MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing

Ribosome biogenesis proceeds with the successive cleavage and trimming of the large 47S rRNA precursor, where the RNA exosome plays major roles in concert with the Ski2-like RNA helicase, MTR4. The recent finding of a consensus amino acid sequence, the arch-interacting motif (AIM), for binding to th...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-12, Vol.637, p.203-209
Hauptverfasser:	Miyao, Sotaro, Saito, Kanako, Oshima, Renta, Kawahara, Kohichi, Nagahama, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Exosome Multienzyme Ribonuclease Complex - genetics Humans MTR4 Nuclear Proteins Nucleolar stress Oligonucleotides PICT1 Pre-rRNA processing Ribosome biogenesis RNA exosome RNA Helicases - genetics RNA Precursors - genetics RNA Processing, Post-Transcriptional RNA, Ribosomal, 5.8S RNA, Small Interfering Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Tumor Suppressor Proteins - genetics
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