Distribution of proteins for synaptic release in nerve endings associated with the trachealis muscle of rats

The immunohistochemical localization of proteins for synaptic release was examined in smooth muscle-associated sensory nerve endings using whole-mount preparations of the rat trachea. Plant-like smooth muscle-associated nerve endings with immunoreactivity for Na+-K+-ATPase, α3-subunit were identifie...

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Veröffentlicht in:	Autonomic neuroscience 2023-01, Vol.244, p.103042-103042, Article 103042
Hauptverfasser:	Moriai, Hisae, Yokoyama, Takuya, Abdali, Sayed Sharif, Nakamuta, Nobuaki, Yamamoto, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glutamate Immunohistochemistry Muscle, Smooth - innervation Nerve Endings Rats Rats, Wistar Sensory Receptor Cells Slowly adapting receptor SNARE proteins Trachealis muscle
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creator	Moriai, Hisae Yokoyama, Takuya Abdali, Sayed Sharif Nakamuta, Nobuaki Yamamoto, Yoshio
description	The immunohistochemical localization of proteins for synaptic release was examined in smooth muscle-associated sensory nerve endings using whole-mount preparations of the rat trachea. Plant-like smooth muscle-associated nerve endings with immunoreactivity for Na+-K+-ATPase, α3-subunit were identified in the trachealis muscle. VGLUT1, synapsin1, t-SNARE proteins (SNAP25 and syntaxin1), v-SNARE proteins (VAMP1 and VAMP2), and a presynaptic active zone-related protein (piccolo) were detected in the terminal parts of these endings. These results suggest that smooth muscle-associated nerve endings secrete glutamate to modulate sensorimotor functions in the lung deflation reflex.
doi_str_mv	10.1016/j.autneu.2022.103042
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Plant-like smooth muscle-associated nerve endings with immunoreactivity for Na+-K+-ATPase, α3-subunit were identified in the trachealis muscle. VGLUT1, synapsin1, t-SNARE proteins (SNAP25 and syntaxin1), v-SNARE proteins (VAMP1 and VAMP2), and a presynaptic active zone-related protein (piccolo) were detected in the terminal parts of these endings. 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subjects	Animals Glutamate Immunohistochemistry Muscle, Smooth - innervation Nerve Endings Rats Rats, Wistar Sensory Receptor Cells Slowly adapting receptor SNARE proteins Trachealis muscle
title	Distribution of proteins for synaptic release in nerve endings associated with the trachealis muscle of rats
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