Intra‐ and Intermolecular Cooperativity in the Catalytic Activity of Phosphodiester Cleavage by Self‐Assembled Systems Based on Guanidinylated Calix[4]arenes

The calix[4]arene scaffold, blocked in the cone conformation through alkylation with long alkyl chains, and decorated at the upper rim with four guanidine or arginine units, effectively catalyzes the cleavage of the phosphodiester bond of DNA and RNA model compounds in water. An exhaustive kinetic i...

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Veröffentlicht in:	Chemistry : a European journal 2023-02, Vol.29 (12), p.e202203213-n/a
Hauptverfasser:	Lisi, Daniele, Vezzoni, Carlo Alberto, Casnati, Alessandro, Sansone, Francesco, Salvio, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	artificial phosphodiesterases calixarenes enzyme mimics self-assembling supramolecular catalysis
Online-Zugang:	Volltext
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