AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the functionality of intra-tumoral Tfh cells in the 4T1 mouse model

[Display omitted] •CD4+Foxp3+CXCR5+PD1+ Tfr cells and PD-L1+ cells upregulate in the systemic circulation of 4T1 tumor-bearing mouse.•Anti-IL10 mAb potently improves Tfh cell frequency and suppressed Tfr cell proliferation in 4T1 mouse.•The addition of 2DG and Etomoxir reduced tumor growth but could...

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