MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition
Cognitive improvement has been reported after carotid revascularization and attributed to treating stenosis and correcting hypoperfusion. This study investigated the effect of carotid intraplaque hemorrhage on postintervention cognition. In this institutional review board-approved single-center stud...
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| Veröffentlicht in: | American journal of neuroradiology : AJNR 2022-12, Vol.43 (12), p.1762-1769 |
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| creator | Culleton, S Baradaran, H Kim, S-E Stoddard, G Roberts, J Treiman, G Parker, D Duff, K McNally, J S |
| description | Cognitive improvement has been reported after carotid revascularization and attributed to treating stenosis and correcting hypoperfusion. This study investigated the effect of carotid intraplaque hemorrhage on postintervention cognition.
In this institutional review board-approved single-center study, consecutive patients scheduled for carotid surgery were recruited for preoperative carotid MR imaging (MPRAGE) and pre- and postintervention cognitive testing using the Repeatable Battery for the Assessment of Neuropsychological Status. Pre- and postintervention scores were compared using
tests and multivariable linear regression.
Twenty-three participants were included, with endarterectomy performed in 20 (87%) and angioplasty/stent placement, in 3 (13%). Overall, statistically significant improvements occurred in the pre- versus postintervention mean Total Scale score (92.1 [SD, 15.5] versus 96.1 [SD, 15.8],
= .04), immediate memory index (89.4 [SD, 18.2] versus 97.7 [SD, 14.9], |
| doi_str_mv | 10.3174/ajnr.A7701 |
| format | Article |
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In this institutional review board-approved single-center study, consecutive patients scheduled for carotid surgery were recruited for preoperative carotid MR imaging (MPRAGE) and pre- and postintervention cognitive testing using the Repeatable Battery for the Assessment of Neuropsychological Status. Pre- and postintervention scores were compared using
tests and multivariable linear regression.
Twenty-three participants were included, with endarterectomy performed in 20 (87%) and angioplasty/stent placement, in 3 (13%). Overall, statistically significant improvements occurred in the pre- versus postintervention mean Total Scale score (92.1 [SD, 15.5] versus 96.1 [SD, 15.8],
= .04), immediate memory index (89.4 [SD, 18.2] versus 97.7 [SD, 14.9],
< .001), and verbal index (96.1 [SD, 14.1] versus 103.0 [SD, 12.0],
= .002). Intraplaque hemorrhage (+) participants (
= 11) had no significant improvement in any category, and the attention index significantly decreased (99.4 [SD, 18.0] versus 93.5 [SD, 19.4],
= .045). Intraplaque hemorrhage (-) participants (
= 12) significantly improved in the Total Scale score (86.4 [SD, 11.8] versus 95.5 [SD, 12.4],
= .004), immediate memory index (82.3 [SD, 14.6] versus 96.2 [SD, 14.1],
= .002), delayed memory index (94.3 [SD, 14.9] versus 102.4 [SD, 8.0],
= .03), and verbal index (94.3 [SD, 13.2] versus 101.5 [SD, 107.4],
= .009). Postintervention minus preintervention scores for intraplaque hemorrhage (+) versus (-) groups showed statistically significant differences in the Total Scale score (-0.4 [SD, 6.8] versus 8.0 [SD, 8.5],
= .02), attention index (-5.9 [SD, 8.5] versus 4.3 [SD, 11.9],
= .03), and immediate memory index (4.2 [SD, 6.7] versus 12.2 [SD, 10.2],
= .04).
Cognitive improvement was observed after carotid intervention, and this was attributable to intraplaque hemorrhage (-) plaque. MR imaging detection of intraplaque hemorrhage status may be an important determinant of cognitive change after intervention.</description><identifier>ISSN: 0195-6108</identifier><identifier>ISSN: 1936-959X</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A7701</identifier><identifier>PMID: 36357151</identifier><language>eng</language><publisher>United States</publisher><subject>Carotid Arteries - diagnostic imaging ; Carotid Arteries - surgery ; Carotid Stenosis - complications ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - surgery ; Cognition ; Endarterectomy, Carotid ; Hemorrhage - diagnostic imaging ; Hemorrhage - etiology ; Hemorrhage - therapy ; Humans ; Magnetic Resonance Imaging - methods ; Plaque, Atherosclerotic</subject><ispartof>American journal of neuroradiology : AJNR, 2022-12, Vol.43 (12), p.1762-1769</ispartof><rights>2022 by American Journal of Neuroradiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c282t-861764da566ad5029c15631b134056f373458c36df0b7477f438a6e1a0b0340a3</cites><orcidid>0000-0002-6292-276X ; 0000-0002-9336-2400 ; 0000-0001-8394-045X ; 0000-0003-2557-8952 ; 0000-0002-1786-0969 ; 0000-0002-1376-2536 ; 0000-0003-3770-1153 ; 0000-0002-7232-3621 ; 0000-0002-6251-5769</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36357151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Culleton, S</creatorcontrib><creatorcontrib>Baradaran, H</creatorcontrib><creatorcontrib>Kim, S-E</creatorcontrib><creatorcontrib>Stoddard, G</creatorcontrib><creatorcontrib>Roberts, J</creatorcontrib><creatorcontrib>Treiman, G</creatorcontrib><creatorcontrib>Parker, D</creatorcontrib><creatorcontrib>Duff, K</creatorcontrib><creatorcontrib>McNally, J S</creatorcontrib><title>MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Cognitive improvement has been reported after carotid revascularization and attributed to treating stenosis and correcting hypoperfusion. This study investigated the effect of carotid intraplaque hemorrhage on postintervention cognition.
