Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study
Objectives To investigate the clinical features and factors associated with primary Sjögren’s syndrome (pSS)–associated renal tubular acidosis (RTA). Method This case–control study was based on a multicenter pSS registry established by the Chinese Rheumatism Data Center. Patients with pSS, including...
Gespeichert in:
| Veröffentlicht in: | Clinical rheumatology 2023-02, Vol.42 (2), p.431-441 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 441 |
|---|---|
| container_issue | 2 |
| container_start_page | 431 |
| container_title | Clinical rheumatology |
| container_volume | 42 |
| creator | Zhang, Yuying Qiao, Lin Zhang, Liyun Li, Qin Yang, Pinting Kong, Xiaodan Duan, Xinwang Zhang, Miaojia Li, Xiaomei Wang, Yongfu Xu, Jian Wang, Yanhong Hsieh, Evelyn Zhao, Jiuliang Xu, Dong Li, Mengtao Zhao, Yan Zeng, Xiaofeng |
| description | Objectives
To investigate the clinical features and factors associated with primary Sjögren’s syndrome (pSS)–associated renal tubular acidosis (RTA).
Method
This case–control study was based on a multicenter pSS registry established by the Chinese Rheumatism Data Center. Patients with pSS, including those with RTA and those without renal involvement, between May 2016 and March 2020 were included in the analysis. Demographic, clinical, and laboratory data were also collected. Univariate and multivariate logistic regression analyses were used to identify factors that were associated with pSS-RTA.
Results
This study included 257 pSS patients with RTA and 4222 patients without renal involvement. Significantly younger age at disease onset (40.1 ± 14.1 vs. 46.2 ± 13.1 years,
P
|
| doi_str_mv | 10.1007/s10067-022-06426-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2737117243</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2737117243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-7f84b7930b70a90a392afd1f181c2c61e2c79f78072b2d836233eb83938a03793</originalsourceid><addsrcrecordid>eNp9kUtuFDEURS1ElDRJNsAAWWKSiYntV_GHGYoIIEWKxGdsuVyuxq3qqsbPJdQztsFGsoHshJXgpJsgMWBiD3zutd47hDwX_JXgXJ9jPZVmXErGVSMVk0_IQjTQMGsb-5QsuNacgbDmiDxDXHHOpbHikByBAgMS7IKUj3H0Ay1zOw8-Ux9SN2FC6seOesQpJF9iR3sfypSRppFufElxLEi_p_KVbnJa-7yln1Z3t8scx18_fiLF7djlaR1fU09zXCYsectaj7UIy9xtT8hB7weMp_v7mHy5evv58j27vnn34fLNNQugLwrTvWlabYG3mnvLPVjp-070wogggxJRBm17bbiWrewMKAkQWwMWjOdQg8fkbNe7ydO3OWJx64QhDoMf4zSjkxq0EFo2UNGX_6Crac51NfeUqlu7EEpVSu6okCfEHHu3n98J7u6duJ0TV524BydO1tCLffXcrmP3GPkjoQKwA7A-jcuY__79n9rfpcGY8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2768915166</pqid></control><display><type>article</type><title>Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zhang, Yuying ; Qiao, Lin ; Zhang, Liyun ; Li, Qin ; Yang, Pinting ; Kong, Xiaodan ; Duan, Xinwang ; Zhang, Miaojia ; Li, Xiaomei ; Wang, Yongfu ; Xu, Jian ; Wang, Yanhong ; Hsieh, Evelyn ; Zhao, Jiuliang ; Xu, Dong ; Li, Mengtao ; Zhao, Yan ; Zeng, Xiaofeng</creator><creatorcontrib>Zhang, Yuying ; Qiao, Lin ; Zhang, Liyun ; Li, Qin ; Yang, Pinting ; Kong, Xiaodan ; Duan, Xinwang ; Zhang, Miaojia ; Li, Xiaomei ; Wang, Yongfu ; Xu, Jian ; Wang, Yanhong ; Hsieh, Evelyn ; Zhao, Jiuliang ; Xu, Dong ; Li, Mengtao ; Zhao, Yan ; Zeng, Xiaofeng</creatorcontrib><description>Objectives
To investigate the clinical features and factors associated with primary Sjögren’s syndrome (pSS)–associated renal tubular acidosis (RTA).
