AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

Nutrient sensing and damage sensing are two fundamental processes in living organisms. While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial infection, how body glucose levels affect innate immune responses to microbial invasion is not fully understood. Here, we sur...

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Veröffentlicht in:	Molecular cell 2022-12, Vol.82 (23), p.4519-4536.e7
Hauptverfasser:	Zhang, Qian, Liu, Shengduo, Zhang, Chen-Song, Wu, Qirou, Yu, Xinyuan, Zhou, Ruyuan, Meng, Fansen, Wang, Ailian, Zhang, Fei, Chen, Shasha, Wang, Xiaojian, Li, Lei, Huang, Jun, Huang, Yao-Wei, Zou, Jian, Qin, Jun, Liang, Tingbo, Feng, Xin-Hua, Lin, Sheng-Cai, Xu, Pinglong
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMPK Animals antiviral immunity blood glucose cGAS-STING coronavirus Glucose glucose metabolism hyperglycemia Immunity, Innate innate immunity Nucleic Acids signalosome TBK1 viral infection virus-host interactions
Online-Zugang:	Volltext
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