Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease?
Purpose Renin-angiotensin system (RAS) hyperactivity is a common entity in both autosomal dominant polycystic kidney disease (ADPKD) and obstructive sleep apnea (OSA). We aimed to investigate the frequency of OSA in adults with ADPKD either with stages 3–4 or stages 1–2 chronic kidney disease (CKD)...
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| Veröffentlicht in: | Sleep & breathing 2023-08, Vol.27 (4), p.1359-1363 |
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| creator | Yalin, Serkan Feyyaz Atahan, Ersan Gundogdu, Sule Parmaksiz, Ergun Mese, Meral Trabulus, Sinan Mutlu, Birsen Altiparmak, Mehmet Riza |
| description | Purpose
Renin-angiotensin system (RAS) hyperactivity is a common entity in both autosomal dominant polycystic kidney disease (ADPKD) and obstructive sleep apnea (OSA). We aimed to investigate the frequency of OSA in adults with ADPKD either with stages 3–4 or stages 1–2 chronic kidney disease (CKD) and evaluate the effect of RAS blockade on OSA in these patients.
Methods
This is a comparative, prospective, two-center clinical study. Eligible patients with ADPKD were enrolled in a polysomnography (PSG) study. Presence of OSA in patients with ADPKD was compared with individuals who underwent polisomnography study due to OSA symptoms. A subgroup analysis was performed in terms of the presence of OSA in ADPKD with eGFR values lower or higher than 60 ml/min/1.73 m
2
(stages 3–4 and stages 1–2 CKD, respectively).
Results
Frequency of OSA (65%) was higher than in the general population and similar between the two groups (
p
= 0.367). Patients with ADPKD and eGFR ≥ 60 ml/min/1.73 m
2
presented a similar frequency of OSA to the control group (
p
= 0.759). However, OSA was significantly more frequent in ADPKD with eGFR |
| doi_str_mv | 10.1007/s11325-022-02742-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2736304829</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2850916374</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-f565c24cd95a6a2c69732c3a90a80241c5c92efb27758b1293f1cd291dccc54c3</originalsourceid><addsrcrecordid>eNp9kcGK1TAUhoMozszVF3AhATduqknatI0bGQZHhQFBdB1yT0_HjG1Sc1Klb-Ljmjt3VHDhIiSHfP9_kvMz9kSKF1KI7iVJWStdCaXK6hpV9ffYqdSllJ0w92_PojJaqhN2RnQjhGx6Ix-yk7qtO9VLfcp-fsTgQ-XCtY8ZA_nAaaOMM3eQ_XeXfQyv-Ow27jP3ARI6Qj4m_LZigI3Hkcc95bQeaOQ0IS7cLQFdoflS9Bgy8R8-f-FuzZHi7CY-xNkHFzJf4rRB6eeBf_VDwI0Png4tXj9iD0Y3ET6-23fs8-WbTxfvqqsPb99fnF9VUKs2V6NuNagGBqNd6xS0pqsV1M4I1wvVSNBgFI571XW630tl6lHCoIwcAEA3UO_Y86PvkmL5E2U7ewKcJhcwrmRVV4Ylmr4od-zZP-hNXFMor7Oq18LIMtWmUOpIQYpECUe7JD-7tFkp7CE3e8zNltzsbW62L6Knd9brfsbhj-R3UAWojwCVq3CN6W_v_9j-AqtXpoM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2850916374</pqid></control><display><type>article</type><title>Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease?</title><source>Springer Nature - Complete Springer Journals</source><creator>Yalin, Serkan Feyyaz ; Atahan, Ersan ; Gundogdu, Sule ; Parmaksiz, Ergun ; Mese, Meral ; Trabulus, Sinan ; Mutlu, Birsen ; Altiparmak, Mehmet Riza</creator><creatorcontrib>Yalin, Serkan Feyyaz ; Atahan, Ersan ; Gundogdu, Sule ; Parmaksiz, Ergun ; Mese, Meral ; Trabulus, Sinan ; Mutlu, Birsen ; Altiparmak, Mehmet Riza</creatorcontrib><description>Purpose
Renin-angiotensin system (RAS) hyperactivity is a common entity in both autosomal dominant polycystic kidney disease (ADPKD) and obstructive sleep apnea (OSA). We aimed to investigate the frequency of OSA in adults with ADPKD either with stages 3–4 or stages 1–2 chronic kidney disease (CKD) and evaluate the effect of RAS blockade on OSA in these patients.
Methods
This is a comparative, prospective, two-center clinical study. Eligible patients with ADPKD were enrolled in a polysomnography (PSG) study. Presence of OSA in patients with ADPKD was compared with individuals who underwent polisomnography study due to OSA symptoms. A subgroup analysis was performed in terms of the presence of OSA in ADPKD with eGFR values lower or higher than 60 ml/min/1.73 m
2
(stages 3–4 and stages 1–2 CKD, respectively).
