Human leukocyte antigen system associations in Malassezia-related skin diseases

Background The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations betwe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of dermatological research 2023-05, Vol.315 (4), p.895-902
Hauptverfasser:	Lindsø Andersen, P., Jemec, G. B., Erikstrup, C., Didriksen, M., Dinh, K. M., Mikkelsen, S., Sørensen, E., Nielsen, K. R., Bruun, M. T., Hjalgrim, H., Hansen, T. F., Sækmose, S. G., Ostrowski, S. R., Saunte, D. M. L., Pedersen, O. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Antifungal agents Antigen presentation Antigens Blood Donors Case-Control Studies Cohort Studies Denmark Dermatology Dermatomycoses - blood Dermatomycoses - genetics Drb1 protein Female Genotype Genotypes Genotyping Histocompatibility antigen HLA HLA Antigens - genetics Humans Ketoconazole Leukocytes Malassezia Malassezia - genetics Male Medicine Medicine & Public Health Middle Aged Original Paper Skin diseases Skin Diseases, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	902
container_issue	4
container_start_page	895
container_title	Archives of dermatological research
container_volume	315
creator	Lindsø Andersen, P. Jemec, G. B. Erikstrup, C. Didriksen, M. Dinh, K. M. Mikkelsen, S. Sørensen, E. Nielsen, K. R. Bruun, M. T. Hjalgrim, H. Hansen, T. F. Sækmose, S. G. Ostrowski, S. R. Saunte, D. M. L. Pedersen, O. B.
description	Background The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia- related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B57:01, OR 1.19 (95% CI: 1.09–1.31), C01:02, OR 1.19 (95% CI: 1.08–1.32), C06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB101:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB102:01, OR 0.89 (95% CI: 0.85–0.94), and DRB103:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.
doi_str_mv	10.1007/s00403-022-02454-9
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2737471262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2737471262</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5e5f39f36bebaab033de90e1f256267d018e49921ae3293c2583c934cbe969563</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwBxhQJBaWgO1znHpECChSUReQ2CwnuVRp81FyyVB-PYaUDzEwWOe7e97X1svYqeCXgvP4ijhXHEIupT8qUqHZY2OhwLfavOz_uo_YEdGKe1E8FYdsBBqM0hCN2WLWV64OSuzXTbrtMHB1VyyxDmhLHVaBI2rSwnVFU1NQ1MGjK_0I3woXtli6DrOA1n6eFYSOkI7ZQe5KwpNdnbDnu9unm1k4X9w_3FzPwxTiqAsjjHIwOegEE-cSDpCh4ShyGWmp44yLKSpjpHAI0kAqoymkBlSaoNEm0jBhF4Pvpm1ee6TOVgWlWJauxqYnK2OIVSyklh49_4Oumr6t_e88ZYzgsVHCU3Kg0rYhajG3m7aoXLu1gtuPuO0Qt_Vx28-4rfGis511n1SYfUu-8vUADAD5Vb3E9uftf2zfAaZVinc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2799107941</pqid></control><display><type>article</type><title>Human leukocyte antigen system associations in Malassezia-related skin diseases</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Lindsø Andersen, P. ; Jemec, G. B. ; Erikstrup, C. ; Didriksen, M. ; Dinh, K. M. ; Mikkelsen, S. ; Sørensen, E. ; Nielsen, K. R. ; Bruun, M. T. ; Hjalgrim, H. ; Hansen, T. F. ; Sækmose, S. G. ; Ostrowski, S. R. ; Saunte, D. M. L. ; Pedersen, O. B.</creator><creatorcontrib>Lindsø Andersen, P. ; Jemec, G. B. ; Erikstrup, C. ; Didriksen, M. ; Dinh, K. M. ; Mikkelsen, S. ; Sørensen, E. ; Nielsen, K. R. ; Bruun, M. T. ; Hjalgrim, H. ; Hansen, T. F. ; Sækmose, S. G. ; Ostrowski, S. R. ; Saunte, D. M. L. ; Pedersen, O. B. ; DBDS Genetic Consortium</creatorcontrib><description>Background The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia- related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B57:01, OR 1.19 (95% CI: 1.09–1.31), C01:02, OR 1.19 (95% CI: 1.08–1.32), C06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB101:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB102:01, OR 0.89 (95% CI: 0.85–0.94), and DRB103:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.