Genome-Wide Association with Uncertainty in the Genetic Similarity Matrix

Genome-wide association studies (GWASs) are often confounded by population stratification and structure. Linear mixed models (LMMs) are a powerful class of methods for uncovering genetic effects, while controlling for such confounding. LMMs include random effects for a genetic similarity matrix, and...

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Veröffentlicht in:	Journal of computational biology 2023-02, Vol.30 (2), p.189-203
Hauptverfasser:	Wang, Shijia, Ge, Shufei, Sobkowiak, Benjamin, Wang, Liangliang, Grandjean, Louis, Colijn, Caroline, Elliott, Lloyd T
Format:	Artikel
Sprache:	eng
Schlagworte:	Genome-Wide Association Study - methods Humans Linear Models Models, Genetic Phylogeny Polymorphism, Single Nucleotide Uncertainty
Online-Zugang:	Volltext
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