Microbial Community Structure of Colostrum in Women with Antibiotic Exposure Immediately After Delivery
The microbial community in human milk is associated with many maternal and neonatal factors. This study aimed to investigate the effect of antibiotic exposure on the microbial community structure of colostrum. Twenty women with antibiotic treatment immediately after delivery and 10 age-matched contr...
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| Veröffentlicht in: | Breastfeeding medicine 2022-11, Vol.17 (11), p.940-946 |
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| creator | Wang, Yanli Wang, Junping Yu, Dongling Zou, Jingjing Zhang, Chunyi Yan, Huiheng Ye, Xiuzhen Chen, Yunbin |
| description | The microbial community in human milk is associated with many maternal and neonatal factors. This study aimed to investigate the effect of antibiotic exposure on the microbial community structure of colostrum.
Twenty women with antibiotic treatment immediately after delivery and 10 age-matched control women were enrolled at the Guangdong Women and Children Hospital. Colostrum samples were collected within postpartum 30 hours. The V4 variable region of the bacterial 16S rRNA gene was sequenced to characterize the microbial profile using Illumina MiSeq platform.
Phyla
and
were the predominant bacteria in colostrum samples. The core and abundant genera in colostrum included
,
, and
. Compared with the control group, principal coordinate analysis based on the Bray-Curtis distance showed a significant difference in milk microbial community in women with antibiotic exposure, accompanied by a significantly lower alpha diversity and a different microbial ecological network. Furthermore, the relative abundances of genera
,
, and
sensu
significantly decreased after antibiotic treatment.
This study provided evidence of alterations in the colostrum microbial community with antibiotic exposure, improving our understanding of the effects of antibiotic treatment on the milk microbiome. |
| doi_str_mv | 10.1089/bfm.2022.0140 |
| format | Article |
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Twenty women with antibiotic treatment immediately after delivery and 10 age-matched control women were enrolled at the Guangdong Women and Children Hospital. Colostrum samples were collected within postpartum 30 hours. The V4 variable region of the bacterial 16S rRNA gene was sequenced to characterize the microbial profile using Illumina MiSeq platform.
Phyla
and
were the predominant bacteria in colostrum samples. The core and abundant genera in colostrum included
,
, and
. Compared with the control group, principal coordinate analysis based on the Bray-Curtis distance showed a significant difference in milk microbial community in women with antibiotic exposure, accompanied by a significantly lower alpha diversity and a different microbial ecological network. Furthermore, the relative abundances of genera
,
, and
sensu
significantly decreased after antibiotic treatment.
This study provided evidence of alterations in the colostrum microbial community with antibiotic exposure, improving our understanding of the effects of antibiotic treatment on the milk microbiome.</description><identifier>ISSN: 1556-8253</identifier><identifier>EISSN: 1556-8342</identifier><identifier>DOI: 10.1089/bfm.2022.0140</identifier><identifier>PMID: 36378822</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Breast Feeding ; Breastfeeding & lactation ; Child ; Colostrum ; Female ; Humans ; Infant, Newborn ; Microbiota ; Milk ; Milk, Human - microbiology ; Pregnancy ; RNA, Ribosomal, 16S - genetics ; Womens health</subject><ispartof>Breastfeeding medicine, 2022-11, Vol.17 (11), p.940-946</ispartof><rights>Copyright Mary Ann Liebert, Inc. Nov 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c277t-108fa8d7e853a3b9cf34c0feb24c34e971eff48c77b5c9d998f6a839a8e5bbb83</cites><orcidid>0000-0002-4113-7834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36378822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yanli</creatorcontrib><creatorcontrib>Wang, Junping</creatorcontrib><creatorcontrib>Yu, Dongling</creatorcontrib><creatorcontrib>Zou, Jingjing</creatorcontrib><creatorcontrib>Zhang, Chunyi</creatorcontrib><creatorcontrib>Yan, Huiheng</creatorcontrib><creatorcontrib>Ye, Xiuzhen</creatorcontrib><creatorcontrib>Chen, Yunbin</creatorcontrib><title>Microbial Community Structure of Colostrum in Women with Antibiotic Exposure Immediately After Delivery</title><title>Breastfeeding medicine</title><addtitle>Breastfeed Med</addtitle><description>The microbial community in human milk is associated with many maternal and neonatal factors. This study aimed to investigate the effect of antibiotic exposure on the microbial community structure of colostrum.
Twenty women with antibiotic treatment immediately after delivery and 10 age-matched control women were enrolled at the Guangdong Women and Children Hospital. Colostrum samples were collected within postpartum 30 hours. The V4 variable region of the bacterial 16S rRNA gene was sequenced to characterize the microbial profile using Illumina MiSeq platform.
Phyla
and
were the predominant bacteria in colostrum samples. The core and abundant genera in colostrum included
,
, and
. Compared with the control group, principal coordinate analysis based on the Bray-Curtis distance showed a significant difference in milk microbial community in women with antibiotic exposure, accompanied by a significantly lower alpha diversity and a different microbial ecological network. Furthermore, the relative abundances of genera
,
, and
sensu
significantly decreased after antibiotic treatment.