Results
Frequency of OSA (65%) was higher than in the general population and similar between the two groups (
p
= 0.367). Patients with ADPKD and eGFR ≥ 60 ml/min/1.73 m
2
presented a similar frequency of OSA to the control group (
p
= 0.759). However, OSA was significantly more frequent in ADPKD with eGFR < 60 ml/min/1.73 m
2
(
p
= 0.018). Subgroup analysis revealed that presence of OSA also was significantly higher in ADPKD with lower eGFR levels (eGFR < 60 ml/min/1.73 m
2
and eGFR > 60 ml/min/1.73 m
2
) 14/17 (82%) and 12/23 (52%), respectively (
p
: 0.048).
Conclusion
As kidney disease progresses, uremia and related factors of renal failure rather than RAS activation seem to play a more important role for the development of OSA in patients with ADPKD.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-022-02742-8</identifier><identifier>PMID: 36372815</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Angiotensin ; Apnea ; Dentistry ; Endocrine system ; Epidermal growth factor receptors ; Hyperactivity ; Internal Medicine ; Kidney diseases ; Medicine ; Medicine & Public Health ; Neurology ; Otorhinolaryngology ; Pediatrics ; Pneumology/Respiratory System ; Polycystic kidney ; Renal failure ; Renin ; Sleep apnea ; Sleep Breathing Physiology and Disorders • Original Article ; Sleep disorders ; Uremia</subject><ispartof>Sleep & breathing, 2023-08, Vol.27 (4), p.1359-1363</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-f565c24cd95a6a2c69732c3a90a80241c5c92efb27758b1293f1cd291dccc54c3</cites><orcidid>0000-0002-8146-6966</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-022-02742-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-022-02742-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36372815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yalin, Serkan Feyyaz</creatorcontrib><creatorcontrib>Atahan, Ersan</creatorcontrib><creatorcontrib>Gundogdu, Sule</creatorcontrib><creatorcontrib>Parmaksiz, Ergun</creatorcontrib><creatorcontrib>Mese, Meral</creatorcontrib><creatorcontrib>Trabulus, Sinan</creatorcontrib><creatorcontrib>Mutlu, Birsen</creatorcontrib><creatorcontrib>Altiparmak, Mehmet Riza</creatorcontrib><title>Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease?</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
Renin-angiotensin system (RAS) hyperactivity is a common entity in both autosomal dominant polycystic kidney disease (ADPKD) and obstructive sleep apnea (OSA). We aimed to investigate the frequency of OSA in adults with ADPKD either with stages 3–4 or stages 1–2 chronic kidney disease (CKD) and evaluate the effect of RAS blockade on OSA in these patients.
Methods
This is a comparative, prospective, two-center clinical study. Eligible patients with ADPKD were enrolled in a polysomnography (PSG) study. Presence of OSA in patients with ADPKD was compared with individuals who underwent polisomnography study due to OSA symptoms. A subgroup analysis was performed in terms of the presence of OSA in ADPKD with eGFR values lower or higher than 60 ml/min/1.73 m
2
(stages 3–4 and stages 1–2 CKD, respectively).
Results
Frequency of OSA (65%) was higher than in the general population and similar between the two groups (
p
= 0.367). Patients with ADPKD and eGFR ≥ 60 ml/min/1.73 m
2
presented a similar frequency of OSA to the control group (
p
= 0.759). However, OSA was significantly more frequent in ADPKD with eGFR < 60 ml/min/1.73 m
2
(
p
= 0.018). Subgroup analysis revealed that presence of OSA also was significantly higher in ADPKD with lower eGFR levels (eGFR < 60 ml/min/1.73 m
2
and eGFR > 60 ml/min/1.73 m
2
) 14/17 (82%) and 12/23 (52%), respectively (
p
: 0.048).
