Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters
Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that extract lowered HUA in animals. However, the active ingredient and pharmacological mechanism of extract in the improvement of HUA are unknown. The purpose of this stu...
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| Veröffentlicht in: | Food & function 2022-12, Vol.13 (24), p.12619-12631 |
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| creator | Lin, Simei Meng, Jia Li, Fei Yu, Huifan Lin, Dongmei Lin, Shuqian Li, Min Zhou, Hong Yang, Baoxue |
| description | Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that
extract lowered HUA in animals. However, the active ingredient and pharmacological mechanism of
extract in the improvement of HUA are unknown. The purpose of this study was to determine the anti-HUA efficacy and related mechanism of
polysaccharide peptide (GLPP) using a potassium oxonate (PO)-induced mouse model and an adenosine-induced cell model. The experimental results showed that blood uric acid (UA) was decreased up to 40.6% by GLPP in HUA mice in a dose-dependent manner. Additionally, GLPP significantly reduced UA production by inhibiting the hepatic and blood adenosine deaminase (ADA) activity and increased UA excretion by decreasing the expression of glucose transporter 9 (GLUT9) and increasing the expression of organic anion transporter 1 (OAT1) in kidney. The adenosine-induced cell model showed that the inhibitory effect of GLPP on ADA activity may be the main reason for the alleviation of HUA by GLPP. Furthermore, PO-induced renal histopathological damage was also alleviated by GLPP in a dose-dependent manner. The experimental results in this study indicated that GLPP exerted anti-HUA effects
regulating the UA production and excretion, suggesting that GLPP could be developed into a therapeutic agent for HUA. |
| doi_str_mv | 10.1039/d2fo02431d |
| format | Article |
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extract lowered HUA in animals. However, the active ingredient and pharmacological mechanism of
extract in the improvement of HUA are unknown. The purpose of this study was to determine the anti-HUA efficacy and related mechanism of
polysaccharide peptide (GLPP) using a potassium oxonate (PO)-induced mouse model and an adenosine-induced cell model. The experimental results showed that blood uric acid (UA) was decreased up to 40.6% by GLPP in HUA mice in a dose-dependent manner. Additionally, GLPP significantly reduced UA production by inhibiting the hepatic and blood adenosine deaminase (ADA) activity and increased UA excretion by decreasing the expression of glucose transporter 9 (GLUT9) and increasing the expression of organic anion transporter 1 (OAT1) in kidney. The adenosine-induced cell model showed that the inhibitory effect of GLPP on ADA activity may be the main reason for the alleviation of HUA by GLPP. Furthermore, PO-induced renal histopathological damage was also alleviated by GLPP in a dose-dependent manner. The experimental results in this study indicated that GLPP exerted anti-HUA effects
regulating the UA production and excretion, suggesting that GLPP could be developed into a therapeutic agent for HUA.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d2fo02431d</identifier><identifier>PMID: 36385640</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adenosine ; Adenosine - pharmacology ; Adenosine deaminase ; Adenosine Deaminase - metabolism ; Animals ; Blood ; Chemical compounds ; Chronic illnesses ; Excretion ; Ganoderma lucidum ; Glucose transporter ; Humans ; Hyperuricemia ; Hyperuricemia - therapy ; Kidney - drug effects ; Kidneys ; Mice ; Mushrooms ; Organic Anion Transporters - metabolism ; Pathogenesis ; Peptides ; Pharmacology ; Polysaccharides ; Potassium ; Proteoglycans - isolation & purification ; Proteoglycans - pharmacology ; Proteoglycans - therapeutic use ; Reishi - chemistry ; Uric acid</subject><ispartof>Food & function, 2022-12, Vol.13 (24), p.12619-12631</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8a8a22482a503bc373f8d7e7bd686e81fb90f422b761130ca158d88854ac92273</citedby><cites>FETCH-LOGICAL-c356t-8a8a22482a503bc373f8d7e7bd686e81fb90f422b761130ca158d88854ac92273</cites><orcidid>0000-0002-7966-2095</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36385640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Simei</creatorcontrib><creatorcontrib>Meng, Jia</creatorcontrib><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Yu, Huifan</creatorcontrib><creatorcontrib>Lin, Dongmei</creatorcontrib><creatorcontrib>Lin, Shuqian</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Yang, Baoxue</creatorcontrib><title>Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that
extract lowered HUA in animals. However, the active ingredient and pharmacological mechanism of
extract in the improvement of HUA are unknown. The purpose of this study was to determine the anti-HUA efficacy and related mechanism of
polysaccharide peptide (GLPP) using a potassium oxonate (PO)-induced mouse model and an adenosine-induced cell model. The experimental results showed that blood uric acid (UA) was decreased up to 40.6% by GLPP in HUA mice in a dose-dependent manner. Additionally, GLPP significantly reduced UA production by inhibiting the hepatic and blood adenosine deaminase (ADA) activity and increased UA excretion by decreasing the expression of glucose transporter 9 (GLUT9) and increasing the expression of organic anion transporter 1 (OAT1) in kidney. The adenosine-induced cell model showed that the inhibitory effect of GLPP on ADA activity may be the main reason for the alleviation of HUA by GLPP. Furthermore, PO-induced renal histopathological damage was also alleviated by GLPP in a dose-dependent manner. The experimental results in this study indicated that GLPP exerted anti-HUA effects
regulating the UA production and excretion, suggesting that GLPP could be developed into a therapeutic agent for HUA.</description><subject>Adenosine</subject><subject>Adenosine - pharmacology</subject><subject>Adenosine deaminase</subject><subject>Adenosine Deaminase - metabolism</subject><subject>Animals</subject><subject>Blood</subject><subject>Chemical compounds</subject><subject>Chronic illnesses</subject><subject>Excretion</subject><subject>Ganoderma lucidum</subject><subject>Glucose transporter</subject><subject>Humans</subject><subject>Hyperuricemia</subject><subject>Hyperuricemia - therapy</subject><subject>Kidney - drug effects</subject><subject>Kidneys</subject><subject>Mice</subject><subject>Mushrooms</subject><subject>Organic Anion Transporters - metabolism</subject><subject>Pathogenesis</subject><subject>Peptides</subject><subject>Pharmacology</subject><subject>Polysaccharides</subject><subject>Potassium</subject><subject>Proteoglycans - isolation & purification</subject><subject>Proteoglycans - pharmacology</subject><subject>Proteoglycans - therapeutic use</subject><subject>Reishi - chemistry</subject><subject>Uric acid</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r3DAQxUVoSJYkl3yAIuilBLaRJVmWj2XTpIVALgnkZsbSeFfBllzJKmw_fZR_PXQubw6_9xjmEXJesW8VE-2l5UNgXIrKHpAVZ5KvVc0eP33sslXH5CylJ1ZGtK1u9RE5FkroWkm2In9vwAeLcQI6ZuNsnugcxn0CY3YQnUU647y8KIwj_nGwYKK7_YwxR2dwckD7PY24zSMszm8pWPQhOY_UIkzOQypWb2mOxUqXCD7NIS4Y0yk5HGBMePauJ-Th-sf95uf69u7m1-b77dqIWi1rDRo4l5pDzURvRCMGbRtsequ0Ql0NfcsGyXnfqKoSzEBVa6u1riWYlvNGnJCvb7lzDL8zpqWbXDI4juAx5NQVpJFKsVYW9Mt_6FPI0ZfrClWL8kyl60JdvFEmhpQiDt0c3QRx31Wseymlu-LXd6-lXBX483tk7ie0_9CPCsQzomaI1w</recordid><startdate>20221213</startdate><enddate>20221213</enddate><creator>Lin, Simei</creator><creator>Meng, Jia</creator><creator>Li, Fei</creator><creator>Yu, Huifan</creator><creator>Lin, Dongmei</creator><creator>Lin, Shuqian</creator><creator>Li, Min</creator><creator>Zhou, Hong</creator><creator>Yang, Baoxue</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7966-2095</orcidid></search><sort><creationdate>20221213</creationdate><title>Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters</title><author>Lin, Simei ; Meng, Jia ; Li, Fei ; Yu, Huifan ; Lin, Dongmei ; Lin, Shuqian ; Li, Min ; Zhou, Hong ; Yang, Baoxue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8a8a22482a503bc373f8d7e7bd686e81fb90f422b761130ca158d88854ac92273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenosine</topic><topic>Adenosine - pharmacology</topic><topic>Adenosine deaminase</topic><topic>Adenosine Deaminase - metabolism</topic><topic>Animals</topic><topic>Blood</topic><topic>Chemical compounds</topic><topic>Chronic illnesses</topic><topic>Excretion</topic><topic>Ganoderma lucidum</topic><topic>Glucose transporter</topic><topic>Humans</topic><topic>Hyperuricemia</topic><topic>Hyperuricemia - therapy</topic><topic>Kidney - drug effects</topic><topic>Kidneys</topic><topic>Mice</topic><topic>Mushrooms</topic><topic>Organic Anion Transporters - metabolism</topic><topic>Pathogenesis</topic><topic>Peptides</topic><topic>Pharmacology</topic><topic>Polysaccharides</topic><topic>Potassium</topic><topic>Proteoglycans - isolation & purification</topic><topic>Proteoglycans - pharmacology</topic><topic>Proteoglycans - therapeutic use</topic><topic>Reishi - chemistry</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Simei</creatorcontrib><creatorcontrib>Meng, Jia</creatorcontrib><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Yu, Huifan</creatorcontrib><creatorcontrib>Lin, Dongmei</creatorcontrib><creatorcontrib>Lin, Shuqian</creatorcontrib><creatorcontrib>Li, Min</creatorcontrib><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Yang, Baoxue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Simei</au><au>Meng, Jia</au><au>Li, Fei</au><au>Yu, Huifan</au><au>Lin, Dongmei</au><au>Lin, Shuqian</au><au>Li, Min</au><au>Zhou, Hong</au><au>Yang, Baoxue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2022-12-13</date><risdate>2022</risdate><volume>13</volume><issue>24</issue><spage>12619</spage><epage>12631</epage><pages>12619-12631</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that
extract lowered HUA in animals. However, the active ingredient and pharmacological mechanism of
extract in the improvement of HUA are unknown. The purpose of this study was to determine the anti-HUA efficacy and related mechanism of
polysaccharide peptide (GLPP) using a potassium oxonate (PO)-induced mouse model and an adenosine-induced cell model. The experimental results showed that blood uric acid (UA) was decreased up to 40.6% by GLPP in HUA mice in a dose-dependent manner. Additionally, GLPP significantly reduced UA production by inhibiting the hepatic and blood adenosine deaminase (ADA) activity and increased UA excretion by decreasing the expression of glucose transporter 9 (GLUT9) and increasing the expression of organic anion transporter 1 (OAT1) in kidney. The adenosine-induced cell model showed that the inhibitory effect of GLPP on ADA activity may be the main reason for the alleviation of HUA by GLPP. Furthermore, PO-induced renal histopathological damage was also alleviated by GLPP in a dose-dependent manner. The experimental results in this study indicated that GLPP exerted anti-HUA effects
regulating the UA production and excretion, suggesting that GLPP could be developed into a therapeutic agent for HUA.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36385640</pmid><doi>10.1039/d2fo02431d</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-7966-2095</orcidid></addata></record> |
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| subjects | Adenosine Adenosine - pharmacology Adenosine deaminase Adenosine Deaminase - metabolism Animals Blood Chemical compounds Chronic illnesses Excretion Ganoderma lucidum Glucose transporter Humans Hyperuricemia Hyperuricemia - therapy Kidney - drug effects Kidneys Mice Mushrooms Organic Anion Transporters - metabolism Pathogenesis Peptides Pharmacology Polysaccharides Potassium Proteoglycans - isolation & purification Proteoglycans - pharmacology Proteoglycans - therapeutic use Reishi - chemistry Uric acid |
| title | Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters |
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