This study provided evidence of alterations in the colostrum microbial community with antibiotic exposure, improving our understanding of the effects of antibiotic treatment on the milk microbiome.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Breast Feeding</subject><subject>Breastfeeding & lactation</subject><subject>Child</subject><subject>Colostrum</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Microbiota</subject><subject>Milk</subject><subject>Milk, Human - microbiology</subject><subject>Pregnancy</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Womens health</subject><issn>1556-8253</issn><issn>1556-8342</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkb1vFDEQxS1EREKgpEWWaNLs4a9d2-XpEiBSUApAlCvbNwZH6_Vhewn33-NVEgqqGT399DTzHkJvKNlQovR76-OGEcY2hAryDJ3Rvh86xQV7_rSznp-il6XcESJ6OogX6JQPXCrF2Bn68Tm4nGwwE96lGJc51CP-UvPi6pIBJ9_kKZUmRBxm_D1FmPF9qD_xdq7BhlSDw1d_Dqms-HWMsA-mwnTEW18h40uYwm_Ix1foxJupwOvHeY6-fbj6uvvU3dx-vN5tbzrHpKxde8kbtZegem641c5z4YgHy4TjArSk4L1QTkrbO73XWvnBKK6Ngt5aq_g5unjwPeT0a4FSxxiKg2kyM6SljExySakeNG3ou__Qu7TkuV23UgMXWsvVsHugWkylZPDjIYdo8nGkZFwbGFsD49rAuDbQ-LeProttYfyjnyLnfwGboILf</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Wang, Yanli</creator><creator>Wang, Junping</creator><creator>Yu, Dongling</creator><creator>Zou, Jingjing</creator><creator>Zhang, Chunyi</creator><creator>Yan, Huiheng</creator><creator>Ye, Xiuzhen</creator><creator>Chen, Yunbin</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4113-7834</orcidid></search><sort><creationdate>202211</creationdate><title>Microbial Community Structure of Colostrum in Women with Antibiotic Exposure Immediately After Delivery</title><author>Wang, Yanli ; Wang, Junping ; Yu, Dongling ; Zou, Jingjing ; Zhang, Chunyi ; Yan, Huiheng ; Ye, Xiuzhen ; Chen, Yunbin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-108fa8d7e853a3b9cf34c0feb24c34e971eff48c77b5c9d998f6a839a8e5bbb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Breast Feeding</topic><topic>Breastfeeding & lactation</topic><topic>Child</topic><topic>Colostrum</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Microbiota</topic><topic>Milk</topic><topic>Milk, Human - microbiology</topic><topic>Pregnancy</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yanli</creatorcontrib><creatorcontrib>Wang, Junping</creatorcontrib><creatorcontrib>Yu, Dongling</creatorcontrib><creatorcontrib>Zou, Jingjing</creatorcontrib><creatorcontrib>Zhang, Chunyi</creatorcontrib><creatorcontrib>Yan, Huiheng</creatorcontrib><creatorcontrib>Ye, Xiuzhen</creatorcontrib><creatorcontrib>Chen, Yunbin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Breastfeeding medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yanli</au><au>Wang, Junping</au><au>Yu, Dongling</au><au>Zou, Jingjing</au><au>Zhang, Chunyi</au><au>Yan, Huiheng</au><au>Ye, Xiuzhen</au><au>Chen, Yunbin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbial Community Structure of Colostrum in Women with Antibiotic Exposure Immediately After Delivery</atitle><jtitle>Breastfeeding medicine</jtitle><addtitle>Breastfeed Med</addtitle><date>2022-11</date><risdate>2022</risdate><volume>17</volume><issue>11</issue><spage>940</spage><epage>946</epage><pages>940-946</pages><issn>1556-8253</issn><eissn>1556-8342</eissn><abstract>The microbial community in human milk is associated with many maternal and neonatal factors. This study aimed to investigate the effect of antibiotic exposure on the microbial community structure of colostrum.
Twenty women with antibiotic treatment immediately after delivery and 10 age-matched control women were enrolled at the Guangdong Women and Children Hospital. Colostrum samples were collected within postpartum 30 hours. The V4 variable region of the bacterial 16S rRNA gene was sequenced to characterize the microbial profile using Illumina MiSeq platform.
Phyla
and
were the predominant bacteria in colostrum samples. The core and abundant genera in colostrum included
,
, and
. Compared with the control group, principal coordinate analysis based on the Bray-Curtis distance showed a significant difference in milk microbial community in women with antibiotic exposure, accompanied by a significantly lower alpha diversity and a different microbial ecological network. Furthermore, the relative abundances of genera
,
, and
sensu
significantly decreased after antibiotic treatment.
This study provided evidence of alterations in the colostrum microbial community with antibiotic exposure, improving our understanding of the effects of antibiotic treatment on the milk microbiome.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>36378822</pmid><doi>10.1089/bfm.2022.0140</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4113-7834</orcidid></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - therapeutic use Antibiotics Breast Feeding Breastfeeding & lactation Child Colostrum Female Humans Infant, Newborn Microbiota Milk Milk, Human - microbiology Pregnancy RNA, Ribosomal, 16S - genetics Womens health |
| title | Microbial Community Structure of Colostrum in Women with Antibiotic Exposure Immediately After Delivery |
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