Motor neurons transplantation alleviates neurofibrogenesis during chronic degeneration by reversibly regulating Schwann cells epithelial-mesenchymal transition

A novel understanding of peripheral nerve injury is epithelial-mesenchymal transition (EMT), which characterizes the process of dedifferentiation and transformation of Schwann cells after nerve injury. Despite being regarded as an important mechanism for healing nerve injuries, long-term EMT is the...

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Veröffentlicht in:	Experimental neurology 2023-01, Vol.359, p.114272-114272, Article 114272
Hauptverfasser:	Wu, Zhaoyang, Ding, Haiqi, Chen, Yang, Huang, Changyu, Chen, Xiaoqing, Hu, Hongxin, Chen, Yongfa, Zhang, Wenming, Fang, Xinyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Epithelial-Mesenchymal Transition Epithelial-mesenchymal transitions Motor Neurons - metabolism Neurofibrosis Schwann Cells - metabolism Signal Transduction Snai2 TGFβ-1 signaling pathway Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology
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