A New Highly Oxygenated Polyketide Derivative from Trichoderma sp. and Its Antifungal Activity
A new highly oxygenated polyketide derivative, trichodersine (1), together with fourteen known compounds (2‐15) were isolated from Trichoderma sp. MWTGP‐04. The structure of trichodersine (1) was established based on comprehensive spectroscopic data analysis, and biogenesis argument. The results of...
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| Veröffentlicht in: | Chemistry & biodiversity 2022-12, Vol.19 (12), p.e202200671-n/a |
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| creator | Wang, Cheng‐Yao Gan, Dong Li, Chen‐Zhe Zhang, Sheng‐Qi Li, Bin‐Xian Zhu, Li Liu, Jia‐Qi Liu, Han Tuo, Gui‐Tao Zhang, Feng‐Mei Cai, Le |
| description | A new highly oxygenated polyketide derivative, trichodersine (1), together with fourteen known compounds (2‐15) were isolated from Trichoderma sp. MWTGP‐04. The structure of trichodersine (1) was established based on comprehensive spectroscopic data analysis, and biogenesis argument. The results of double culture experiments indicated that the strain exhibited potential antifungal activity. The antifungal activities of all isolated compounds were evaluated, among them compound 1 exhibited remarkable antifungal activities against Fusarium solani, Plectosphaerella cucumerina, Alternaria panax, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 4, 4, 16, and 32 μg/mL, respectively. In addition, the antifungal experiments of polyketide derivatives (1–3) disclosed that their degree of oxidation was a key factor affecting the antifungal activity. |
| doi_str_mv | 10.1002/cbdv.202200671 |
| format | Article |
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MWTGP‐04. The structure of trichodersine (1) was established based on comprehensive spectroscopic data analysis, and biogenesis argument. The results of double culture experiments indicated that the strain exhibited potential antifungal activity. The antifungal activities of all isolated compounds were evaluated, among them compound 1 exhibited remarkable antifungal activities against Fusarium solani, Plectosphaerella cucumerina, Alternaria panax, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 4, 4, 16, and 32 μg/mL, respectively. In addition, the antifungal experiments of polyketide derivatives (1–3) disclosed that their degree of oxidation was a key factor affecting the antifungal activity.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202200671</identifier><identifier>PMID: 36373236</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Antifungal activity ; Antifungal Agents - chemistry ; Aspergillus niger ; Data analysis ; Fungi ; Fungicides ; highly oxygenated polyketide derivative ; Microbial Sensitivity Tests ; Oxidation ; Oxygenation ; Polyketides - pharmacology ; Trichoderma ; Trichoderma - chemistry ; Trichoderma sp</subject><ispartof>Chemistry & biodiversity, 2022-12, Vol.19 (12), p.e202200671-n/a</ispartof><rights>2022 Wiley‐VHCA AG, Zurich, Switzerland</rights><rights>2022 Wiley-VHCA AG, Zurich, Switzerland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3731-974d1d7eadb3b10ab4748204ee53a6a15b41d863528cd30dae2cee020cd8ce4f3</citedby><cites>FETCH-LOGICAL-c3731-974d1d7eadb3b10ab4748204ee53a6a15b41d863528cd30dae2cee020cd8ce4f3</cites><orcidid>0000-0003-0970-4920</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202200671$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202200671$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36373236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Cheng‐Yao</creatorcontrib><creatorcontrib>Gan, Dong</creatorcontrib><creatorcontrib>Li, Chen‐Zhe</creatorcontrib><creatorcontrib>Zhang, Sheng‐Qi</creatorcontrib><creatorcontrib>Li, Bin‐Xian</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Liu, Jia‐Qi</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Tuo, Gui‐Tao</creatorcontrib><creatorcontrib>Zhang, Feng‐Mei</creatorcontrib><creatorcontrib>Cai, Le</creatorcontrib><title>A New Highly Oxygenated Polyketide Derivative from Trichoderma sp. and Its Antifungal Activity</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>A new highly oxygenated polyketide derivative, trichodersine (1), together with fourteen known compounds (2‐15) were isolated from Trichoderma sp. MWTGP‐04. The structure of trichodersine (1) was established based on comprehensive spectroscopic data analysis, and biogenesis argument. The results of double culture experiments indicated that the strain exhibited potential antifungal activity. The antifungal activities of all isolated compounds were evaluated, among them compound 1 exhibited remarkable antifungal activities against Fusarium solani, Plectosphaerella cucumerina, Alternaria panax, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 4, 4, 16, and 32 μg/mL, respectively. In addition, the antifungal experiments of polyketide derivatives (1–3) disclosed that their degree of oxidation was a key factor affecting the antifungal activity.