Optic disc drusen in patients diagnosed with normal tension glaucoma
Purpose To investigate the prevalence of optic disc drusen (ODD) and optic nerve head (ONH) morphology in patients diagnosed with normal tension glaucoma (NTG). Methods In this prospective cross‐sectional study, we included patients diagnosed with NTG from two glaucoma units. In both eyes, dense enh...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2023-05, Vol.101 (3), p.277-284 |
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| creator | Ahmadi, Hamid Fotesko, Kyrylo Ba‐Ali, Shakoor Hamann, Steffen Kolko, Miriam |
| description | Purpose
To investigate the prevalence of optic disc drusen (ODD) and optic nerve head (ONH) morphology in patients diagnosed with normal tension glaucoma (NTG).
Methods
In this prospective cross‐sectional study, we included patients diagnosed with NTG from two glaucoma units. In both eyes, dense enhanced depth imaging optical coherence tomography volume scans of the ONH by means of standardized scanning guidelines were performed to examine for presence of ODD, and radial ONH scans were used for investigating parameters such as scleral canal diameter, cup/disc ratio and cup depth.
Results
We found ODD in 7 (3.6%) of 195 eyes, in 6 (6.1%) out of 98 patients diagnosed with NTG. The ODD were not ophthalmoscopically visible in five out of six patients. Eyes with ODD had lower cup/disc ratio, 0.44 ± 0.4 (p = 0.040), and less‐prominent cup depth, 236.6 ± 204.4 μm (p = 0.041) compared to eyes without ODD, 0.81 ± 0.2 and 437.8 ± 139.1 μm, respectively. We found no significant difference in scleral canal diameter between the eyes without (1602.8 ± 193 μm) and those with ODD (1492 ± 123.4 μm, p = 0.057).
Conclusion
The prevalence of ODD in patients diagnosed with NTG is substantially higher than in the background population. A low cup/disc ratio correlates with ODD presence. Therefore, due to the challenges associated with NTG diagnosis, we recommend examining the deep layers of the ONH in NTG patients with a cup/disc ratio lower than 0.5 to avoid misdiagnosing ODD as NTG. |
| doi_str_mv | 10.1111/aos.15286 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2736304060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2736304060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3486-6a7adef8d3c3f78e222dd50cc4ac485c248b9d2e283589bf357098878e37cb6c3</originalsourceid><addsrcrecordid>eNp10E1LwzAcBvAgipvTg19ACl700C1Nmpcex3yFwQ4qeAtpks6ONqlNy9i3N9q5g2AOSQg_Hv55ALhM4DQJayadnyYEcXoExgkjJMaM8uPDnbyPwJn3GwhpQml6CkaYYoY5ycbgbtV0pYp06cPW9t7YqLRRI7vS2M6Hd7m2zhsdbcvuI7KurWUVdcb60tloXcleuVqeg5NCVt5c7M8JeHu4f108xcvV4_NivowVTjmNqWRSm4JrrHDBuEEIaU2gUqlUKScKpTzPNDKIY8KzvMCEwYzzIDFTOVV4Am6G3KZ1n73xnajD3KaqpDWu9wKx8DGYQgoDvf5DN65vbZguqIyHcShGQd0OSrXO-9YUomnLWrY7kUDxXa0I1YqfaoO92if2eW30Qf52GcBsANuyMrv_k8R89TJEfgFNZYIW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2798486632</pqid></control><display><type>article</type><title>Optic disc drusen in patients diagnosed with normal tension glaucoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Ahmadi, Hamid ; Fotesko, Kyrylo ; Ba‐Ali, Shakoor ; Hamann, Steffen ; Kolko, Miriam</creator><creatorcontrib>Ahmadi, Hamid ; Fotesko, Kyrylo ; Ba‐Ali, Shakoor ; Hamann, Steffen ; Kolko, Miriam</creatorcontrib><description>Purpose
To investigate the prevalence of optic disc drusen (ODD) and optic nerve head (ONH) morphology in patients diagnosed with normal tension glaucoma (NTG).
Methods
In this prospective cross‐sectional study, we included patients diagnosed with NTG from two glaucoma units. In both eyes, dense enhanced depth imaging optical coherence tomography volume scans of the ONH by means of standardized scanning guidelines were performed to examine for presence of ODD, and radial ONH scans were used for investigating parameters such as scleral canal diameter, cup/disc ratio and cup depth.
Results
We found ODD in 7 (3.6%) of 195 eyes, in 6 (6.1%) out of 98 patients diagnosed with NTG. The ODD were not ophthalmoscopically visible in five out of six patients. Eyes with ODD had lower cup/disc ratio, 0.44 ± 0.4 (p = 0.040), and less‐prominent cup depth, 236.6 ± 204.4 μm (p = 0.041) compared to eyes without ODD, 0.81 ± 0.2 and 437.8 ± 139.1 μm, respectively. We found no significant difference in scleral canal diameter between the eyes without (1602.8 ± 193 μm) and those with ODD (1492 ± 123.4 μm, p = 0.057).
