Topical application of a cream containing nanoparticles with vitamin E for radiodermatitis prevention in women with breast cancer: A randomized, triple-blind, controlled pilot trial
Most topical agents for radiodermatitis prevention are not based on its pathophysiology, mainly caused by the indirect effects of radiation from reactive oxygen species release. Therefore, this study aimed to evaluate the effect of vitamin E-containing nanoparticle cream as an antioxidant for radiod...
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Veröffentlicht in: | European journal of oncology nursing : the official journal of European Oncology Nursing Society 2022-12, Vol.61, p.102230-102230, Article 102230 |
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container_title | European journal of oncology nursing : the official journal of European Oncology Nursing Society |
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creator | Queiroz Schmidt, Fernanda Mateus Serna González, Carol Viviana Mattar, Rodrigo Calixto Lopes, Luciana Biagini Santos, Marinilce Fagundes Santos, Vera Lúcia Conceição de Gouveia |
description | Most topical agents for radiodermatitis prevention are not based on its pathophysiology, mainly caused by the indirect effects of radiation from reactive oxygen species release. Therefore, this study aimed to evaluate the effect of vitamin E-containing nanoparticle cream as an antioxidant for radiodermatitis prevention.
A randomized, triple-blind, parallel pilot study conducted in an Oncology Hospital including 40 adult women with breast cancer, and healthy skin, submitted to radiotherapy, divided into three groups: Intervention (12; 30%) receiving cream with nanoparticles containing vitamin E; Control 1 (14; 35%) cream without nanoparticles or vitamin E; Control 2 (14; 35%) cream with nanoparticles without vitamin E. Incidence, grade and time to onset of radiodermatitis were primary outcomes; health-related quality of life, reported symptoms, and breast temperature were secondary outcomes.
All patients were followed until the end of the study. All had radiodermatitis. There were no significant differences between the study groups regarding radiodermatitis grade, health-related quality of life, and breast temperatures. A protective effect of vitamin E-containing nanoparticle cream was identified regarding the onset time of radiodermatitis in patients who did not receive a boosted radiation dose (p = .03) and the occurrence of mild inframammary erythema (p = .04). Itching was reported by 90% of the women. The definitive calculated sample is 108 volunteers. There were no identified side effects.
A potential protective effect of a cream containing vitamin E nanoparticles was observed. This pilot study presents initial evidence about the role of a nanoencapsulated antioxidant in preventing radiodermatitis.
No. RBR-784F3Y; UTN-U1111-1201-5923.
•Up to 100% of radiotherapy patients develop radiodermatitis.•There is a lack of defining evidence in radiodermatitis prevention.•Few topical therapies for radiodermatitis prevention address tissue oxidative stress.•Vitamin E can potentially combat oxidative stress damage in the skin.•This pilot trial shows a protective effect of a cream with vitamin E nanoparticles. |
doi_str_mv | 10.1016/j.ejon.2022.102230 |
format | Article |
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A randomized, triple-blind, parallel pilot study conducted in an Oncology Hospital including 40 adult women with breast cancer, and healthy skin, submitted to radiotherapy, divided into three groups: Intervention (12; 30%) receiving cream with nanoparticles containing vitamin E; Control 1 (14; 35%) cream without nanoparticles or vitamin E; Control 2 (14; 35%) cream with nanoparticles without vitamin E. Incidence, grade and time to onset of radiodermatitis were primary outcomes; health-related quality of life, reported symptoms, and breast temperature were secondary outcomes.
All patients were followed until the end of the study. All had radiodermatitis. There were no significant differences between the study groups regarding radiodermatitis grade, health-related quality of life, and breast temperatures. A protective effect of vitamin E-containing nanoparticle cream was identified regarding the onset time of radiodermatitis in patients who did not receive a boosted radiation dose (p = .03) and the occurrence of mild inframammary erythema (p = .04). Itching was reported by 90% of the women. The definitive calculated sample is 108 volunteers. There were no identified side effects.
A potential protective effect of a cream containing vitamin E nanoparticles was observed. This pilot study presents initial evidence about the role of a nanoencapsulated antioxidant in preventing radiodermatitis.
No. RBR-784F3Y; UTN-U1111-1201-5923.