</description><subject>Antifungal activity</subject><subject>Antifungal Agents - chemistry</subject><subject>Aspergillus niger</subject><subject>Data analysis</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>highly oxygenated polyketide derivative</subject><subject>Microbial Sensitivity Tests</subject><subject>Oxidation</subject><subject>Oxygenation</subject><subject>Polyketides - pharmacology</subject><subject>Trichoderma</subject><subject>Trichoderma - chemistry</subject><subject>Trichoderma sp</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtPAjEUBeDGaETRrUvTxI0bsK95uER8QELEBbp00mnvQHUe2M6g8-8tATFx46pN8_Xk3oPQGSV9Sgi7Uqle9RlhjJAwonvoiIaU9Wgck_3dPWIddOzcm_f-PT5EHR7yiDMeHqHXAX6ETzwy80Xe4ulXO4dS1qDxU5W371AbDfgWrFnJ2qwAZ7Yq8Mwatag02EJit-xjWWo8rh0elLXJmnIuczxQnpu6PUEHmcwdnG7PLnq-v5sNR73J9GE8HEx6yg9Ce9eR0FRHIHXKU0pkKiIRMyIAAi5DSYNUUB2HPGCx0pxoCUwBEEaUjhWIjHfR5SZ3aauPBlydFMYpyHNZQtW4hEV-ZRIIEnt68Ye-VY0t_XReBRELRCCEV_2NUrZyzkKWLK0ppG0TSpJ188m6-WTXvP9wvo1t0gL0jv9U7cH1BnyaHNp_4pLhze3Lb_g3RBKPOQ</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Wang, Cheng‐Yao</creator><creator>Gan, Dong</creator><creator>Li, Chen‐Zhe</creator><creator>Zhang, Sheng‐Qi</creator><creator>Li, Bin‐Xian</creator><creator>Zhu, Li</creator><creator>Liu, Jia‐Qi</creator><creator>Liu, Han</creator><creator>Tuo, Gui‐Tao</creator><creator>Zhang, Feng‐Mei</creator><creator>Cai, Le</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0970-4920</orcidid></search><sort><creationdate>202212</creationdate><title>A New Highly Oxygenated Polyketide Derivative from Trichoderma sp. and Its Antifungal Activity</title><author>Wang, Cheng‐Yao ; Gan, Dong ; Li, Chen‐Zhe ; Zhang, Sheng‐Qi ; Li, Bin‐Xian ; Zhu, Li ; Liu, Jia‐Qi ; Liu, Han ; Tuo, Gui‐Tao ; Zhang, Feng‐Mei ; Cai, Le</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3731-974d1d7eadb3b10ab4748204ee53a6a15b41d863528cd30dae2cee020cd8ce4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antifungal activity</topic><topic>Antifungal Agents - chemistry</topic><topic>Aspergillus niger</topic><topic>Data analysis</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>highly oxygenated polyketide derivative</topic><topic>Microbial Sensitivity Tests</topic><topic>Oxidation</topic><topic>Oxygenation</topic><topic>Polyketides - pharmacology</topic><topic>Trichoderma</topic><topic>Trichoderma - chemistry</topic><topic>Trichoderma sp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Cheng‐Yao</creatorcontrib><creatorcontrib>Gan, Dong</creatorcontrib><creatorcontrib>Li, Chen‐Zhe</creatorcontrib><creatorcontrib>Zhang, Sheng‐Qi</creatorcontrib><creatorcontrib>Li, Bin‐Xian</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Liu, Jia‐Qi</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Tuo, Gui‐Tao</creatorcontrib><creatorcontrib>Zhang, Feng‐Mei</creatorcontrib><creatorcontrib>Cai, Le</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Cheng‐Yao</au><au>Gan, Dong</au><au>Li, Chen‐Zhe</au><au>Zhang, Sheng‐Qi</au><au>Li, Bin‐Xian</au><au>Zhu, Li</au><au>Liu, Jia‐Qi</au><au>Liu, Han</au><au>Tuo, Gui‐Tao</au><au>Zhang, Feng‐Mei</au><au>Cai, Le</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Highly Oxygenated Polyketide Derivative from Trichoderma sp. and Its Antifungal Activity</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2022-12</date><risdate>2022</risdate><volume>19</volume><issue>12</issue><spage>e202200671</spage><epage>n/a</epage><pages>e202200671-n/a</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>A new highly oxygenated polyketide derivative, trichodersine (1), together with fourteen known compounds (2‐15) were isolated from Trichoderma sp. MWTGP‐04. The structure of trichodersine (1) was established based on comprehensive spectroscopic data analysis, and biogenesis argument. The results of double culture experiments indicated that the strain exhibited potential antifungal activity. The antifungal activities of all isolated compounds were evaluated, among them compound 1 exhibited remarkable antifungal activities against Fusarium solani, Plectosphaerella cucumerina, Alternaria panax, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 4, 4, 16, and 32 μg/mL, respectively. In addition, the antifungal experiments of polyketide derivatives (1–3) disclosed that their degree of oxidation was a key factor affecting the antifungal activity.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36373236</pmid><doi>10.1002/cbdv.202200671</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0970-4920</orcidid></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | Antifungal activity Antifungal Agents - chemistry Aspergillus niger Data analysis Fungi Fungicides highly oxygenated polyketide derivative Microbial Sensitivity Tests Oxidation Oxygenation Polyketides - pharmacology Trichoderma Trichoderma - chemistry Trichoderma sp |
| title | A New Highly Oxygenated Polyketide Derivative from Trichoderma sp. and Its Antifungal Activity |
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