Conclusion
The prevalence of ODD in patients diagnosed with NTG is substantially higher than in the background population. A low cup/disc ratio correlates with ODD presence. Therefore, due to the challenges associated with NTG diagnosis, we recommend examining the deep layers of the ONH in NTG patients with a cup/disc ratio lower than 0.5 to avoid misdiagnosing ODD as NTG.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.15286</identifier><identifier>PMID: 36373859</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Canals (anatomy) ; Cross-Sectional Studies ; Eye ; Glaucoma ; Humans ; Intraocular Pressure ; Low Tension Glaucoma - diagnosis ; Low Tension Glaucoma - epidemiology ; normal tension glaucoma ; optic disc drusen ; Optic Disk ; Optic Disk Drusen - diagnosis ; Optic Disk Drusen - epidemiology ; Optic nerve ; optic nerve head drusen ; optic neuropathies ; optical coherence tomography ; Prospective Studies ; Tomography, Optical Coherence</subject><ispartof>Acta ophthalmologica (Oxford, England), 2023-05, Vol.101 (3), p.277-284</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.</rights><rights>2022 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3486-6a7adef8d3c3f78e222dd50cc4ac485c248b9d2e283589bf357098878e37cb6c3</cites><orcidid>0000-0001-8697-0734 ; 0000-0003-4318-2716 ; 0000-0002-0135-3129</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.15286$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.15286$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36373859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmadi, Hamid</creatorcontrib><creatorcontrib>Fotesko, Kyrylo</creatorcontrib><creatorcontrib>Ba‐Ali, Shakoor</creatorcontrib><creatorcontrib>Hamann, Steffen</creatorcontrib><creatorcontrib>Kolko, Miriam</creatorcontrib><title>Optic disc drusen in patients diagnosed with normal tension glaucoma</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To investigate the prevalence of optic disc drusen (ODD) and optic nerve head (ONH) morphology in patients diagnosed with normal tension glaucoma (NTG).
Methods
In this prospective cross‐sectional study, we included patients diagnosed with NTG from two glaucoma units. In both eyes, dense enhanced depth imaging optical coherence tomography volume scans of the ONH by means of standardized scanning guidelines were performed to examine for presence of ODD, and radial ONH scans were used for investigating parameters such as scleral canal diameter, cup/disc ratio and cup depth.
Results
We found ODD in 7 (3.6%) of 195 eyes, in 6 (6.1%) out of 98 patients diagnosed with NTG. The ODD were not ophthalmoscopically visible in five out of six patients. Eyes with ODD had lower cup/disc ratio, 0.44 ± 0.4 (p = 0.040), and less‐prominent cup depth, 236.6 ± 204.4 μm (p = 0.041) compared to eyes without ODD, 0.81 ± 0.2 and 437.8 ± 139.1 μm, respectively. We found no significant difference in scleral canal diameter between the eyes without (1602.8 ± 193 μm) and those with ODD (1492 ± 123.4 μm, p = 0.057).
Conclusion
The prevalence of ODD in patients diagnosed with NTG is substantially higher than in the background population. A low cup/disc ratio correlates with ODD presence. Therefore, due to the challenges associated with NTG diagnosis, we recommend examining the deep layers of the ONH in NTG patients with a cup/disc ratio lower than 0.5 to avoid misdiagnosing ODD as NTG.</description><subject>Canals (anatomy)</subject><subject>Cross-Sectional Studies</subject><subject>Eye</subject><subject>Glaucoma</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Low Tension Glaucoma - diagnosis</subject><subject>Low Tension Glaucoma - epidemiology</subject><subject>normal tension glaucoma</subject><subject>optic disc drusen</subject><subject>Optic Disk</subject><subject>Optic Disk Drusen - diagnosis</subject><subject>Optic Disk Drusen - epidemiology</subject><subject>Optic nerve</subject><subject>optic nerve head drusen</subject><subject>optic neuropathies</subject><subject>optical coherence tomography</subject><subject>Prospective Studies</subject><subject>Tomography, Optical