Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke
Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) may alter miRNA transcription, maturation and target specificity, thus affecting stroke susceptibility. We aimed to investigate whether miR-200b and miR-495 SNPs may be associated with ischemic stroke (IS) risk and further explore underlyi...
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| creator | Qin, Shanmei Shen, Chong Tang, Wuzhuang Wang, Mengmeng Lin, Ying Wang, Zhaojun Li, Yunzi Zhang, Zhizhong Liu, Xinfeng |
| description | Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) may alter miRNA transcription, maturation and target specificity, thus affecting stroke susceptibility. We aimed to investigate whether miR-200b and miR-495 SNPs may be associated with ischemic stroke (IS) risk and further explore underlying mechanisms including related genes and pathways. MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case–control study. Bioinformatic analyses were performed to explore potential association of miR-200b/495 with IS and to examine the effects of these two SNPs on miR-200b/495. Furthermore, we evaluated the association between these two SNPs and stroke using the public GWAS datasets. In our case–control study, rs7549819 was significantly associated with a decreased risk of LAA stroke (OR = 0.73, 95% CI = 0.58–0.92;
p
= 0.007), while rs2281611 had no significant association with LAA stroke risk. These results were consistent with the findings in East Asians from the GIGASTROKE study. Combined effects analysis revealed that individuals with 2–4 protective alleles (miR-200bC and miR-495 T) exhibited lower risk of LAA stroke than those with 0–1 variants (OR = 0.76, 95% CI = 0.61–0.96;
p
= 0.021). Bioinformatic analyses showed that miR-200b and miR-495 were significantly associated with genes and pathways related to IS pathogenesis, and rs7549819 and rs2281611 markedly influenced miRNA expression and structure. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population. |
| doi_str_mv | 10.1007/s11011-022-01119-w |
| format | Article |
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p
= 0.007), while rs2281611 had no significant association with LAA stroke risk. These results were consistent with the findings in East Asians from the GIGASTROKE study. Combined effects analysis revealed that individuals with 2–4 protective alleles (miR-200bC and miR-495 T) exhibited lower risk of LAA stroke than those with 0–1 variants (OR = 0.76, 95% CI = 0.61–0.96;
p
= 0.021). Bioinformatic analyses showed that miR-200b and miR-495 were significantly associated with genes and pathways related to IS pathogenesis, and rs7549819 and rs2281611 markedly influenced miRNA expression and structure. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-022-01119-w</identifier><identifier>PMID: 36374407</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arteries ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - genetics ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Gene polymorphism ; Genes ; Genotypes ; Health risks ; Humans ; Ischemia ; Ischemic Stroke - genetics ; Metabolic Diseases ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Neurology ; Neurosciences ; Nucleotides ; Oncology ; Original Article ; Pathogenesis ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Risk ; Risk reduction ; Single-nucleotide polymorphism ; Stroke</subject><ispartof>Metabolic brain disease, 2023-02, Vol.38 (2), p.631-639</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-722d7104389282c1374128de9a5aeee6eca98f11b30be382036825f436d82d3c3</citedby><cites>FETCH-LOGICAL-c375t-722d7104389282c1374128de9a5aeee6eca98f11b30be382036825f436d82d3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-022-01119-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-022-01119-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36374407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Shanmei</creatorcontrib><creatorcontrib>Shen, Chong</creatorcontrib><creatorcontrib>Tang, Wuzhuang</creatorcontrib><creatorcontrib>Wang, Mengmeng</creatorcontrib><creatorcontrib>Lin, Ying</creatorcontrib><creatorcontrib>Wang, Zhaojun</creatorcontrib><creatorcontrib>Li, Yunzi</creatorcontrib><creatorcontrib>Zhang, Zhizhong</creatorcontrib><creatorcontrib>Liu, Xinfeng</creatorcontrib><title>Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) may alter miRNA transcription, maturation and target specificity, thus affecting stroke susceptibility. We aimed to investigate whether miR-200b and miR-495 SNPs may be associated with ischemic stroke (IS) risk and further explore underlying mechanisms including related genes and pathways. MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case–control study. Bioinformatic analyses were performed to explore potential association of miR-200b/495 with IS and to examine the effects of these two SNPs on miR-200b/495. Furthermore, we evaluated the association between these two SNPs and stroke using the public GWAS datasets. In our case–control study, rs7549819 was significantly associated with a decreased risk of LAA stroke (OR = 0.73, 95% CI = 0.58–0.92;
