An Electrophysiological Technique to Accurately Diagnose and Treat Erectile Dysfunction
Erectile dysfunction (ED) is a common disease in males. In the past, the first-line treatment of ED was mainly noninvasive-psychotherapy and oral phosphodiesterase 5 (PDE5) inhibitors. Oral PDE5 inhibitors often need to be used before sexual intercourse and do not repair the pathological damage; hen...
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Veröffentlicht in: | Journal of visualized experiments 2022-11 (189) |
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creator | Liu, Kaifeng Wang, Zihao Liu, Yu Zhu, Panyan Zhang, Shengmin Lu, Shuai Hu, Wentao Xu, Bing Zhang, Shao Gong, Yongzhan |
description | Erectile dysfunction (ED) is a common disease in males. In the past, the first-line treatment of ED was mainly noninvasive-psychotherapy and oral phosphodiesterase 5 (PDE5) inhibitors. Oral PDE5 inhibitors often need to be used before sexual intercourse and do not repair the pathological damage; hence, the therapeutic effect for secondary ED caused by neurological or endocrine disorders is poor. Second-line treatments mainly include penile corpus cavernosum injection of alprostadil, transurethral administration, vacuum negative pressure devices, and other methods, with obvious side effects such as local pain. The third-line treatment mainly refers to penile prosthesis implantation. Indications of this treatment are strict, complications such as mechanical failure and infection may occur after operation, and it is expensive. Other treatments such as stem cell therapy and gene therapy are still in the experimental research stage and have not been used in clinics. A new treatment based on an electrophysiological technique combines a medical infrared thermal imager with low-frequency (20-50 Hz) neuromuscular electrical stimulation, which has achieved good results in the prevention and treatment of female pelvic floor dysfunction. Male generative organs are located in the pelvic floor area, and their normal function not only depends on the integrity of the structure and function of the male generative organs, but is also closely related to the blood vessels, nerves, muscles, and other pelvic floor organs. Therefore, this electrophysiological technique was applied to male ED, focusing on the observation of the penis, groin, and hypogastrium for accurate diagnosis and treatment. This demonstrated effective improvement in the conscious erectile status and erectile function scores of patients suffering from ED. |
doi_str_mv | 10.3791/63851 |
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In the past, the first-line treatment of ED was mainly noninvasive-psychotherapy and oral phosphodiesterase 5 (PDE5) inhibitors. Oral PDE5 inhibitors often need to be used before sexual intercourse and do not repair the pathological damage; hence, the therapeutic effect for secondary ED caused by neurological or endocrine disorders is poor. Second-line treatments mainly include penile corpus cavernosum injection of alprostadil, transurethral administration, vacuum negative pressure devices, and other methods, with obvious side effects such as local pain. The third-line treatment mainly refers to penile prosthesis implantation. Indications of this treatment are strict, complications such as mechanical failure and infection may occur after operation, and it is expensive. Other treatments such as stem cell therapy and gene therapy are still in the experimental research stage and have not been used in clinics. A new treatment based on an electrophysiological technique combines a medical infrared thermal imager with low-frequency (20-50 Hz) neuromuscular electrical stimulation, which has achieved good results in the prevention and treatment of female pelvic floor dysfunction. Male generative organs are located in the pelvic floor area, and their normal function not only depends on the integrity of the structure and function of the male generative organs, but is also closely related to the blood vessels, nerves, muscles, and other pelvic floor organs. Therefore, this electrophysiological technique was applied to male ED, focusing on the observation of the penis, groin, and hypogastrium for accurate diagnosis and treatment. This demonstrated effective improvement in the conscious erectile status and erectile function scores of patients suffering from ED.