancer</subject><subject>Gastrointestinal cancer</subject><subject>Gastrointestinal Neoplasms - genetics</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Non-coding RNA</subject><subject>Pancreatic cancer</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Tumorigenesis</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLxDAQx4Morq-LH0AKHhShmmebHNfFF6wKoueSpEnJ0k3WpD347c2yPkA8zTD8-M_MD4BjBC8JJuRqdv1YYgwRxVtgD_GalZwJvJ17VtMSIkYmYD-lBYSUICx2wYRUFFJGqj3wcrNynfFmcLqIpht7Objgi2CLTqYhBucHkwbnZV9o6bWJqVia1snBtIX6KPrgu8IHX-rQuty-PE3TIdixsk_m6KsegLfbm9fZfTl_vnuYTeelpogMpeKSc9QqKbhBVgmBaY1bTGxtheFMVaQyVDGo81goZXHFuUWohqi2TFSCHIDzTe4qhvcxX9ksXdKm76U3YUwNrgmnAhFGM3r6B12EMean1hRjgkBR80xdbCgdQ0rR2GYV3VLGjwbBZm26yaabjekMn3xFjiob-UG_1WbgbAMk2Znfff9EfQLOj4M9</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Akbari, Abolfazl</creator><creator>Abbasi, Somayeh</creator><creator>Borumandnia, Nasrin</creator><creator>Eshkiki, Zahra Shokati</creator><creator>Sedaghat, Meghdad</creator><creator>Tabaeian, Seidamir Pasha</creator><creator>Kashani, Amirhossein Faghihi</creator><creator>Talebi, Atefeh</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220101</creationdate><title>Epigenetic regulation of gastrointestinal cancers mediated by long non-coding RNAs</title><author>Akbari, Abolfazl ; Abbasi, Somayeh ; Borumandnia, Nasrin ; Eshkiki, Zahra Shokati ; Sedaghat, Meghdad ; Tabaeian, Seidamir Pasha ; Kashani, Amirhossein Faghihi ; Talebi, Atefeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-b8a881dba98e1fb992472d23f7f9e85b636e4b50c4729bbf2688f117017f59693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bioaccumulation</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Carcinogenesis - genetics</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Esophageal cancer</topic><topic>Gastrointestinal cancer</topic><topic>Gastrointestinal Neoplasms - genetics</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Non-coding RNA</topic><topic>Pancreatic cancer</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbari, Abolfazl</creatorcontrib><creatorcontrib>Abbasi, Somayeh</creatorcontrib><creatorcontrib>Borumandnia, Nasrin</creatorcontrib><creatorcontrib>Eshkiki, Zahra Shokati</creatorcontrib><creatorcontrib>Sedaghat, Meghdad</creatorcontrib><creatorcontrib>Tabaeian, Seidamir Pasha</creatorcontrib><creatorcontrib>Kashani, Amirhossein Faghihi</creatorcontrib><creatorcontrib>Talebi, Atefeh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Akbari, Abolfazl</au><au>Abbasi, Somayeh</au><au>Borumandnia, Nasrin</au><au>Eshkiki, Zahra Shokati</au><au>Sedaghat, Meghdad</au><au>Tabaeian, Seidamir Pasha</au><au>Kashani, Amirhossein Faghihi</au><au>Talebi, Atefeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigenetic regulation of gastrointestinal cancers mediated by long non-coding RNAs</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>35</volume><issue>4</issue><spage>359</spage><epage>377</epage><pages>359-377</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>Long noncoding RNAs (lncRNAs), as well-known modulator of the epigenetic processes, have been shown to contribute to normal cellular physiological and pathological conditions such as cancer. Through the interaction with epigenetic regulators, an aberrant regulation of gene expression can be resulted due to their dysregulation, which in turn, can be involved in tumorigenesis. In the present study, we reviewed the lncRNAs’ function and mechanisms that contributed to aberrant epigenetic regulation, which is directly related to gastrointestinal cancer (GI) development and progression. Findings indicated that epigenetic alterations may involve in tumorigenesis and are valuable biomarkers in case of diagnosing, assessing of risk factors, and predicting of GI cancers. This review summarized the accumulated evidence for biological and clinical application to use lncRNAs in GI cancers, including colorectal, gastric, oral, liver, pancreatic and oesophageal cancer.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36404536</pmid><doi>10.3233/CBM-220142</doi><tpages>19</tpages></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Bioaccumulation Biomarkers Cancer Carcinogenesis - genetics Epigenesis, Genetic Epigenetics Esophageal cancer Gastrointestinal cancer Gastrointestinal Neoplasms - genetics Gene expression Gene Expression Regulation, Neoplastic Humans Liver cancer Non-coding RNA Pancreatic cancer Risk analysis Risk factors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Tumorigenesis |
| title | Epigenetic regulation of gastrointestinal cancers mediated by long non-coding RNAs |
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