</description><identifier>ISSN: 1432-069X</identifier><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-022-02454-9</identifier><identifier>PMID: 36394635</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Alleles ; Antifungal agents ; Antigen presentation ; Antigens ; Blood Donors ; Case-Control Studies ; Cohort Studies ; Denmark ; Dermatology ; Dermatomycoses - blood ; Dermatomycoses - genetics ; Drb1 protein ; Female ; Genotype ; Genotypes ; Genotyping ; Histocompatibility antigen HLA ; HLA Antigens - genetics ; Humans ; Ketoconazole ; Leukocytes ; Malassezia ; Malassezia - genetics ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Paper ; Skin diseases ; Skin Diseases, Genetic</subject><ispartof>Archives of dermatological research, 2023-05, Vol.315 (4), p.895-902</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5e5f39f36bebaab033de90e1f256267d018e49921ae3293c2583c934cbe969563</citedby><cites>FETCH-LOGICAL-c375t-5e5f39f36bebaab033de90e1f256267d018e49921ae3293c2583c934cbe969563</cites><orcidid>0000-0003-1881-5673 ; 0000-0002-4856-496X ; 0000-0001-7806-1143 ; 0000-0002-8819-5388 ; 0000-0002-4436-6798 ; 0000-0002-0132-4715 ; 0000-0002-0712-2540 ; 0000-0001-6703-7762 ; 0000-0001-7953-1047 ; 0000-0001-6551-6647 ; 0000-0003-2312-5976 ; 0000-0002-1346-0052 ; 0000-0001-5288-3851</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-022-02454-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-022-02454-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36394635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindsø Andersen, P.</creatorcontrib><creatorcontrib>Jemec, G. B.</creatorcontrib><creatorcontrib>Erikstrup, C.</creatorcontrib><creatorcontrib>Didriksen, M.</creatorcontrib><creatorcontrib>Dinh, K. M.</creatorcontrib><creatorcontrib>Mikkelsen, S.</creatorcontrib><creatorcontrib>Sørensen, E.</creatorcontrib><creatorcontrib>Nielsen, K. R.</creatorcontrib><creatorcontrib>Bruun, M. T.</creatorcontrib><creatorcontrib>Hjalgrim, H.</creatorcontrib><creatorcontrib>Hansen, T. F.</creatorcontrib><creatorcontrib>Sækmose, S. G.</creatorcontrib><creatorcontrib>Ostrowski, S. R.</creatorcontrib><creatorcontrib>Saunte, D. M. L.</creatorcontrib><creatorcontrib>Pedersen, O. B.</creatorcontrib><creatorcontrib>DBDS Genetic Consortium</creatorcontrib><title>Human leukocyte antigen system associations in Malassezia-related skin diseases</title><title>Archives of dermatological research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Background The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia- related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B57:01, OR 1.19 (95% CI: 1.09–1.31), C01:02, OR 1.19 (95% CI: 1.08–1.32), C06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB101:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB102:01, OR 0.89 (95% CI: 0.85–0.94), and DRB103:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.</description><subject>Adult</subject><subject>Alleles</subject><subject>Antifungal agents</subject><subject>Antigen presentation</subject><subject>Antigens</subject><subject>Blood Donors</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Denmark</subject><subject>Dermatology</subject><subject>Dermatomycoses - blood</subject><subject>Dermatomycoses - genetics</subject><subject>Drb1 protein</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Ketoconazole</subject><subject>Leukocytes</subject><subject>Malassezia</subject><subject>Malassezia - genetics</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Skin diseases</subject><subject>Skin Diseases, Genetic</subject><issn>1432-069X</issn><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQJBaWgO1znHpECChSUReQ2CwnuVRp81FyyVB-PYaUDzEwWOe7e97X1svYqeCXgvP4ijhXHEIupT8qUqHZY2OhwLfavOz_uo_YEdGKe1E8FYdsBBqM0hCN2WLWV64OSuzXTbrtMHB1VyyxDmhLHVaBI2rSwnVFU1NQ1MGjK_0I3woXtli6DrOA1n6eFYSOkI7ZQe5KwpNdnbDnu9unm1k4X9w_3FzPwxTiqAsjjHIwOegEE-cSDpCh4ShyGWmp44yLKSpjpHAI0kAqoymkBlSaoNEm0jBhF4Pvpm1ee6TOVgWlWJauxqYnK2OIVSyklh49_4Oumr6t_e88ZYzgsVHCU3Kg0rYhajG3m7aoXLu1gtuPuO0Qt_Vx28-4rfGis511n1SYfUu-8vUADAD5Vb3E9uftf2zfAaZVinc</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Lindsø Andersen, P.</creator><creator>Jemec, G. B.</creator><creator>Erikstrup, C.</creator><creator>Didriksen, M.</creator><creator>Dinh, K. M.</creator><creator>Mikkelsen, S.</creator><creator>Sørensen, E.</creator><creator>Nielsen, K. R.</creator><creator>Bruun, M. T.</creator><creator>Hjalgrim, H.</creator><creator>Hansen, T. F.</creator><creator>Sækmose, S. G.</creator><creator>Ostrowski, S. R.</creator><creator>Saunte, D. M. L.</creator><creator>Pedersen, O. B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1881-5673</orcidid><orcidid>https://orcid.org/0000-0002-4856-496X</orcidid><orcidid>https://orcid.org/0000-0001-7806-1143</orcidid><orcidid>https://orcid.org/0000-0002-8819-5388</orcidid><orcidid>https://orcid.org/0000-0002-4436-6798</orcidid><orcidid>https://orcid.org/0000-0002-0132-4715</orcidid><orcidid>https://orcid.org/0000-0002-0712-2540</orcidid><orcidid>https://orcid.org/0000-0001-6703-7762</orcidid><orcidid>https://orcid.org/0000-0001-7953-1047</orcidid><orcidid>https://orcid.org/0000-0001-6551-6647</orcidid><orcidid>https://orcid.org/0000-0003-2312-5976</orcidid><orcidid>https://orcid.org/0000-0002-1346-0052</orcidid><orcidid>https://orcid.org/0000-0001-5288-3851</orcidid></search><sort><creationdate>20230501</creationdate><title>Human leukocyte antigen system associations in Malassezia-related skin diseases</title><author>Lindsø Andersen, P. ; Jemec, G. B. ; Erikstrup, C. ; Didriksen, M. ; Dinh, K. M. ; Mikkelsen, S. ; Sørensen, E. ; Nielsen, K. R. ; Bruun, M. T. ; Hjalgrim, H. ; Hansen, T. F. ; Sækmose, S. G. ; Ostrowski, S. R. ; Saunte, D. M. L. ; Pedersen, O. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5e5f39f36bebaab033de90e1f256267d018e49921ae3293c2583c934cbe969563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Antifungal agents</topic><topic>Antigen presentation</topic><topic>Antigens</topic><topic>Blood Donors</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Denmark</topic><topic>Dermatology</topic><topic>Dermatomycoses - blood</topic><topic>Dermatomycoses - genetics</topic><topic>Drb1 protein</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA Antigens - genetics</topic><topic>Humans</topic><topic>Ketoconazole</topic><topic>Leukocytes</topic><topic>Malassezia</topic><topic>Malassezia - genetics</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Skin diseases</topic><topic>Skin Diseases, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindsø Andersen, P.</creatorcontrib><creatorcontrib>Jemec, G. B.</creatorcontrib><creatorcontrib>Erikstrup, C.</creatorcontrib><creatorcontrib>Didriksen, M.</creatorcontrib><creatorcontrib>Dinh, K. M.</creatorcontrib><creatorcontrib>Mikkelsen, S.</creatorcontrib><creatorcontrib>Sørensen, E.</creatorcontrib><creatorcontrib>Nielsen, K. R.</creatorcontrib><creatorcontrib>Bruun, M. T.</creatorcontrib><creatorcontrib>Hjalgrim, H.</creatorcontrib><creatorcontrib>Hansen, T. F.</creatorcontrib><creatorcontrib>Sækmose, S. G.</creatorcontrib><creatorcontrib>Ostrowski, S. R.