</description><identifier>ISSN: 1940-087X</identifier><identifier>EISSN: 1940-087X</identifier><identifier>DOI: 10.3791/63851</identifier><identifier>PMID: 36408982</identifier><language>eng</language><publisher>United States</publisher><subject>Electric Stimulation Therapy ; Erectile Dysfunction - diagnosis ; Erectile Dysfunction - therapy ; Female ; Humans ; Male ; Penis ; Phosphodiesterase 5 Inhibitors - therapeutic use ; Prostatectomy - adverse effects</subject><ispartof>Journal of visualized experiments, 2022-11 (189)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3843,27924,27925</link.rule.ids><linktorsrc>$$Uhttp://dx.doi.org/10.3791/63851$$EView_record_in_Journal_of_Visualized_Experiments$$FView_record_in_$$GJournal_of_Visualized_Experiments</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36408982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Kaifeng</creatorcontrib><creatorcontrib>Wang, Zihao</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Zhu, Panyan</creatorcontrib><creatorcontrib>Zhang, Shengmin</creatorcontrib><creatorcontrib>Lu, Shuai</creatorcontrib><creatorcontrib>Hu, Wentao</creatorcontrib><creatorcontrib>Xu, Bing</creatorcontrib><creatorcontrib>Zhang, Shao</creatorcontrib><creatorcontrib>Gong, Yongzhan</creatorcontrib><title>An Electrophysiological Technique to Accurately Diagnose and Treat Erectile Dysfunction</title><title>Journal of visualized experiments</title><addtitle>J Vis Exp</addtitle><description>Erectile dysfunction (ED) is a common disease in males. In the past, the first-line treatment of ED was mainly noninvasive-psychotherapy and oral phosphodiesterase 5 (PDE5) inhibitors. Oral PDE5 inhibitors often need to be used before sexual intercourse and do not repair the pathological damage; hence, the therapeutic effect for secondary ED caused by neurological or endocrine disorders is poor. Second-line treatments mainly include penile corpus cavernosum injection of alprostadil, transurethral administration, vacuum negative pressure devices, and other methods, with obvious side effects such as local pain. The third-line treatment mainly refers to penile prosthesis implantation. Indications of this treatment are strict, complications such as mechanical failure and infection may occur after operation, and it is expensive. Other treatments such as stem cell therapy and gene therapy are still in the experimental research stage and have not been used in clinics. A new treatment based on an electrophysiological technique combines a medical infrared thermal imager with low-frequency (20-50 Hz) neuromuscular electrical stimulation, which has achieved good results in the prevention and treatment of female pelvic floor dysfunction. Male generative organs are located in the pelvic floor area, and their normal function not only depends on the integrity of the structure and function of the male generative organs, but is also closely related to the blood vessels, nerves, muscles, and other pelvic floor organs. Therefore, this electrophysiological technique was applied to male ED, focusing on the observation of the penis, groin, and hypogastrium for accurate diagnosis and treatment. This demonstrated effective improvement in the conscious erectile status and erectile function scores of patients suffering from ED.</description><subject>Electric Stimulation Therapy</subject><subject>Erectile Dysfunction - diagnosis</subject><subject>Erectile Dysfunction - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Penis</subject><subject>Phosphodiesterase 5 Inhibitors - therapeutic use</subject><subject>Prostatectomy - adverse effects</subject><issn>1940-087X</issn><issn>1940-087X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAUhS0EoqX0LyAvSCwBv-OMVVseUiWWItgix7lpg9y42MmQf99AC2K6Z_jO0dWH0JSSe55m9EFxLekZGtNMkITo9OP8Xx6hqxg_CVGMSH2JRlwJojPNxuh91uClA9sGv9_2sfbOb2prHF6D3Tb1Vwe49XhmbRdMC67Hi9psGh8Bm6bE6wCmxcsw9GsHeNHHqmuG7JtrdFEZF2F6uhP09rhcz5-T1evTy3y2SixLWZuIQleWyopBwaQAoSqwGUhKmCkZUZJIkJIrLgGUUAqsKdKy1EZYQy0zkk_Q3XF3H_zwbGzzXR0tOGca8F3MWcq1yAjJ6IDeHlEbfIwBqnwf6p0JfU5J_u0w_3E4cDenya7YQflH_UrjB8eMbDE</recordid><startdate>20221104</startdate><enddate>20221104</enddate><creator>Liu, Kaifeng</creator><creator>Wang, Zihao</creator><creator>Liu, Yu</creator><creator>Zhu, Panyan</creator><creator>Zhang, Shengmin</creator><creator>Lu, Shuai</creator><creator>Hu, Wentao</creator><creator>Xu, Bing</creator><creator>Zhang, Shao</creator><creator>Gong, Yongzhan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20221104</creationdate><title>An