In this institutional review board-approved single-center study, consecutive patients scheduled for carotid surgery were recruited for preoperative carotid MR imaging (MPRAGE) and pre- and postintervention cognitive testing using the Repeatable Battery for the Assessment of Neuropsychological Status. Pre- and postintervention scores were compared using
tests and multivariable linear regression.
Twenty-three participants were included, with endarterectomy performed in 20 (87%) and angioplasty/stent placement, in 3 (13%). Overall, statistically significant improvements occurred in the pre- versus postintervention mean Total Scale score (92.1 [SD, 15.5] versus 96.1 [SD, 15.8],
= .04), immediate memory index (89.4 [SD, 18.2] versus 97.7 [SD, 14.9],
< .001), and verbal index (96.1 [SD, 14.1] versus 103.0 [SD, 12.0],
= .002). Intraplaque hemorrhage (+) participants (
= 11) had no significant improvement in any category, and the attention index significantly decreased (99.4 [SD, 18.0] versus 93.5 [SD, 19.4],
= .045). Intraplaque hemorrhage (-) participants (
= 12) significantly improved in the Total Scale score (86.4 [SD, 11.8] versus 95.5 [SD, 12.4],
= .004), immediate memory index (82.3 [SD, 14.6] versus 96.2 [SD, 14.1],
= .002), delayed memory index (94.3 [SD, 14.9] versus 102.4 [SD, 8.0],
= .03), and verbal index (94.3 [SD, 13.2] versus 101.5 [SD, 107.4],
= .009). Postintervention minus preintervention scores for intraplaque hemorrhage (+) versus (-) groups showed statistically significant differences in the Total Scale score (-0.4 [SD, 6.8] versus 8.0 [SD, 8.5],
= .02), attention index (-5.9 [SD, 8.5] versus 4.3 [SD, 11.9],
= .03), and immediate memory index (4.2 [SD, 6.7] versus 12.2 [SD, 10.2],
= .04).
Cognitive improvement was observed after carotid intervention, and this was attributable to intraplaque hemorrhage (-) plaque. MR imaging detection of intraplaque hemorrhage status may be an important determinant of cognitive change after intervention.</description><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - surgery</subject><subject>Carotid Stenosis - complications</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - surgery</subject><subject>Cognition</subject><subject>Endarterectomy, Carotid</subject><subject>Hemorrhage - diagnostic imaging</subject><subject>Hemorrhage - etiology</subject><subject>Hemorrhage - therapy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Plaque, Atherosclerotic</subject><issn>0195-6108</issn><issn>1936-959X</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMobk5v_AGSSxE6T5omaS9Hp24wPxAF70LaprOjTWaSCf57uw-9es_Fc15eHoQuCYwpEcmtWhk3nggB5AgNSUZ5lLHs4xgNgWQs4gTSATrzfgUALBPxKRpQTpkgjAzR0-PrHE910GVorMG2xrlyNjQVnpvg1LpVXxuNZ7qzzn2qpcbKVPjF-tCYoN23Nru33C5Ns73O0UmtWq8vDjlC7_d3b_ksWjw_zPPJIirjNA5RyongSaUY56piEGclYZySgtAEGK-poAlLS8qrGgqRCFEnNFVcEwUF9IiiI3S971072w_0QXaNL3XbKqPtxstYUJYKSBj06M0eLZ313ularl3TKfcjCcitP7n1J3f-evjq0LspOl39o3_C6C-oR2qX</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Culleton, S</creator><creator>Baradaran, H</creator><creator>Kim, S-E</creator><creator>Stoddard, G</creator><creator>Roberts, J</creator><creator>Treiman, G</creator><creator>Parker, D</creator><creator>Duff, K</creator><creator>McNally, J S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6292-276X</orcidid><orcidid>https://orcid.org/0000-0002-9336-2400</orcidid><orcidid>https://orcid.org/0000-0001-8394-045X</orcidid><orcidid>https://orcid.org/0000-0003-2557-8952</orcidid><orcidid>https://orcid.org/0000-0002-1786-0969</orcidid><orcidid>https://orcid.org/0000-0002-1376-2536</orcidid><orcidid>https://orcid.org/0000-0003-3770-1153</orcidid><orcidid>https://orcid.org/0000-0002-7232-3621</orcidid><orcidid>https://orcid.org/0000-0002-6251-5769</orcidid></search><sort><creationdate>202212</creationdate><title>MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition</title><author>Culleton, S ; Baradaran, H ; Kim, S-E ; Stoddard, G ; Roberts, J ; Treiman, G ; Parker, D ; Duff, K ; McNally, J S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-861764da566ad5029c15631b134056f373458c36df0b7477f438a6e1a0b0340a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - surgery</topic><topic>Carotid Stenosis - complications</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - surgery</topic><topic>Cognition</topic><topic>Endarterectomy, Carotid</topic><topic>Hemorrhage - diagnostic imaging</topic><topic>Hemorrhage - etiology</topic><topic>Hemorrhage - therapy</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Plaque, Atherosclerotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Culleton, S</creatorcontrib><creatorcontrib>Baradaran, H</creatorcontrib><creatorcontrib>Kim, S-E</creatorcontrib><creatorcontrib>Stoddard, G</creatorcontrib><creatorcontrib>Roberts, J</creatorcontrib><creatorcontrib>Treiman, G</creatorcontrib><creatorcontrib>Parker, D</creatorcontrib><creatorcontrib>Duff, K</creatorcontrib><creatorcontrib>McNally, J S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Culleton, S</au><au>Baradaran, H</au><au>Kim, S-E</au><au>Stoddard, G</au><au>Roberts, J</au><au>Treiman, G</au><au>Parker, D</au><au>Duff, K</au><au>McNally, J S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>43</volume><issue>12</issue><spage>1762</spage><epage>1769</epage><pages>1762-1769</pages><issn>0195-6108</issn><issn>1936-959X</issn><eissn>1936-959X</eissn><abstract>Cognitive improvement has been reported after carotid revascularization and attributed to treating stenosis and correcting hypoperfusion. This study investigated the effect of carotid intraplaque hemorrhage on postintervention cognition.
In this institutional review board-approved single-center study, consecutive patients scheduled for carotid surgery were recruited for preoperative carotid MR imaging (MPRAGE) and pre- and postintervention cognitive testing using the Repeatable Battery for the Assessment of Neuropsychological Status. Pre- and postintervention scores were compared using
tests and multivariable linear regression.
Twenty-three participants were included, with endarterectomy performed in 20 (87%) and angioplasty/stent placement, in 3 (13%). Overall, statistically significant improvements occurred in the pre- versus postintervention mean Total Scale score (92.1 [SD, 15.5] versus 96.1 [SD, 15.8],
= .04), immediate memory index (89.4 [SD, 18.2] versus 97.7 [SD, 14.9],
< .001), and verbal index (96.1 [SD, 14.1] versus 103.0 [SD, 12.0],
= .002). Intraplaque hemorrhage (+) participants (
= 11) had no significant improvement in any category, and the attention index significantly decreased (99.4 [SD, 18.0] versus 93.5 [SD, 19.4],
= .045). Intraplaque hemorrhage (-) participants (
= 12) significantly improved in the Total Scale score (86.4 [SD, 11.8] versus 95.5 [SD, 12.4],
= .004), immediate memory index (82.3 [SD, 14.6] versus 96.2 [SD, 14.1],
= .002), delayed memory index (94.3 [SD, 14.9] versus 102.4 [SD, 8.0],
= .03), and verbal index (94.3 [SD, 13.2] versus 101.5 [SD, 107.4],
= .009). Postintervention minus preintervention scores for intraplaque hemorrhage (+) versus (-) groups showed statistically significant differences in the Total Scale score (-0.4 [SD, 6.8] versus 8.0 [SD, 8.5],
= .02), attention index (-5.9 [SD, 8.5] versus 4.3 [SD, 11.9],
= .03), and immediate memory index (4.2 [SD, 6.7] versus 12.2 [SD, 10.2],
= .04).
Cognitive improvement was observed after carotid intervention, and this was attributable to intraplaque hemorrhage (-) plaque. MR imaging detection of intraplaque hemorrhage status may be an important determinant of cognitive change after intervention.</abstract><cop>United States</cop><pmid>36357151</pmid><doi>10.3174/ajnr.A7701</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6292-276X</orcidid><orcidid>https://orcid.org/0000-0002-9336-2400</orcidid><orcidid>https://orcid.org/0000-0001-8394-045X</orcidid><orcidid>https://orcid.org/0000-0003-2557-8952</orcidid><orcidid>https://orcid.org/0000-0002-1786-0969</orcidid><orcidid>https://orcid.org/0000-0002-1376-2536</orcidid><orcidid>https://orcid.org/0000-0003-3770-1153</orcidid><orcidid>https://orcid.org/0000-0002-7232-3621</orcidid><orcidid>https://orcid.org/0000-0002-6251-5769</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0195-6108 1936-959X 1936-959X |
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| subjects | Carotid Arteries - diagnostic imaging Carotid Arteries - surgery Carotid Stenosis - complications Carotid Stenosis - diagnostic imaging Carotid Stenosis - surgery Cognition Endarterectomy, Carotid Hemorrhage - diagnostic imaging Hemorrhage - etiology Hemorrhage - therapy Humans Magnetic Resonance Imaging - methods Plaque, Atherosclerotic |
| title | MRI Detection of Carotid Intraplaque Hemorrhage and Postintervention Cognition |
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