The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics
Background Nasal adhesions (NAs) are a known complication of nasal airway surgery. Even minor NAs can lead to significant postoperative nasal airway obstruction (NAO). Division of such NAs often provides much greater relief than anticipated. Objective We examine the impact of NAs at various anatomic...
Gespeichert in:
| Veröffentlicht in: | American journal of rhinology & allergy 2023-05, Vol.37 (3), p.273-283 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 283 |
|---|---|
| container_issue | 3 |
| container_start_page | 273 |
| container_title | American journal of rhinology & allergy |
| container_volume | 37 |
| creator | Senanayake, Praween Warfield-McAlpine, Patrick Salati, Hana Bradshaw, Kimberley Wong, Eugene Inthavong, Kiao Singh, Narinder |
| description | Background
Nasal adhesions (NAs) are a known complication of nasal airway surgery. Even minor NAs can lead to significant postoperative nasal airway obstruction (NAO). Division of such NAs often provides much greater relief than anticipated.
Objective
We examine the impact of NAs at various anatomical sites on nasal airflow and mucosal cooling using computational fluid dynamics (CFD) and multiple test subjects.
Methods
CT scans of healthy adult subjects were used to construct three-dimensional nasal airway computational models. A single virtual 2.5 mm diameter NA was placed at one of five sites commonly seen following NAO surgery within each nasal cavity bilaterally, resulting in 10 NA models and 1 NA-free control for each subject. CFD analysis was performed on each NA model and compared with the subject's NA-free control model.
Results
4 subjects were recruited to create 44 computational models. The NAs caused the airflow streamlines to separate, leading to a statistically significant increase in mucosal temperature immediately downstream to the NAs (wake region). Changes in the mucosal temperature in the wake region of the NAs were most prominent in anteriorly located NAs with a mean increase of 1.62 °C for the anterior inferior turbinate NAs (P |
| doi_str_mv | 10.1177/19458924221137982 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2736305234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_19458924221137982</sage_id><sourcerecordid>2736305234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-81a1d1974b46810a0162ff1269cc18fd3a1766629f0e562242f406c93fc2ca133</originalsourceid><addsrcrecordid>eNp9kM1OwzAQhC0Eovw9ABfkI5eC13bshFtUKCBVIKT2HLmODUZJXLIJqG9PqhYuSJx2tfvNSDOEnAO7AtD6GjKZpBmXnAMInaV8jxxtbuM0E3z_d-dyRI4R3xlTMpFwSEZCCS0SrY9IOX9z9LFeGdvR6GlevjkMsUEaG_pk0FQ0D62v4tcNzelLb5oudKYLn47mjanWGJAuMDSvdBLrVb95xeFOp1UfSnq7bkwdLJ6SA28qdGe7eUIW07v55GE8e75_nOSzsRWSdeMUDJSQabmUKgVmGCjuPXCVWQupL4UBrZTimWcuUXzI7SVTNhPecmtAiBNyufVdtfGjd9gVdUDrqso0LvZYcD0EZwkXckBhi9o2IrbOF6s21KZdF8CKTbnFn3IHzcXOvl_WrvxV_LQ5AFdbAM2rK95j3w5d4D-O30f5gGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2736305234</pqid></control><display><type>article</type><title>The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics</title><source>MEDLINE</source><source>SAGE Journals</source><source>Alma/SFX Local Collection</source><creator>Senanayake, Praween ; Warfield-McAlpine, Patrick ; Salati, Hana ; Bradshaw, Kimberley ; Wong, Eugene ; Inthavong, Kiao ; Singh, Narinder</creator><creatorcontrib>Senanayake, Praween ; Warfield-McAlpine, Patrick ; Salati, Hana ; Bradshaw, Kimberley ; Wong, Eugene ; Inthavong, Kiao ; Singh, Narinder</creatorcontrib><description>Background
Nasal adhesions (NAs) are a known complication of nasal airway surgery. Even minor NAs can lead to significant postoperative nasal airway obstruction (NAO). Division of such NAs often provides much greater relief than anticipated.
Objective
We examine the impact of NAs at various anatomical sites on nasal airflow and mucosal cooling using computational fluid dynamics (CFD) and multiple test subjects.
Methods
CT scans of healthy adult subjects were used to construct three-dimensional nasal airway computational models. A single virtual 2.5 mm diameter NA was placed at one of five sites commonly seen following NAO surgery within each nasal cavity bilaterally, resulting in 10 NA models and 1 NA-free control for each subject. CFD analysis was performed on each NA model and compared with the subject's NA-free control model.
Results
4 subjects were recruited to create 44 computational models. The NAs caused the airflow streamlines to separate, leading to a statistically significant increase in mucosal temperature immediately downstream to the NAs (wake region). Changes in the mucosal temperature in the wake region of the NAs were most prominent in anteriorly located NAs with a mean increase of 1.62 °C for the anterior inferior turbinate NAs (P < .001) and 0.63 °C for the internal valve NAs (P < .001).
