Intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an Alzheimer's disease model

•APP overexpression in the hippocampus induced anxiety-like behaviors in rats.•APP overexpression in the hippocampus induced depressive-like behaviors in rats.•Psychiatric symptoms were accompanied with changes in expression of M1/M2 markers.•IFNβ improved anxious/depressive-like behaviors in AD rat...

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Veröffentlicht in:	Neuroscience letters 2023-01, Vol.792, p.136968-136968, Article 136968
Hauptverfasser:	Farhangian, Mohsen, Azarafrouz, Forouzan, Chavoshinezhad, Sara, Dargahi, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer’s disease Animals Anxiety Anxiety - drug therapy Depression Depression - drug therapy Humans Immunologic Factors - therapeutic use Interferon-beta Microglia Microglia - metabolism Polarization Quality of Life Rats
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