Coherence</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp10E1LwzAcBvAgipvTg19ACl700C1Nmpcex3yFwQ4qeAtpks6ONqlNy9i3N9q5g2AOSQg_Hv55ALhM4DQJayadnyYEcXoExgkjJMaM8uPDnbyPwJn3GwhpQml6CkaYYoY5ycbgbtV0pYp06cPW9t7YqLRRI7vS2M6Hd7m2zhsdbcvuI7KurWUVdcb60tloXcleuVqeg5NCVt5c7M8JeHu4f108xcvV4_NivowVTjmNqWRSm4JrrHDBuEEIaU2gUqlUKScKpTzPNDKIY8KzvMCEwYzzIDFTOVV4Am6G3KZ1n73xnajD3KaqpDWu9wKx8DGYQgoDvf5DN65vbZguqIyHcShGQd0OSrXO-9YUomnLWrY7kUDxXa0I1YqfaoO92if2eW30Qf52GcBsANuyMrv_k8R89TJEfgFNZYIW</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Ahmadi, Hamid</creator><creator>Fotesko, Kyrylo</creator><creator>Ba‐Ali, Shakoor</creator><creator>Hamann, Steffen</creator><creator>Kolko, Miriam</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8697-0734</orcidid><orcidid>https://orcid.org/0000-0003-4318-2716</orcidid><orcidid>https://orcid.org/0000-0002-0135-3129</orcidid></search><sort><creationdate>202305</creationdate><title>Optic disc drusen in patients diagnosed with normal tension glaucoma</title><author>Ahmadi, Hamid ; Fotesko, Kyrylo ; Ba‐Ali, Shakoor ; Hamann, Steffen ; Kolko, Miriam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3486-6a7adef8d3c3f78e222dd50cc4ac485c248b9d2e283589bf357098878e37cb6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Canals (anatomy)</topic><topic>Cross-Sectional Studies</topic><topic>Eye</topic><topic>Glaucoma</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Low Tension Glaucoma - diagnosis</topic><topic>Low Tension Glaucoma - epidemiology</topic><topic>normal tension glaucoma</topic><topic>optic disc drusen</topic><topic>Optic Disk</topic><topic>Optic Disk Drusen - diagnosis</topic><topic>Optic Disk Drusen - epidemiology</topic><topic>Optic nerve</topic><topic>optic nerve head drusen</topic><topic>optic neuropathies</topic><topic>optical coherence tomography</topic><topic>Prospective Studies</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmadi, Hamid</creatorcontrib><creatorcontrib>Fotesko, Kyrylo</creatorcontrib><creatorcontrib>Ba‐Ali, Shakoor</creatorcontrib><creatorcontrib>Hamann, Steffen</creatorcontrib><creatorcontrib>Kolko, Miriam</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmadi, Hamid</au><au>Fotesko, Kyrylo</au><au>Ba‐Ali, Shakoor</au><au>Hamann, Steffen</au><au>Kolko, Miriam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optic disc drusen in patients diagnosed with normal tension glaucoma</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>101</volume><issue>3</issue><spage>277</spage><epage>284</epage><pages>277-284</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To investigate the prevalence of optic disc drusen (ODD) and optic nerve head (ONH) morphology in patients diagnosed with normal tension glaucoma (NTG).
Methods
In this prospective cross‐sectional study, we included patients diagnosed with NTG from two glaucoma units. In both eyes, dense enhanced depth imaging optical coherence tomography volume scans of the ONH by means of standardized scanning guidelines were performed to examine for presence of ODD, and radial ONH scans were used for investigating parameters such as scleral canal diameter, cup/disc ratio and cup depth.
Results
We found ODD in 7 (3.6%) of 195 eyes, in 6 (6.1%) out of 98 patients diagnosed with NTG. The ODD were not ophthalmoscopically visible in five out of six patients. Eyes with ODD had lower cup/disc ratio, 0.44 ± 0.4 (p = 0.040), and less‐prominent cup depth, 236.6 ± 204.4 μm (p = 0.041) compared to eyes without ODD, 0.81 ± 0.2 and 437.8 ± 139.1 μm, respectively. We found no significant difference in scleral canal diameter between the eyes without (1602.8 ± 193 μm) and those with ODD (1492 ± 123.4 μm, p = 0.057).
Conclusion
The prevalence of ODD in patients diagnosed with NTG is substantially higher than in the background population. A low cup/disc ratio correlates with ODD presence. Therefore, due to the challenges associated with NTG diagnosis, we recommend examining the deep layers of the ONH in NTG patients with a cup/disc ratio lower than 0.5 to avoid misdiagnosing ODD as NTG.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36373859</pmid><doi>10.1111/aos.15286</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8697-0734</orcidid><orcidid>https://orcid.org/0000-0003-4318-2716</orcidid><orcidid>https://orcid.org/0000-0002-0135-3129</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Canals (anatomy) Cross-Sectional Studies Eye Glaucoma Humans Intraocular Pressure Low Tension Glaucoma - diagnosis Low Tension Glaucoma - epidemiology normal tension glaucoma optic disc drusen Optic Disk Optic Disk Drusen - diagnosis Optic Disk Drusen - epidemiology Optic nerve optic nerve head drusen optic neuropathies optical coherence tomography Prospective Studies Tomography, Optical Coherence |
| title | Optic disc drusen in patients diagnosed with normal tension glaucoma |
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