Immunoglobulin G4-related disease in the sigmoid colon in patient with severe colonic fibrosis and obstruction: A case report

Immunoglobulin G4-related disease in the sigmoid colon in patient with severe colonic fibrosis and obstruction: A case report

BACKGROUNDImmunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition characterized by abundant IgG4 positive plasma cells and fibrosis in the affected tissues. It affects most parts of the body; however, there are not many reports on IgG4-RD involving the colon. CASE SUMMARYA 50-yea...

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Veröffentlicht in:World journal of gastrointestinal surgery 2022, Vol.14 (10), p.1169-1178
Hauptverfasser: Zhan, Wen-Li, Liu, Liang, Jiang, Wei, He, Fang-Xun, Qu, Hai-Tao, Cao, Zhi-Xin, Xu, Xiang-Shang
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container_end_page 1178
container_issue 10
container_start_page 1169
container_title World journal of gastrointestinal surgery
container_volume 14
creator Zhan, Wen-Li
Liu, Liang
Jiang, Wei
He, Fang-Xun
Qu, Hai-Tao
Cao, Zhi-Xin
Xu, Xiang-Shang
description BACKGROUNDImmunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition characterized by abundant IgG4 positive plasma cells and fibrosis in the affected tissues. It affects most parts of the body; however, there are not many reports on IgG4-RD involving the colon. CASE SUMMARYA 50-year-old man complaining of intermittent fever for more than two years was referred to our hospital. Based on various investigations before surgery, we diagnosed him with chronic perforation of the sigmoid colon caused by inflammatory change or tumor. IgG blood tests before the operation suggested IgG4-RD, and postoperative pathology confirmed this prediction. CONCLUSIONWe present a patient with IgG4-RD with colon involvement, which is an uncommon site. This report will expand the understanding of IgG4-RD in unknown tissues.
doi_str_mv 10.4240/wjgs.v14.i10.1169
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It affects most parts of the body; however, there are not many reports on IgG4-RD involving the colon. CASE SUMMARYA 50-year-old man complaining of intermittent fever for more than two years was referred to our hospital. Based on various investigations before surgery, we diagnosed him with chronic perforation of the sigmoid colon caused by inflammatory change or tumor. IgG blood tests before the operation suggested IgG4-RD, and postoperative pathology confirmed this prediction. CONCLUSIONWe present a patient with IgG4-RD with colon involvement, which is an uncommon site. 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source Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
title Immunoglobulin G4-related disease in the sigmoid colon in patient with severe colonic fibrosis and obstruction: A case report
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