Identification of potent and selective inhibitors of PKR via virtual screening and traditional design

Protein Kinase RNA-activated (PKR) inhibition is thought to be relevant for immunology due to the potential to reduce macrophage and dendritic cell responses to bacteria and its signaling downstream of TNFα. PKR is also associated with neuroscience indications such as Alzheimer's disease due to...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2023-01, Vol.79, p.129047-129047, Article 129047
Hauptverfasser:	Cusack, K P, Argiriadi, M A, Gordon, T D, Harris, C M, Herold, J M, Hoemann, M Z, Yestrepsky, B D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Drug Discovery - methods Humans Macrophages - drug effects Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology
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