Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity
Purpose To investigate the blood neutrophil-to-lymphocyte ratio (NLR) as a risk factor for retinopathy of prematurity (ROP) development or treatment. Methods Retrospective cohort study. Infants who underwent ROP screening at Shiga University of Medical Science Hospital and Omihachiman Community Medi...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2023-04, Vol.261 (4), p.951-957 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Obata, Shumpei Matsumoto, Riko Kakinoki, Masashi Sawada, Osamu Sawada, Tomoko Saishin, Yoshitsugu Yanagi, Takahide Maruo, Yoshihiro Ohji, Masahito |
| description | Purpose
To investigate the blood neutrophil-to-lymphocyte ratio (NLR) as a risk factor for retinopathy of prematurity (ROP) development or treatment.
Methods
Retrospective cohort study. Infants who underwent ROP screening at Shiga University of Medical Science Hospital and Omihachiman Community Medical Center between April 2010 and December 2021 were included in this study. Screening criteria were gestational age (GA) |
| doi_str_mv | 10.1007/s00417-022-05902-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2736666461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2736666461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c485t-c8c5ee23a05f2734d4a62dc71d4ae28210f219e971c6d85a96a9c437cac0011d3</originalsourceid><addsrcrecordid>eNp9kctKxTAQhoMoery8gAsJuHETza1Ns1TxBoIbBXchplNPtW1qki769kaPF3DhbGbIfPNnmB-hfUaPGaXqJFIqmSKUc0ILTTmRa2jBpCiIovxxHS2o4oxUgj9uoe0YX2jmRcE20ZYohaqE0AtkzzrvazzAlIIfl21Hkifd3I9L7-YEONjUemwjtji08RU31iUfcDvgFMCmHoaEm_wQILWDH21aztg3eAzQ2zSFNs27aKOxXYS9r7yDHi4v7s-vye3d1c356S1xsioScZUrALiwtGi4ErKWtuS1UywXwCvOaMOZBq2YK-uqsLq02kmhnHWUMlaLHXS00h2Df5sgJtO30UHX2QH8FE0WLXPIkmX08A_64qcw5O0ypZmqmC50pviKcsHHGKAxY2h7G2bDqPkwwKwMMNkA82mAkXno4Et6euqh_hn5vngGxAqIuTU8Q_j9-x_Zd79IkYo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2791781959</pqid></control><display><type>article</type><title>Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Obata, Shumpei ; Matsumoto, Riko ; Kakinoki, Masashi ; Sawada, Osamu ; Sawada, Tomoko ; Saishin, Yoshitsugu ; Yanagi, Takahide ; Maruo, Yoshihiro ; Ohji, Masahito</creator><creatorcontrib>Obata, Shumpei ; Matsumoto, Riko ; Kakinoki, Masashi ; Sawada, Osamu ; Sawada, Tomoko ; Saishin, Yoshitsugu ; Yanagi, Takahide ; Maruo, Yoshihiro ; Ohji, Masahito</creatorcontrib><description>Purpose
To investigate the blood neutrophil-to-lymphocyte ratio (NLR) as a risk factor for retinopathy of prematurity (ROP) development or treatment.
Methods
Retrospective cohort study. Infants who underwent ROP screening at Shiga University of Medical Science Hospital and Omihachiman Community Medical Center between April 2010 and December 2021 were included in this study. Screening criteria were gestational age (GA) < 32 weeks or birth weight (BW) < 1500 g. Multivariate logistic regression analysis was applied to investigate whether the NLR constituted an independent risk factor for ROP development or treatment. The objective variable was ROP development or treatment, and the explanatory variables were GA, BW, NLR, maternal infection or clinical chorioamnionitis and corticosteroid use by the mother. Maternal infection or clinical chorioamnionitis and corticosteroid use by the mother was included in the explanatory variables to adjust for factors affecting the NLR.
Results
In total, 220 infants met the inclusion criteria, of whom 125 developed ROP, whereas 95 infants did not display ROP. GA was significantly associated with ROP development (odds ratio (OR): 0.41,
p
< 0.001); however, the NLR was not significantly associated with ROP development (OR: 1.0,
p
= 0.74). Thirty-eight infants received treatment for ROP, whereas 182 infants had no such treatment. BW and the NLR were significantly associated with ROP treatment (OR: 1.6 and 0.66,
p
< 0.001 and 0.003, respectively).