Method
This case–control study was based on a multicenter pSS registry established by the Chinese Rheumatism Data Center. Patients with pSS, including those with RTA and those without renal involvement, between May 2016 and March 2020 were included in the analysis. Demographic, clinical, and laboratory data were also collected. Univariate and multivariate logistic regression analyses were used to identify factors that were associated with pSS-RTA.
Results
This study included 257 pSS patients with RTA and 4222 patients without renal involvement. Significantly younger age at disease onset (40.1 ± 14.1 vs. 46.2 ± 13.1 years,
P
< 0.001), longer diagnosis interval (15.0 interquartile range [IQR] [1.0, 48.0] vs. 6.0 IQR [0, 34.0] months,
P
< 0.001), higher EULAR Sjögren’s syndrome disease activity index (9 IQR [5, 15] vs. 3 IQR [0, 8],
P
< 0.001), and a higher prevalence of decreased estimated glomerular filtration rate (25.0% vs. 6.6%,
P
< 0.001) were observed in pSS patients with RTA than in those without renal involvement. Factors that were independently associated with pSS-RTA included age at disease onset ≤ 35 years (odds ratio [OR] 3.00, 95% confidence interval [CI] 2.27–3.97), thyroid disorders (OR 1.49, 95% CI 1.04–2.14), subjective dry mouth (OR 3.29, 95% CI 1.71–6.35), arthritis (OR 1.57, 95% CI 1.10–2.25), anti-SSB antibody positivity (OR 1.80, 95% CI 1.33–2.45), anemia (OR 1.67, 95% CI 1.26–2.21), elevated alkaline phosphatase level (OR 2.14, 95% CI 1.26–3.65), decreased albumin level (OR 1.61, 95% CI 1.00–2.60), and elevated erythrocyte sedimentation rate (OR 1.78, 95% CI 1.16–2.73).
Conclusions
Delayed diagnosis and decreased kidney function are common in pSS patients with RTA. pSS should be considered in patients with RTA, and early recognition and treatment may be useful in slowing the deterioration of renal function in patients with pSS-RTA.
Key Points
•
pSS patients with RTA have earlier disease onset and higher disease activity than pSS patients without RTA, but the diagnosis was frequently delayed
.
•
Decreased kidney function are common in pSS patients with RTA
.
•
Sjögren’s syndrome should be considered in young female patients with unexplained RTA, whereas RTA should be screened in pSS patients with early disease onset and elevated ALP level
.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-022-06426-2</identifier><identifier>PMID: 36383239</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acidosis ; Acidosis, Renal Tubular - complications ; Acidosis, Renal Tubular - diagnosis ; Acidosis, Renal Tubular - epidemiology ; Adult ; Alkaline phosphatase ; Arthritis ; Arthritis - complications ; Case-Control Studies ; Diagnosis ; Erythrocyte sedimentation rate ; Female ; Glomerular filtration rate ; Humans ; Kidneys ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Patients ; Renal function ; Renal tubular acidosis ; Rheumatology ; Sjogren's syndrome ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - diagnosis ; Sjogren's Syndrome - epidemiology ; Xerostomia</subject><ispartof>Clinical rheumatology, 2023-02, Vol.42 (2), p.431-441</ispartof><rights>The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-7f84b7930b70a90a392afd1f181c2c61e2c79f78072b2d836233eb83938a03793</citedby><cites>FETCH-LOGICAL-c375t-7f84b7930b70a90a392afd1f181c2c61e2c79f78072b2d836233eb83938a03793</cites><orcidid>0000-0002-6413-3043</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-022-06426-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-022-06426-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27925,27926,41489,42558,51320</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36383239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yuying</creatorcontrib><creatorcontrib>Qiao, Lin</creatorcontrib><creatorcontrib>Zhang, Liyun</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Yang, Pinting</creatorcontrib><creatorcontrib>Kong, Xiaodan</creatorcontrib><creatorcontrib>Duan, Xinwang</creatorcontrib><creatorcontrib>Zhang, Miaojia</creatorcontrib><creatorcontrib>Li, Xiaomei</creatorcontrib><creatorcontrib>Wang, Yongfu</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><creatorcontrib>Wang, Yanhong</creatorcontrib><creatorcontrib>Hsieh, Evelyn</creatorcontrib><creatorcontrib>Zhao, Jiuliang</creatorcontrib><creatorcontrib>Xu, Dong</creatorcontrib><creatorcontrib>Li, Mengtao</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Zeng, Xiaofeng</creatorcontrib><title>Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objectives
To investigate the clinical features and factors associated with primary Sjögren’s syndrome (pSS)–associated renal tubular acidosis (RTA).
