Blood levels of MCP‐1 modulate the genetic risks of Alzheimer's disease mediated by HLA‐DRB1 and APOE for Alzheimer's disease

Introduction C‐Reactive protein (CRP) and monocyte chemoattractant protein‐1 (MCP‐1) are both implicated in the peripheral proinflammatory cascade and blood‒brain barrier (BBB) disruption. Since the blood CRP level increases Alzheimer's disease (AD) risk depending on the apolipoprotein E (APOE)...

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Veröffentlicht in:	Alzheimer's & dementia 2023-05, Vol.19 (5), p.1925-1937
Hauptverfasser:	Huang, Jinghan, Stein, Thor D., Wang, Yixuan, Ang, Ting Fang Alvin, Tao, Qiushan, Lunetta, Kathryn L., Massaro, Joseph, Akhter‐Khan, Samia C., Mez, Jesse, Au, Rhoda, Farrer, Lindsay A., Zhang, Xiaoling, Qiu, Wei Qiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - blood Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 - genetics Apolipoproteins E - genetics blood Chemokine CCL2 - blood Genotype genotypes HLA-DRB1 Chains - genetics Humans MCP‐1
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