p
= 0.007), while rs2281611 had no significant association with LAA stroke risk. These results were consistent with the findings in East Asians from the GIGASTROKE study. Combined effects analysis revealed that individuals with 2–4 protective alleles (miR-200bC and miR-495 T) exhibited lower risk of LAA stroke than those with 0–1 variants (OR = 0.76, 95% CI = 0.61–0.96;
p
= 0.021). Bioinformatic analyses showed that miR-200b and miR-495 were significantly associated with genes and pathways related to IS pathogenesis, and rs7549819 and rs2281611 markedly influenced miRNA expression and structure. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.</description><subject>Arteries</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - genetics</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genotypes</subject><subject>Health risks</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Ischemic Stroke - genetics</subject><subject>Metabolic Diseases</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nucleotides</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pathogenesis</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk</subject><subject>Risk reduction</subject><subject>Single-nucleotide polymorphism</subject><subject>Stroke</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEtLAzEQgIMotlb_gAcJePESnSSbTfYoxRcUBNGLl5Duzuq2-6jJ1tJ_b2p9gAcvGcJ88_oIOeZwzgH0ReAcOGcgBIuRZ2y1Q4Zcacm0TNUuGYIxiukkgwE5CGEGAFLxbJ8MZCp1koAekue7ZuHynnYlbaoHJgCm1LXF5yfJFH13vnJtH2jX0v4Vqa_CfAPXzr8gc75Hv6YuZnwX8nrzVoGG3ndzPCR7pasDHn3FEXm6vnoc37LJ_c3d-HLCcqlVz7QQheaQSJMJI3IeN-PCFJg55RAxxdxlpuR8KmGK0giQqRGqTGRaGFHIXI7I2bbvwndvSwy9baqQY127FrtlsCLakPHyTET09A8665a-jdtFKtVS6RTSSIktlcdzgsfSLnzVOL-2HOzGvN2at9G8_TRvV7Ho5Kv1ctpg8VPyrToCcguEmGpf0P_O_qftB31WjBM</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Qin, Shanmei</creator><creator>Shen, Chong</creator><creator>Tang, Wuzhuang</creator><creator>Wang, Mengmeng</creator><creator>Lin, Ying</creator><creator>Wang, Zhaojun</creator><creator>Li, Yunzi</creator><creator>Zhang, Zhizhong</creator><creator>Liu, Xinfeng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20230201</creationdate><title>Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke</title><author>Qin, Shanmei ; 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We aimed to investigate whether miR-200b and miR-495 SNPs may be associated with ischemic stroke (IS) risk and further explore underlying mechanisms including related genes and pathways. MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case–control study. Bioinformatic analyses were performed to explore potential association of miR-200b/495 with IS and to examine the effects of these two SNPs on miR-200b/495. Furthermore, we evaluated the association between these two SNPs and stroke using the public GWAS datasets. In our case–control study, rs7549819 was significantly associated with a decreased risk of LAA stroke (OR = 0.73, 95% CI = 0.58–0.92;
p
= 0.007), while rs2281611 had no significant association with LAA stroke risk. These results were consistent with the findings in East Asians from the GIGASTROKE study. Combined effects analysis revealed that individuals with 2–4 protective alleles (miR-200bC and miR-495 T) exhibited lower risk of LAA stroke than those with 0–1 variants (OR = 0.76, 95% CI = 0.61–0.96;
p
= 0.021). Bioinformatic analyses showed that miR-200b and miR-495 were significantly associated with genes and pathways related to IS pathogenesis, and rs7549819 and rs2281611 markedly influenced miRNA expression and structure. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36374407</pmid><doi>10.1007/s11011-022-01119-w</doi><tpages>9</tpages></addata></record> |
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| subjects | Arteries Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Biochemistry Biomedical and Life Sciences Biomedicine Case-Control Studies Gene polymorphism Genes Genotypes Health risks Humans Ischemia Ischemic Stroke - genetics Metabolic Diseases MicroRNAs MicroRNAs - genetics miRNA Neurology Neurosciences Nucleotides Oncology Original Article Pathogenesis Polymorphism Polymorphism, Single Nucleotide - genetics Risk Risk reduction Single-nucleotide polymorphism Stroke |
| title | Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke |
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