•Up to 100% of radiotherapy patients develop radiodermatitis.•There is a lack of defining evidence in radiodermatitis prevention.•Few topical therapies for radiodermatitis prevention address tissue oxidative stress.•Vitamin E can potentially combat oxidative stress damage in the skin.•This pilot trial shows a protective effect of a cream with vitamin E nanoparticles.</description><identifier>ISSN: 1462-3889</identifier><identifier>EISSN: 1532-2122</identifier><identifier>DOI: 10.1016/j.ejon.2022.102230</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Antioxidants ; Breast neoplasms ; Enterostomal Therapy ; Free radicals ; Nanotechnology ; Nursing care ; Oncology nursing ; Prevention ; Radiodermatitis ; Radiotherapy ; Vitamin E</subject><ispartof>European journal of oncology nursing : the official journal of European Oncology Nursing Society, 2022-12, Vol.61, p.102230-102230, Article 102230</ispartof><rights>2022 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-e02837f1418d91a20ba4f0b605dd20ace00aad5bbc151b7527f217e70e25020c3</citedby><cites>FETCH-LOGICAL-c333t-e02837f1418d91a20ba4f0b605dd20ace00aad5bbc151b7527f217e70e25020c3</cites><orcidid>0000-0002-9850-3030</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejon.2022.102230$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Queiroz Schmidt, Fernanda Mateus</creatorcontrib><creatorcontrib>Serna González, Carol Viviana</creatorcontrib><creatorcontrib>Mattar, Rodrigo Calixto</creatorcontrib><creatorcontrib>Lopes, Luciana Biagini</creatorcontrib><creatorcontrib>Santos, Marinilce Fagundes</creatorcontrib><creatorcontrib>Santos, Vera Lúcia Conceição de Gouveia</creatorcontrib><title>Topical application of a cream containing nanoparticles with vitamin E for radiodermatitis prevention in women with breast cancer: A randomized, triple-blind, controlled pilot trial</title><title>European journal of oncology nursing : the official journal of European Oncology Nursing Society</title><description>Most topical agents for radiodermatitis prevention are not based on its pathophysiology, mainly caused by the indirect effects of radiation from reactive oxygen species release. Therefore, this study aimed to evaluate the effect of vitamin E-containing nanoparticle cream as an antioxidant for radiodermatitis prevention.
A randomized, triple-blind, parallel pilot study conducted in an Oncology Hospital including 40 adult women with breast cancer, and healthy skin, submitted to radiotherapy, divided into three groups: Intervention (12; 30%) receiving cream with nanoparticles containing vitamin E; Control 1 (14; 35%) cream without nanoparticles or vitamin E; Control 2 (14; 35%) cream with nanoparticles without vitamin E. Incidence, grade and time to onset of radiodermatitis were primary outcomes; health-related quality of life, reported symptoms, and breast temperature were secondary outcomes.
All patients were followed until the end of the study. All had radiodermatitis. There were no significant differences between the study groups regarding radiodermatitis grade, health-related quality of life, and breast temperatures. A protective effect of vitamin E-containing nanoparticle cream was identified regarding the onset time of radiodermatitis in patients who did not receive a boosted radiation dose (p = .03) and the occurrence of mild inframammary erythema (p = .04). Itching was reported by 90% of the women. The definitive calculated sample is 108 volunteers. There were no identified side effects.
A potential protective effect of a cream containing vitamin E nanoparticles was observed. This pilot study presents initial evidence about the role of a nanoencapsulated antioxidant in preventing radiodermatitis.
No. RBR-784F3Y; UTN-U1111-1201-5923.
•Up to 100% of radiotherapy patients develop radiodermatitis.•There is a lack of defining evidence in radiodermatitis prevention.•Few topical therapies for radiodermatitis prevention address tissue oxidative stress.•Vitamin E can potentially combat oxidative stress damage in the skin.•This pilot trial shows a protective effect of a cream with vitamin E nanoparticles.</description><subject>Antioxidants</subject><subject>Breast neoplasms</subject><subject>Enterostomal Therapy</subject><subject>Free radicals</subject><subject>Nanotechnology</subject><subject>Nursing care</subject><subject>Oncology nursing</subject><subject>Prevention</subject><subject>Radiodermatitis</subject><subject>Radiotherapy</subject><subject>Vitamin E</subject><issn>1462-3889</issn><issn>1532-2122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxiMEEqXwApx85EAWe7zZZBGXqip_pEpcytma2BOYlWMH292Kvhfvh0M4c5oZ-_t9I_trmtdK7pRUh3enHZ1i2IEEqAcAWj5pLlSnoQUF8LT2-wO0ehiOz5sXOZ-klEfdDxfN77u4sEUvcFl8bQrHIOIkUNhEOAsbQ0EOHL6LgCEumApbT1k8cPkhzlxw5iBuxBSTSOg4OkpzdSmcxZLoTOGvY9U8xJnCho3VOhdhMVhK78VVJYOLMz-SeytK4sVTO3oOdVr3p-g9ObGwj2W9Rv-yeTahz_TqX71svn28ubv-3N5-_fTl-uq2tVrr0pKEQfeT2qvBHRWCHHE_yfEgO-dAoiUpEV03jlZ1auw76CdQPfWSoJMgrb5s3my-S4o_7ykXM3O25D0GivfZQK-H_VGBPFQpbFKbYs6JJrMknjH9MkqaNSNzMmtGZs3IbBlV6MMGUX3EmSmZbJnqrzhOZItxkf-H_wFKK57B</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Queiroz Schmidt, Fernanda Mateus</creator><creator>Serna González, Carol Viviana</creator><creator>Mattar, Rodrigo