Conclusion
The NLR was not a risk factor for ROP development but was a risk factor for ROP treatment.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-022-05902-4</identifier><identifier>PMID: 36378339</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adrenal Cortex Hormones ; Birth Weight ; Chorioamnionitis ; Female ; Gestational Age ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Very Low Birth Weight ; Infants ; Leukocytes (neutrophilic) ; Lymphocytes ; Medicine ; Medicine & Public Health ; Neutrophils ; Ophthalmology ; Retinal Disorders ; Retinopathy ; Retinopathy of Prematurity - diagnosis ; Retrospective Studies ; Risk Factors ; Steroids</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2023-04, Vol.261 (4), p.951-957</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-c8c5ee23a05f2734d4a62dc71d4ae28210f219e971c6d85a96a9c437cac0011d3</citedby><cites>FETCH-LOGICAL-c485t-c8c5ee23a05f2734d4a62dc71d4ae28210f219e971c6d85a96a9c437cac0011d3</cites><orcidid>0000-0001-6120-2392</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-022-05902-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-022-05902-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36378339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obata, Shumpei</creatorcontrib><creatorcontrib>Matsumoto, Riko</creatorcontrib><creatorcontrib>Kakinoki, Masashi</creatorcontrib><creatorcontrib>Sawada, Osamu</creatorcontrib><creatorcontrib>Sawada, Tomoko</creatorcontrib><creatorcontrib>Saishin, Yoshitsugu</creatorcontrib><creatorcontrib>Yanagi, Takahide</creatorcontrib><creatorcontrib>Maruo, Yoshihiro</creatorcontrib><creatorcontrib>Ohji, Masahito</creatorcontrib><title>Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To investigate the blood neutrophil-to-lymphocyte ratio (NLR) as a risk factor for retinopathy of prematurity (ROP) development or treatment.
Methods
Retrospective cohort study. Infants who underwent ROP screening at Shiga University of Medical Science Hospital and Omihachiman Community Medical Center between April 2010 and December 2021 were included in this study. Screening criteria were gestational age (GA) < 32 weeks or birth weight (BW) < 1500 g. Multivariate logistic regression analysis was applied to investigate whether the NLR constituted an independent risk factor for ROP development or treatment. The objective variable was ROP development or treatment, and the explanatory variables were GA, BW, NLR, maternal infection or clinical chorioamnionitis and corticosteroid use by the mother. Maternal infection or clinical chorioamnionitis and corticosteroid use by the mother was included in the explanatory variables to adjust for factors affecting the NLR.
Results
In total, 220 infants met the inclusion criteria, of whom 125 developed ROP, whereas 95 infants did not display ROP. GA was significantly associated with ROP development (odds ratio (OR): 0.41,
p
< 0.001); however, the NLR was not significantly associated with ROP development (OR: 1.0,
p
= 0.74). Thirty-eight infants received treatment for ROP, whereas 182 infants had no such treatment. BW and the NLR were significantly associated with ROP treatment (OR: 1.6 and 0.66,
p
< 0.001 and 0.003, respectively).
Conclusion
The NLR was not a risk factor for ROP development but was a risk factor for ROP treatment.</description><subject>Adrenal Cortex Hormones</subject><subject>Birth Weight</subject><subject>Chorioamnionitis</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Very Low Birth Weight</subject><subject>Infants</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neutrophils</subject><subject>Ophthalmology</subject><subject>Retinal Disorders</subject><subject>Retinopathy</subject><subject>Retinopathy of Prematurity - diagnosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Steroids</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctKxTAQhoMoery8gAsJuHETza1Ns1TxBoIbBXchplNPtW1qki769kaPF3DhbGbIfPNnmB-hfUaPGaXqJFIqmSKUc0ILTTmRa2jBpCiIovxxHS2o4oxUgj9uoe0YX2jmRcE20ZYohaqE0AtkzzrvazzAlIIfl21Hkifd3I9L7-YEONjUemwjtji08RU31iUfcDvgFMCmHoaEm_wQILWDH21aztg3eAzQ2zSFNs27aKOxXYS9r7yDHi4v7s-vye3d1c356S1xsioScZUrALiwtGi4ErKWtuS1UywXwCvOaMOZBq2YK-uqsLq02kmhnHWUMlaLHXS00h2Df5sgJtO30UHX2QH8FE0WLXPIkmX08A_64qcw5O0ypZmqmC50pviKcsHHGKAxY2h7G2bDqPkwwKwMMNkA82mAkXno4Et6euqh_hn5vngGxAqIuTU8Q_j9-x_Zd79IkYo</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Obata, Shumpei</creator><creator>Matsumoto, Riko</creator><creator>Kakinoki, Masashi</creator><creator>Sawada, Osamu</creator><creator>Sawada, Tomoko</creator><creator>Saishin, Yoshitsugu</creator><creator>Yanagi, Takahide</creator><creator>Maruo, Yoshihiro</creator><creator>Ohji, Masahito</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6120-2392</orcidid></search><sort><creationdate>20230401</creationdate><title>Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity</title><author>Obata, Shumpei ; Matsumoto, Riko ; Kakinoki, Masashi ; Sawada, Osamu ; Sawada, Tomoko ; Saishin, Yoshitsugu ; Yanagi, Takahide ; Maruo, Yoshihiro ; Ohji, Masahito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-c8c5ee23a05f2734d4a62dc71d4ae28210f219e971c6d85a96a9c437cac0011d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adrenal Cortex Hormones</topic><topic>Birth Weight</topic><topic>Chorioamnionitis</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neutrophils</topic><topic>Ophthalmology</topic><topic>Retinal Disorders</topic><topic>Retinopathy</topic><topic>Retinopathy of Prematurity - diagnosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obata, Shumpei</creatorcontrib><creatorcontrib>Matsumoto, Riko</creatorcontrib><creatorcontrib>Kakinoki, Masashi</creatorcontrib><creatorcontrib>Sawada, Osamu</creatorcontrib><creatorcontrib>Sawada, Tomoko</creatorcontrib><creatorcontrib>Saishin, Yoshitsugu</creatorcontrib><creatorcontrib>Yanagi, Takahide</creatorcontrib><creatorcontrib>Maruo, Yoshihiro</creatorcontrib><creatorcontrib>Ohji, Masahito</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obata, Shumpei</au><au>Matsumoto, Riko</au><au>Kakinoki, Masashi</au><au>Sawada, Osamu</au><au>Sawada, Tomoko</au><au>Saishin, Yoshitsugu</au><au>Yanagi, Takahide</au><au>Maruo, Yoshihiro</au><au>Ohji, Masahito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>261</volume><issue>4</issue><spage>951</spage><epage>957</epage><pages>951-957</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To investigate the blood neutrophil-to-lymphocyte ratio (NLR) as a risk factor for retinopathy of prematurity (ROP) development or treatment.
Methods
Retrospective cohort study. Infants who underwent ROP screening at Shiga University of Medical Science Hospital and Omihachiman Community Medical Center between April 2010 and December 2021 were included in this study. Screening criteria were gestational age (GA) < 32 weeks or birth weight (BW) < 1500 g. Multivariate logistic regression analysis was applied to investigate whether the NLR constituted an independent risk factor for ROP development or treatment. The objective variable was ROP development or treatment, and the explanatory variables were GA, BW, NLR, maternal infection or clinical chorioamnionitis and corticosteroid use by the mother. Maternal infection or clinical chorioamnionitis and corticosteroid use by the mother was included in the explanatory variables to adjust for factors affecting the NLR.
Results
In total, 220 infants met the inclusion criteria, of whom 125 developed ROP, whereas 95 infants did not display ROP. GA was significantly associated with ROP development (odds ratio (OR): 0.41,
p
< 0.001); however, the NLR was not significantly associated with ROP development (OR: 1.0,
p
= 0.74). Thirty-eight infants received treatment for ROP, whereas 182 infants had no such treatment. BW and the NLR were significantly associated with ROP treatment (OR: 1.6 and 0.66,
p
< 0.001 and 0.003, respectively).
Conclusion
The NLR was not a risk factor for ROP development but was a risk factor for ROP treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36378339</pmid><doi>10.1007/s00417-022-05902-4</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6120-2392</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2023-04, Vol.261 (4), p.951-957 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adrenal Cortex Hormones Birth Weight Chorioamnionitis Female Gestational Age Humans Incidence Infant Infant, Newborn Infant, Very Low Birth Weight Infants Leukocytes (neutrophilic) Lymphocytes Medicine Medicine & Public Health Neutrophils Ophthalmology Retinal Disorders Retinopathy Retinopathy of Prematurity - diagnosis Retrospective Studies Risk Factors Steroids |
| title | Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity |
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