Conclusion
NAs result in marked disruption to airflow patterns and reduced mucosal cooling on critical surfaces, particularly in the wake region. Reduced wake region mucosal cooling may be a contributing factor to the exaggerated perception of nasal obstruction experienced by patients with NAs.</description><identifier>ISSN: 1945-8924</identifier><identifier>EISSN: 1945-8932</identifier><identifier>DOI: 10.1177/19458924221137982</identifier><identifier>PMID: 36373577</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Computer Simulation ; Humans ; Hydrodynamics ; Nasal Cavity - diagnostic imaging ; Nasal Obstruction - surgery ; Nasopharynx ; Turbinates - surgery</subject><ispartof>American journal of rhinology & allergy, 2023-05, Vol.37 (3), p.273-283</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-81a1d1974b46810a0162ff1269cc18fd3a1766629f0e562242f406c93fc2ca133</citedby><cites>FETCH-LOGICAL-c340t-81a1d1974b46810a0162ff1269cc18fd3a1766629f0e562242f406c93fc2ca133</cites><orcidid>0000-0002-5799-5083 ; 0000-0003-0476-0237</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/19458924221137982$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/19458924221137982$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36373577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Senanayake, Praween</creatorcontrib><creatorcontrib>Warfield-McAlpine, Patrick</creatorcontrib><creatorcontrib>Salati, Hana</creatorcontrib><creatorcontrib>Bradshaw, Kimberley</creatorcontrib><creatorcontrib>Wong, Eugene</creatorcontrib><creatorcontrib>Inthavong, Kiao</creatorcontrib><creatorcontrib>Singh, Narinder</creatorcontrib><title>The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics</title><title>American journal of rhinology & allergy</title><addtitle>American Journal of Rhinology & Allergy</addtitle><description>Background
Nasal adhesions (NAs) are a known complication of nasal airway surgery. Even minor NAs can lead to significant postoperative nasal airway obstruction (NAO). Division of such NAs often provides much greater relief than anticipated.
Objective
We examine the impact of NAs at various anatomical sites on nasal airflow and mucosal cooling using computational fluid dynamics (CFD) and multiple test subjects.
Methods
CT scans of healthy adult subjects were used to construct three-dimensional nasal airway computational models. A single virtual 2.5 mm diameter NA was placed at one of five sites commonly seen following NAO surgery within each nasal cavity bilaterally, resulting in 10 NA models and 1 NA-free control for each subject. CFD analysis was performed on each NA model and compared with the subject's NA-free control model.
Results
4 subjects were recruited to create 44 computational models. The NAs caused the airflow streamlines to separate, leading to a statistically significant increase in mucosal temperature immediately downstream to the NAs (wake region). Changes in the mucosal temperature in the wake region of the NAs were most prominent in anteriorly located NAs with a mean increase of 1.62 °C for the anterior inferior turbinate NAs (P < .001) and 0.63 °C for the internal valve NAs (P < .001).
Conclusion
NAs result in marked disruption to airflow patterns and reduced mucosal cooling on critical surfaces, particularly in the wake region. Reduced wake region mucosal cooling may be a contributing factor to the exaggerated perception of nasal obstruction experienced by patients with NAs.</description><subject>Adult</subject><subject>Computer Simulation</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Nasal Cavity - diagnostic imaging</subject><subject>Nasal Obstruction - surgery</subject><subject>Nasopharynx</subject><subject>Turbinates - surgery</subject><issn>1945-8924</issn><issn>1945-8932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0Eovw9ABfkI5eC13bshFtUKCBVIKT2HLmODUZJXLIJqG9PqhYuSJx2tfvNSDOEnAO7AtD6GjKZpBmXnAMInaV8jxxtbuM0E3z_d-dyRI4R3xlTMpFwSEZCCS0SrY9IOX9z9LFeGdvR6GlevjkMsUEaG_pk0FQ0D62v4tcNzelLb5oudKYLn47mjanWGJAuMDSvdBLrVb95xeFOp1UfSnq7bkwdLJ6SA28qdGe7eUIW07v55GE8e75_nOSzsRWSdeMUDJSQabmUKgVmGCjuPXCVWQupL4UBrZTimWcuUXzI7SVTNhPecmtAiBNyufVdtfGjd9gVdUDrqso0LvZYcD0EZwkXckBhi9o2IrbOF6s21KZdF8CKTbnFn3IHzcXOvl_WrvxV_LQ5AFdbAM2rK95j3w5d4D-O30f5gGg</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Senanayake, Praween</creator><creator>Warfield-McAlpine, Patrick</creator><creator>Salati, Hana</creator><creator>Bradshaw, Kimberley</creator><creator>Wong, Eugene</creator><creator>Inthavong, Kiao</creator><creator>Singh, Narinder</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5799-5083</orcidid><orcidid>https://orcid.org/0000-0003-0476-0237</orcidid></search><sort><creationdate>202305</creationdate><title>The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics</title><author>Senanayake, Praween ; Warfield-McAlpine, Patrick ; Salati, Hana ; Bradshaw, Kimberley ; Wong, Eugene ; Inthavong, Kiao ; Singh, Narinder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-81a1d1974b46810a0162ff1269cc18fd3a1766629f0e562242f406c93fc2ca133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Computer Simulation</topic><topic>Humans</topic><topic>Hydrodynamics</topic><topic>Nasal Cavity - diagnostic imaging</topic><topic>Nasal Obstruction - surgery</topic><topic>Nasopharynx</topic><topic>Turbinates - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senanayake, Praween</creatorcontrib><creatorcontrib>Warfield-McAlpine, Patrick</creatorcontrib><creatorcontrib>Salati, Hana</creatorcontrib><creatorcontrib>Bradshaw, Kimberley</creatorcontrib><creatorcontrib>Wong, Eugene</creatorcontrib><creatorcontrib>Inthavong, Kiao</creatorcontrib><creatorcontrib>Singh, Narinder</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of rhinology & allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senanayake, Praween</au><au>Warfield-McAlpine, Patrick</au><au>Salati, Hana</au><au>Bradshaw, Kimberley</au><au>Wong, Eugene</au><au>Inthavong, Kiao</au><au>Singh, Narinder</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics</atitle><jtitle>American journal of rhinology & allergy</jtitle><addtitle>American Journal of Rhinology & Allergy</addtitle><date>2023-05</date><risdate>2023</risdate><volume>37</volume><issue>3</issue><spage>273</spage><epage>283</epage><pages>273-283</pages><issn>1945-8924</issn><eissn>1945-8932</eissn><abstract>Background
Nasal adhesions (NAs) are a known complication of nasal airway surgery. Even minor NAs can lead to significant postoperative nasal airway obstruction (NAO). Division of such NAs often provides much greater relief than anticipated.
Objective
We examine the impact of NAs at various anatomical sites on nasal airflow and mucosal cooling using computational fluid dynamics (CFD) and multiple test subjects.
Methods
CT scans of healthy adult subjects were used to construct three-dimensional nasal airway computational models. A single virtual 2.5 mm diameter NA was placed at one of five sites commonly seen following NAO surgery within each nasal cavity bilaterally, resulting in 10 NA models and 1 NA-free control for each subject. CFD analysis was performed on each NA model and compared with the subject's NA-free control model.
Results
4 subjects were recruited to create 44 computational models. The NAs caused the airflow streamlines to separate, leading to a statistically significant increase in mucosal temperature immediately downstream to the NAs (wake region). Changes in the mucosal temperature in the wake region of the NAs were most prominent in anteriorly located NAs with a mean increase of 1.62 °C for the anterior inferior turbinate NAs (P < .001) and 0.63 °C for the internal valve NAs (P < .001).
Conclusion
NAs result in marked disruption to airflow patterns and reduced mucosal cooling on critical surfaces, particularly in the wake region. Reduced wake region mucosal cooling may be a contributing factor to the exaggerated perception of nasal obstruction experienced by patients with NAs.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>36373577</pmid><doi>10.1177/19458924221137982</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5799-5083</orcidid><orcidid>https://orcid.org/0000-0003-0476-0237</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1945-8924 |
| ispartof | American journal of rhinology & allergy, 2023-05, Vol.37 (3), p.273-283 |
| issn | 1945-8924 1945-8932 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2736305234 |
| source | MEDLINE; SAGE Journals; Alma/SFX Local Collection |
| subjects | Adult Computer Simulation Humans Hydrodynamics Nasal Cavity - diagnostic imaging Nasal Obstruction - surgery Nasopharynx Turbinates - surgery |
| title | The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A05%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Impact%20of%20Adhesions%20on%20Nasal%20Airflow:%20A%20Quantitative%20Analysis%20Using%20Computational%20Fluid%20Dynamics&rft.jtitle=American%20journal%20of%20rhinology%20&%20allergy&rft.au=Senanayake,%20Praween&rft.date=2023-05&rft.volume=37&rft.issue=3&rft.spage=273&rft.epage=283&rft.pages=273-283&rft.issn=1945-8924&rft.eissn=1945-8932&rft_id=info:doi/10.1177/19458924221137982&rft_dat=%3Cproquest_cross%3E2736305234%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2736305234&rft_id=info:pmid/36373577&rft_sage_id=10.1177_19458924221137982&rfr_iscdi=true |