Calixto</creator><creator>Lopes, Luciana Biagini</creator><creator>Santos, Marinilce Fagundes</creator><creator>Santos, Vera Lúcia Conceição de Gouveia</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9850-3030</orcidid></search><sort><creationdate>202212</creationdate><title>Topical application of a cream containing nanoparticles with vitamin E for radiodermatitis prevention in women with breast cancer: A randomized, triple-blind, controlled pilot trial</title><author>Queiroz Schmidt, Fernanda Mateus ; Serna González, Carol Viviana ; Mattar, Rodrigo Calixto ; Lopes, Luciana Biagini ; Santos, Marinilce Fagundes ; Santos, Vera Lúcia Conceição de Gouveia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-e02837f1418d91a20ba4f0b605dd20ace00aad5bbc151b7527f217e70e25020c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Breast neoplasms</topic><topic>Enterostomal Therapy</topic><topic>Free radicals</topic><topic>Nanotechnology</topic><topic>Nursing care</topic><topic>Oncology nursing</topic><topic>Prevention</topic><topic>Radiodermatitis</topic><topic>Radiotherapy</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Queiroz Schmidt, Fernanda Mateus</creatorcontrib><creatorcontrib>Serna González, Carol Viviana</creatorcontrib><creatorcontrib>Mattar, Rodrigo Calixto</creatorcontrib><creatorcontrib>Lopes, Luciana Biagini</creatorcontrib><creatorcontrib>Santos, Marinilce Fagundes</creatorcontrib><creatorcontrib>Santos, Vera Lúcia Conceição de Gouveia</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of oncology nursing : the official journal of European Oncology Nursing Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Queiroz Schmidt, Fernanda Mateus</au><au>Serna González, Carol Viviana</au><au>Mattar, Rodrigo Calixto</au><au>Lopes, Luciana Biagini</au><au>Santos, Marinilce Fagundes</au><au>Santos, Vera Lúcia Conceição de Gouveia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical application of a cream containing nanoparticles with vitamin E for radiodermatitis prevention in women with breast cancer: A randomized, triple-blind, controlled pilot trial</atitle><jtitle>European journal of oncology nursing : the official journal of European Oncology Nursing Society</jtitle><date>2022-12</date><risdate>2022</risdate><volume>61</volume><spage>102230</spage><epage>102230</epage><pages>102230-102230</pages><artnum>102230</artnum><issn>1462-3889</issn><eissn>1532-2122</eissn><abstract>Most topical agents for radiodermatitis prevention are not based on its pathophysiology, mainly caused by the indirect effects of radiation from reactive oxygen species release. Therefore, this study aimed to evaluate the effect of vitamin E-containing nanoparticle cream as an antioxidant for radiodermatitis prevention.
A randomized, triple-blind, parallel pilot study conducted in an Oncology Hospital including 40 adult women with breast cancer, and healthy skin, submitted to radiotherapy, divided into three groups: Intervention (12; 30%) receiving cream with nanoparticles containing vitamin E; Control 1 (14; 35%) cream without nanoparticles or vitamin E; Control 2 (14; 35%) cream with nanoparticles without vitamin E. Incidence, grade and time to onset of radiodermatitis were primary outcomes; health-related quality of life, reported symptoms, and breast temperature were secondary outcomes.
All patients were followed until the end of the study. All had radiodermatitis. There were no significant differences between the study groups regarding radiodermatitis grade, health-related quality of life, and breast temperatures. A protective effect of vitamin E-containing nanoparticle cream was identified regarding the onset time of radiodermatitis in patients who did not receive a boosted radiation dose (p = .03) and the occurrence of mild inframammary erythema (p = .04). Itching was reported by 90% of the women. The definitive calculated sample is 108 volunteers. There were no identified side effects.
A potential protective effect of a cream containing vitamin E nanoparticles was observed. This pilot study presents initial evidence about the role of a nanoencapsulated antioxidant in preventing radiodermatitis.
No. RBR-784F3Y; UTN-U1111-1201-5923.
•Up to 100% of radiotherapy patients develop radiodermatitis.•There is a lack of defining evidence in radiodermatitis prevention.•Few topical therapies for radiodermatitis prevention address tissue oxidative stress.•Vitamin E can potentially combat oxidative stress damage in the skin.•This pilot trial shows a protective effect of a cream with vitamin E nanoparticles.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.ejon.2022.102230</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9850-3030</orcidid></addata></record> |
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subjects | Antioxidants Breast neoplasms Enterostomal Therapy Free radicals Nanotechnology Nursing care Oncology nursing Prevention Radiodermatitis Radiotherapy Vitamin E |
title | Topical application of a cream containing nanoparticles with vitamin E for radiodermatitis prevention in women with breast cancer: A randomized, triple-blind, controlled pilot trial |
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