Synthesis of α‑(Trifluoromethyl)styrenes and 1,3-Di(trifluoromethyl)indanes via Electrophilic Activation of TMS Ethers of (Trifluoromethyl)benzyl Alcohols in Brønsted Acids

TMS ethers of CF3-benzyl alcohols (and their heterocyclic analogues) undergo elimination of TMSOH molecule with the formation of α-(trifluoromethyl)­styrenes in yields of up to 90% under the action of strong Brønsted acids TfOH or H2SO4. Under the acidic conditions upon prolongation of the reaction,...

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Veröffentlicht in:	Journal of organic chemistry 2022-12, Vol.87 (23), p.15845-15862
Hauptverfasser:	Khoroshilova, Olesya V., Boyarskaya, Irina A., Vasilyev, Aleksander V.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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