Method
This case–control study was based on a multicenter pSS registry established by the Chinese Rheumatism Data Center. Patients with pSS, including those with RTA and those without renal involvement, between May 2016 and March 2020 were included in the analysis. Demographic, clinical, and laboratory data were also collected. Univariate and multivariate logistic regression analyses were used to identify factors that were associated with pSS-RTA.
Results
This study included 257 pSS patients with RTA and 4222 patients without renal involvement. Significantly younger age at disease onset (40.1 ± 14.1 vs. 46.2 ± 13.1 years,
P
< 0.001), longer diagnosis interval (15.0 interquartile range [IQR] [1.0, 48.0] vs. 6.0 IQR [0, 34.0] months,
P
< 0.001), higher EULAR Sjögren’s syndrome disease activity index (9 IQR [5, 15] vs. 3 IQR [0, 8],
P
< 0.001), and a higher prevalence of decreased estimated glomerular filtration rate (25.0% vs. 6.6%,
P
< 0.001) were observed in pSS patients with RTA than in those without renal involvement. Factors that were independently associated with pSS-RTA included age at disease onset ≤ 35 years (odds ratio [OR] 3.00, 95% confidence interval [CI] 2.27–3.97), thyroid disorders (OR 1.49, 95% CI 1.04–2.14), subjective dry mouth (OR 3.29, 95% CI 1.71–6.35), arthritis (OR 1.57, 95% CI 1.10–2.25), anti-SSB antibody positivity (OR 1.80, 95% CI 1.33–2.45), anemia (OR 1.67, 95% CI 1.26–2.21), elevated alkaline phosphatase level (OR 2.14, 95% CI 1.26–3.65), decreased albumin level (OR 1.61, 95% CI 1.00–2.60), and elevated erythrocyte sedimentation rate (OR 1.78, 95% CI 1.16–2.73).
Conclusions
Delayed diagnosis and decreased kidney function are common in pSS patients with RTA. pSS should be considered in patients with RTA, and early recognition and treatment may be useful in slowing the deterioration of renal function in patients with pSS-RTA.
Key Points
•
pSS patients with RTA have earlier disease onset and higher disease activity than pSS patients without RTA, but the diagnosis was frequently delayed
.
•
Decreased kidney function are common in pSS patients with RTA
.
•
Sjögren’s syndrome should be considered in young female patients with unexplained RTA, whereas RTA should be screened in pSS patients with early disease onset and elevated ALP level
.</description><subject>Acidosis</subject><subject>Acidosis, Renal Tubular - complications</subject><subject>Acidosis, Renal Tubular - diagnosis</subject><subject>Acidosis, Renal Tubular - epidemiology</subject><subject>Adult</subject><subject>Alkaline phosphatase</subject><subject>Arthritis</subject><subject>Arthritis - complications</subject><subject>Case-Control Studies</subject><subject>Diagnosis</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Patients</subject><subject>Renal function</subject><subject>Renal tubular acidosis</subject><subject>Rheumatology</subject><subject>Sjogren's syndrome</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - diagnosis</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>Xerostomia</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtuFDEURS1ElDRJNsAAWWKSiYntV_GHGYoIIEWKxGdsuVyuxq3qqsbPJdQztsFGsoHshJXgpJsgMWBiD3zutd47hDwX_JXgXJ9jPZVmXErGVSMVk0_IQjTQMGsb-5QsuNacgbDmiDxDXHHOpbHikByBAgMS7IKUj3H0Ay1zOw8-Ux9SN2FC6seOesQpJF9iR3sfypSRppFufElxLEi_p_KVbnJa-7yln1Z3t8scx18_fiLF7djlaR1fU09zXCYsectaj7UIy9xtT8hB7weMp_v7mHy5evv58j27vnn34fLNNQugLwrTvWlabYG3mnvLPVjp-070wogggxJRBm17bbiWrewMKAkQWwMWjOdQg8fkbNe7ydO3OWJx64QhDoMf4zSjkxq0EFo2UNGX_6Crac51NfeUqlu7EEpVSu6okCfEHHu3n98J7u6duJ0TV524BydO1tCLffXcrmP3GPkjoQKwA7A-jcuY__79n9rfpcGY8g</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Zhang, Yuying</creator><creator>Qiao, Lin</creator><creator>Zhang, Liyun</creator><creator>Li, Qin</creator><creator>Yang, Pinting</creator><creator>Kong, Xiaodan</creator><creator>Duan, Xinwang</creator><creator>Zhang, Miaojia</creator><creator>Li, Xiaomei</creator><creator>Wang, Yongfu</creator><creator>Xu, Jian</creator><creator>Wang, Yanhong</creator><creator>Hsieh, Evelyn</creator><creator>Zhao, Jiuliang</creator><creator>Xu, Dong</creator><creator>Li, Mengtao</creator><creator>Zhao, Yan</creator><creator>Zeng, Xiaofeng</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6413-3043</orcidid></search><sort><creationdate>20230201</creationdate><title>Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study</title><author>Zhang, Yuying ; Qiao, Lin ; Zhang, Liyun ; Li, Qin ; Yang, Pinting ; Kong, Xiaodan ; Duan, Xinwang ; Zhang, Miaojia ; Li, Xiaomei ; Wang, Yongfu ; Xu, Jian ; Wang, Yanhong ; Hsieh, Evelyn ; Zhao, Jiuliang ; Xu, Dong ; Li, Mengtao ; Zhao, Yan ; Zeng, Xiaofeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7f84b7930b70a90a392afd1f181c2c61e2c79f78072b2d836233eb83938a03793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acidosis</topic><topic>Acidosis, Renal Tubular - complications</topic><topic>Acidosis, Renal Tubular - diagnosis</topic><topic>Acidosis, Renal Tubular - epidemiology</topic><topic>Adult</topic><topic>Alkaline phosphatase</topic><topic>Arthritis</topic><topic>Arthritis - complications</topic><topic>Case-Control Studies</topic><topic>Diagnosis</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Glomerular filtration rate</topic><topic>Humans</topic><topic>Kidneys</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Patients</topic><topic>Renal function</topic><topic>Renal tubular acidosis</topic><topic>Rheumatology</topic><topic>Sjogren's syndrome</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - diagnosis</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>Xerostomia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yuying</creatorcontrib><creatorcontrib>Qiao, Lin</creatorcontrib><creatorcontrib>Zhang, Liyun</creatorcontrib><creatorcontrib>Li, Qin</creatorcontrib><creatorcontrib>Yang, Pinting</creatorcontrib><creatorcontrib>Kong, Xiaodan</creatorcontrib><creatorcontrib>Duan, Xinwang</creatorcontrib><creatorcontrib>Zhang, Miaojia</creatorcontrib><creatorcontrib>Li, Xiaomei</creatorcontrib><creatorcontrib>Wang, Yongfu</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><creatorcontrib>Wang, Yanhong</creatorcontrib><creatorcontrib>Hsieh, Evelyn</creatorcontrib><creatorcontrib>Zhao, Jiuliang</creatorcontrib><creatorcontrib>Xu, Dong</creatorcontrib><creatorcontrib>Li, Mengtao</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Zeng, Xiaofeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yuying</au><au>Qiao, Lin</au><au>Zhang, Liyun</au><au>Li, Qin</au><au>Yang, Pinting</au><au>Kong, Xiaodan</au><au>Duan, Xinwang</au><au>Zhang, Miaojia</au><au>Li, Xiaomei</au><au>Wang, Yongfu</au><au>Xu, Jian</au><au>Wang, Yanhong</au><au>Hsieh, Evelyn</au><au>Zhao, Jiuliang</au><au>Xu, Dong</au><au>Li, Mengtao</au><au>Zhao, Yan</au><au>Zeng, Xiaofeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>42</volume><issue>2</issue><spage>431</spage><epage>441</epage><pages>431-441</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objectives
To investigate the clinical features and factors associated with primary Sjögren’s syndrome (pSS)–associated renal tubular acidosis (RTA).
