Fucoidan-ferulic acid nanoparticles alleviate cisplatin-induced acute kidney injury by inhibiting the cGAS-STING pathway

Fucoidan (FU) is a natural sulfated polysaccharide with certain biological activity and has been shown to be an excellent nano-delivery material. In this study, ferulic acid (FA)-loaded FU nanoparticles (FA/FU NPs) were prepared and their nephroprotective mechanism was investigated. With a particle...

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Veröffentlicht in:	International journal of biological macromolecules 2022-12, Vol.223 (Pt A), p.1083-1093
Hauptverfasser:	Gao, Xintao, Wang, Jing, Wang, Yaqi, Liu, Shuai, Dong, Kehong, Wu, Jing, Wu, Xiaochen, Shi, Dayong, Wang, Fanye, Guo, Chuanlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Animals cGAS-STING Cisplatin - adverse effects Coumaric Acids - pharmacology Drug delivery Ferulic acid Fucoidan Humans Mice Nanoparticles Polysaccharides - adverse effects
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