Conclusion
As kidney disease progresses, uremia and related factors of renal failure rather than RAS activation seem to play a more important role for the development of OSA in patients with ADPKD.</description><subject>Angiotensin</subject><subject>Apnea</subject><subject>Dentistry</subject><subject>Endocrine system</subject><subject>Epidermal growth factor receptors</subject><subject>Hyperactivity</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Polycystic kidney</subject><subject>Renal failure</subject><subject>Renin</subject><subject>Sleep apnea</subject><subject>Sleep Breathing Physiology and Disorders • Original Article</subject><subject>Sleep disorders</subject><subject>Uremia</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kcGK1TAUhoMozszVF3AhATduqknatI0bGQZHhQFBdB1yT0_HjG1Sc1Klb-Ljmjt3VHDhIiSHfP9_kvMz9kSKF1KI7iVJWStdCaXK6hpV9ffYqdSllJ0w92_PojJaqhN2RnQjhGx6Ix-yk7qtO9VLfcp-fsTgQ-XCtY8ZA_nAaaOMM3eQ_XeXfQyv-Ow27jP3ARI6Qj4m_LZigI3Hkcc95bQeaOQ0IS7cLQFdoflS9Bgy8R8-f-FuzZHi7CY-xNkHFzJf4rRB6eeBf_VDwI0Png4tXj9iD0Y3ET6-23fs8-WbTxfvqqsPb99fnF9VUKs2V6NuNagGBqNd6xS0pqsV1M4I1wvVSNBgFI571XW630tl6lHCoIwcAEA3UO_Y86PvkmL5E2U7ewKcJhcwrmRVV4Ylmr4od-zZP-hNXFMor7Oq18LIMtWmUOpIQYpECUe7JD-7tFkp7CE3e8zNltzsbW62L6Knd9brfsbhj-R3UAWojwCVq3CN6W_v_9j-AqtXpoM</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Yalin, Serkan Feyyaz</creator><creator>Atahan, Ersan</creator><creator>Gundogdu, Sule</creator><creator>Parmaksiz, Ergun</creator><creator>Mese, Meral</creator><creator>Trabulus, Sinan</creator><creator>Mutlu, Birsen</creator><creator>Altiparmak, Mehmet Riza</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8146-6966</orcidid></search><sort><creationdate>20230801</creationdate><title>Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease?</title><author>Yalin, Serkan Feyyaz ; Atahan, Ersan ; Gundogdu, Sule ; Parmaksiz, Ergun ; Mese, Meral ; Trabulus, Sinan ; Mutlu, Birsen ; Altiparmak, Mehmet Riza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-f565c24cd95a6a2c69732c3a90a80241c5c92efb27758b1293f1cd291dccc54c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiotensin</topic><topic>Apnea</topic><topic>Dentistry</topic><topic>Endocrine system</topic><topic>Epidermal growth factor receptors</topic><topic>Hyperactivity</topic><topic>Internal Medicine</topic><topic>Kidney diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Polycystic kidney</topic><topic>Renal failure</topic><topic>Renin</topic><topic>Sleep apnea</topic><topic>Sleep Breathing Physiology and Disorders • Original Article</topic><topic>Sleep disorders</topic><topic>Uremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yalin, Serkan Feyyaz</creatorcontrib><creatorcontrib>Atahan, Ersan</creatorcontrib><creatorcontrib>Gundogdu, Sule</creatorcontrib><creatorcontrib>Parmaksiz, Ergun</creatorcontrib><creatorcontrib>Mese, Meral</creatorcontrib><creatorcontrib>Trabulus, Sinan</creatorcontrib><creatorcontrib>Mutlu, Birsen</creatorcontrib><creatorcontrib>Altiparmak, Mehmet Riza</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yalin, Serkan Feyyaz</au><au>Atahan, Ersan</au><au>Gundogdu, Sule</au><au>Parmaksiz, Ergun</au><au>Mese, Meral</au><au>Trabulus, Sinan</au><au>Mutlu, Birsen</au><au>Altiparmak, Mehmet Riza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease?</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>27</volume><issue>4</issue><spage>1359</spage><epage>1363</epage><pages>1359-1363</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
Renin-angiotensin system (RAS) hyperactivity is a common entity in both autosomal dominant polycystic kidney disease (ADPKD) and obstructive sleep apnea (OSA). We aimed to investigate the frequency of OSA in adults with ADPKD either with stages 3–4 or stages 1–2 chronic kidney disease (CKD) and evaluate the effect of RAS blockade on OSA in these patients.
Methods
This is a comparative, prospective, two-center clinical study. Eligible patients with ADPKD were enrolled in a polysomnography (PSG) study. Presence of OSA in patients with ADPKD was compared with individuals who underwent polisomnography study due to OSA symptoms. A subgroup analysis was performed in terms of the presence of OSA in ADPKD with eGFR values lower or higher than 60 ml/min/1.73 m
2
(stages 3–4 and stages 1–2 CKD, respectively).
Results
Frequency of OSA (65%) was higher than in the general population and similar between the two groups (
p
= 0.367). Patients with ADPKD and eGFR ≥ 60 ml/min/1.73 m
2
presented a similar frequency of OSA to the control group (
p
= 0.759). However, OSA was significantly more frequent in ADPKD with eGFR < 60 ml/min/1.73 m
2
(
p
= 0.018). Subgroup analysis revealed that presence of OSA also was significantly higher in ADPKD with lower eGFR levels (eGFR < 60 ml/min/1.73 m
2
and eGFR > 60 ml/min/1.73 m
2
) 14/17 (82%) and 12/23 (52%), respectively (
p
: 0.048).
Conclusion
As kidney disease progresses, uremia and related factors of renal failure rather than RAS activation seem to play a more important role for the development of OSA in patients with ADPKD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36372815</pmid><doi>10.1007/s11325-022-02742-8</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8146-6966</orcidid></addata></record> |
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| issn | 1520-9512 1522-1709 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Angiotensin Apnea Dentistry Endocrine system Epidermal growth factor receptors Hyperactivity Internal Medicine Kidney diseases Medicine Medicine & Public Health Neurology Otorhinolaryngology Pediatrics Pneumology/Respiratory System Polycystic kidney Renal failure Renin Sleep apnea Sleep Breathing Physiology and Disorders • Original Article Sleep disorders Uremia |
| title | Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease? |
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