Electrophysiological Technique to Accurately Diagnose and Treat Erectile Dysfunction</title><author>Liu, Kaifeng ; Wang, Zihao ; Liu, Yu ; Zhu, Panyan ; Zhang, Shengmin ; Lu, Shuai ; Hu, Wentao ; Xu, Bing ; Zhang, Shao ; Gong, Yongzhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-4b8fc15f2eb254e46fec9e5102ad206505e553635ee6466ecab7dd8a4ca1c2a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Electric Stimulation Therapy</topic><topic>Erectile Dysfunction - diagnosis</topic><topic>Erectile Dysfunction - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Penis</topic><topic>Phosphodiesterase 5 Inhibitors - therapeutic use</topic><topic>Prostatectomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Kaifeng</creatorcontrib><creatorcontrib>Wang, Zihao</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Zhu, Panyan</creatorcontrib><creatorcontrib>Zhang, Shengmin</creatorcontrib><creatorcontrib>Lu, Shuai</creatorcontrib><creatorcontrib>Hu, Wentao</creatorcontrib><creatorcontrib>Xu, Bing</creatorcontrib><creatorcontrib>Zhang, Shao</creatorcontrib><creatorcontrib>Gong, Yongzhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of visualized experiments</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Kaifeng</au><au>Wang, Zihao</au><au>Liu, Yu</au><au>Zhu, Panyan</au><au>Zhang, Shengmin</au><au>Lu, Shuai</au><au>Hu, Wentao</au><au>Xu, Bing</au><au>Zhang, Shao</au><au>Gong, Yongzhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Electrophysiological Technique to Accurately Diagnose and Treat Erectile Dysfunction</atitle><jtitle>Journal of visualized experiments</jtitle><addtitle>J Vis Exp</addtitle><date>2022-11-04</date><risdate>2022</risdate><issue>189</issue><issn>1940-087X</issn><eissn>1940-087X</eissn><abstract>Erectile dysfunction (ED) is a common disease in males. In the past, the first-line treatment of ED was mainly noninvasive-psychotherapy and oral phosphodiesterase 5 (PDE5) inhibitors. Oral PDE5 inhibitors often need to be used before sexual intercourse and do not repair the pathological damage; hence, the therapeutic effect for secondary ED caused by neurological or endocrine disorders is poor. Second-line treatments mainly include penile corpus cavernosum injection of alprostadil, transurethral administration, vacuum negative pressure devices, and other methods, with obvious side effects such as local pain. The third-line treatment mainly refers to penile prosthesis implantation. Indications of this treatment are strict, complications such as mechanical failure and infection may occur after operation, and it is expensive. Other treatments such as stem cell therapy and gene therapy are still in the experimental research stage and have not been used in clinics. A new treatment based on an electrophysiological technique combines a medical infrared thermal imager with low-frequency (20-50 Hz) neuromuscular electrical stimulation, which has achieved good results in the prevention and treatment of female pelvic floor dysfunction. Male generative organs are located in the pelvic floor area, and their normal function not only depends on the integrity of the structure and function of the male generative organs, but is also closely related to the blood vessels, nerves, muscles, and other pelvic floor organs. Therefore, this electrophysiological technique was applied to male ED, focusing on the observation of the penis, groin, and hypogastrium for accurate diagnosis and treatment. This demonstrated effective improvement in the conscious erectile status and erectile function scores of patients suffering from ED.</abstract><cop>United States</cop><pmid>36408982</pmid><doi>10.3791/63851</doi><oa>free_for_read</oa></addata></record> |
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subjects | Electric Stimulation Therapy Erectile Dysfunction - diagnosis Erectile Dysfunction - therapy Female Humans Male Penis Phosphodiesterase 5 Inhibitors - therapeutic use Prostatectomy - adverse effects |
title | An Electrophysiological Technique to Accurately Diagnose and Treat Erectile Dysfunction |
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