NIR‐II Responsive Upconversion Nanoprobe with Simultaneously Enhanced Single‐Band Red Luminescence and Phase/Size Control for Bioimaging and Photodynamic Therapy

Lanthanide based upconversion (UC) nanoprobes have emerged as promising agents for biological applications. Extending the excitation light to the second near‐infrared (NIR‐II), instead of the traditional 980/808 nm light, and realizing NIR‐II responsive single‐band red UC emission is highly demanded...

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Veröffentlicht in:Advanced materials (Weinheim) 2023-02, Vol.35 (7), p.e2207038-n/a
Hauptverfasser: Bi, Shenghui, Deng, Zhiming, Huang, Junqing, Wen, Xingwang, Zeng, Songjun
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Sprache:eng
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Zusammenfassung:Lanthanide based upconversion (UC) nanoprobes have emerged as promising agents for biological applications. Extending the excitation light to the second near‐infrared (NIR‐II), instead of the traditional 980/808 nm light, and realizing NIR‐II responsive single‐band red UC emission is highly demanded for bioimaging application, which has not yet been explored. Here, a new type of NIR‐II (1532 nm) light responsive UC nanoparticles (UCNPs) with enhanced single‐band red UC emission and controllable phase and size is designed by introducing Er3+ as sensitizer and utilizing Mn2+ as energy manipulator. Through tuning the content of Mn2+ in NaLnF4:Er/Mn, the crystal phase, size, and emitting color are readily controlled, and the red‐to‐green (R/G) ratio is significantly increased from ≈20 to ≈300, leading to NIR‐II responsive single band red emission via efficient energy transfer between Er3+ and Mn2+. In addition, the single band red emitting intensity can be further improved by coating shell to avoid the surface quenching effect. More importantly, NIR‐II light activated red UC bioimaging and photodynamic therapy through loading photosensitizer of zinc phthalocyanine are successfully achieved for the first time. These findings provide a new strategy of designing NIR‐II light responsive single‐band red emissive UCNPs for biomedical applications. A new type of second near‐infrared (NIR‐II) (1532 nm) light responsive upconversion nanoparticles with enhanced single‐band red upconversion emission and controllable phase and size is designed by introducing Er3+ as sensitizer and utilizing Mn2+ as energy manipulator. Moreover, NIR‐II light activated red upconversion bioimaging and photodynamic therapy are successfully achieved for the first time.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202207038