</creatorcontrib><creatorcontrib>Saunte, D. M. L.</creatorcontrib><creatorcontrib>Pedersen, O. B.</creatorcontrib><creatorcontrib>DBDS Genetic Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindsø Andersen, P.</au><au>Jemec, G. B.</au><au>Erikstrup, C.</au><au>Didriksen, M.</au><au>Dinh, K. M.</au><au>Mikkelsen, S.</au><au>Sørensen, E.</au><au>Nielsen, K. R.</au><au>Bruun, M. T.</au><au>Hjalgrim, H.</au><au>Hansen, T. F.</au><au>Sækmose, S. G.</au><au>Ostrowski, S. R.</au><au>Saunte, D. M. L.</au><au>Pedersen, O. B.</au><aucorp>DBDS Genetic Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human leukocyte antigen system associations in Malassezia-related skin diseases</atitle><jtitle>Archives of dermatological research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>315</volume><issue>4</issue><spage>895</spage><epage>902</epage><pages>895-902</pages><issn>1432-069X</issn><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Background The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia- related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B57:01, OR 1.19 (95% CI: 1.09–1.31), C01:02, OR 1.19 (95% CI: 1.08–1.32), C06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB101:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB102:01, OR 0.89 (95% CI: 0.85–0.94), and DRB103:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36394635</pmid><doi>10.1007/s00403-022-02454-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1881-5673</orcidid><orcidid>https://orcid.org/0000-0002-4856-496X</orcidid><orcidid>https://orcid.org/0000-0001-7806-1143</orcidid><orcidid>https://orcid.org/0000-0002-8819-5388</orcidid><orcidid>https://orcid.org/0000-0002-4436-6798</orcidid><orcidid>https://orcid.org/0000-0002-0132-4715</orcidid><orcidid>https://orcid.org/0000-0002-0712-2540</orcidid><orcidid>https://orcid.org/0000-0001-6703-7762</orcidid><orcidid>https://orcid.org/0000-0001-7953-1047</orcidid><orcidid>https://orcid.org/0000-0001-6551-6647</orcidid><orcidid>https://orcid.org/0000-0003-2312-5976</orcidid><orcidid>https://orcid.org/0000-0002-1346-0052</orcidid><orcidid>https://orcid.org/0000-0001-5288-3851</orcidid></addata></record>
fulltext	fulltext
identifier	ISSN: 1432-069X
ispartof	Archives of dermatological research, 2023-05, Vol.315 (4), p.895-902
issn	1432-069X 0340-3696 1432-069X
language	eng
recordid	cdi_proquest_miscellaneous_2737471262
source	MEDLINE; Springer Nature - Complete Springer Journals
subjects	Adult Alleles Antifungal agents Antigen presentation Antigens Blood Donors Case-Control Studies Cohort Studies Denmark Dermatology Dermatomycoses - blood Dermatomycoses - genetics Drb1 protein Female Genotype Genotypes Genotyping Histocompatibility antigen HLA HLA Antigens - genetics Humans Ketoconazole Leukocytes Malassezia Malassezia - genetics Male Medicine Medicine & Public Health Middle Aged Original Paper Skin diseases Skin Diseases, Genetic
title	Human leukocyte antigen system associations in Malassezia-related skin diseases
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A38%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20leukocyte%20antigen%20system%20associations%20in%20Malassezia-related%20skin%20diseases&rft.jtitle=Archives%20of%20dermatological%20research&rft.au=Linds%C3%B8%20Andersen,%20P.&rft.aucorp=DBDS%20Genetic%20Consortium&rft.date=2023-05-01&rft.volume=315&rft.issue=4&rft.spage=895&rft.epage=902&rft.pages=895-902&rft.issn=1432-069X&rft.eissn=1432-069X&rft_id=info:doi/10.1007/s00403-022-02454-9&rft_dat=%3Cproquest_cross%3E2737471262%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2799107941&rft_id=info:pmid/36394635&rfr_iscdi=true