Method
This case–control study was based on a multicenter pSS registry established by the Chinese Rheumatism Data Center. Patients with pSS, including those with RTA and those without renal involvement, between May 2016 and March 2020 were included in the analysis. Demographic, clinical, and laboratory data were also collected. Univariate and multivariate logistic regression analyses were used to identify factors that were associated with pSS-RTA.
Results
This study included 257 pSS patients with RTA and 4222 patients without renal involvement. Significantly younger age at disease onset (40.1 ± 14.1 vs. 46.2 ± 13.1 years,
P
< 0.001), longer diagnosis interval (15.0 interquartile range [IQR] [1.0, 48.0] vs. 6.0 IQR [0, 34.0] months,
P
< 0.001), higher EULAR Sjögren’s syndrome disease activity index (9 IQR [5, 15] vs. 3 IQR [0, 8],
P
< 0.001), and a higher prevalence of decreased estimated glomerular filtration rate (25.0% vs. 6.6%,
P
< 0.001) were observed in pSS patients with RTA than in those without renal involvement. Factors that were independently associated with pSS-RTA included age at disease onset ≤ 35 years (odds ratio [OR] 3.00, 95% confidence interval [CI] 2.27–3.97), thyroid disorders (OR 1.49, 95% CI 1.04–2.14), subjective dry mouth (OR 3.29, 95% CI 1.71–6.35), arthritis (OR 1.57, 95% CI 1.10–2.25), anti-SSB antibody positivity (OR 1.80, 95% CI 1.33–2.45), anemia (OR 1.67, 95% CI 1.26–2.21), elevated alkaline phosphatase level (OR 2.14, 95% CI 1.26–3.65), decreased albumin level (OR 1.61, 95% CI 1.00–2.60), and elevated erythrocyte sedimentation rate (OR 1.78, 95% CI 1.16–2.73).
Conclusions
Delayed diagnosis and decreased kidney function are common in pSS patients with RTA. pSS should be considered in patients with RTA, and early recognition and treatment may be useful in slowing the deterioration of renal function in patients with pSS-RTA.
Key Points
•
pSS patients with RTA have earlier disease onset and higher disease activity than pSS patients without RTA, but the diagnosis was frequently delayed
.
•
Decreased kidney function are common in pSS patients with RTA
.
•
Sjögren’s syndrome should be considered in young female patients with unexplained RTA, whereas RTA should be screened in pSS patients with early disease onset and elevated ALP level
.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36383239</pmid><doi>10.1007/s10067-022-06426-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6413-3043</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2023-02, Vol.42 (2), p.431-441 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2737117243 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acidosis Acidosis, Renal Tubular - complications Acidosis, Renal Tubular - diagnosis Acidosis, Renal Tubular - epidemiology Adult Alkaline phosphatase Arthritis Arthritis - complications Case-Control Studies Diagnosis Erythrocyte sedimentation rate Female Glomerular filtration rate Humans Kidneys Medicine Medicine & Public Health Middle Aged Original Article Patients Renal function Renal tubular acidosis Rheumatology Sjogren's syndrome Sjogren's Syndrome - complications Sjogren's Syndrome - diagnosis Sjogren's Syndrome - epidemiology Xerostomia |
| title | Renal tubular acidosis and associated factors in patients with primary Sjögren’s syndrome: a registry-based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T14%3A12%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20tubular%20acidosis%20and%20associated%20factors%20in%20patients%20with%20primary%20Sj%C3%B6gren%E2%80%99s%20syndrome:%20a%20registry-based%20study&rft.jtitle=Clinical%20rheumatology&rft.au=Zhang,%20Yuying&rft.date=2023-02-01&rft.volume=42&rft.issue=2&rft.spage=431&rft.epage=441&rft.pages=431-441&rft.issn=0770-3198&rft.eissn=1434-9949&rft_id=info:doi/10.1007/s10067-022-06426-2&rft_dat=%3Cproquest_cross%3E2737117243%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2768915166&rft_id=info:pmid/36383239&rfr_iscdi=true |