Fibroblasts and mouse breast cancer cells can form cellular aggregates in improved soft agar culture medium

We aimed to build cellular aggregates of TS/A and normal fibroblasts (LX-2) or CAFs (ME-iLX-2), verifying the value of this model in the screening of anticancer drugs and demonstrating the effect of CD44 on aggregate formation. We improved soft agar culture medium to coculture CAFs (NFs) and TS/A an...

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Veröffentlicht in:	Molecular and cellular biochemistry 2023-07, Vol.478 (7), p.1457-1464
Hauptverfasser:	Zhang, Xiangnan, Liang, Shuo, Wang, Enze, Tao, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Aggregates Analysis Animals Antineoplastic drugs Antitumor agents Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms Cancer Cancer cells Cancer Research Cardiology Care and treatment CD44 antigen Cell culture Cell Line, Tumor Cell Proliferation Coculture Techniques Culture Culture Media Drug screening Drugs Eugenol Female Fibroblasts Humans Life Sciences Medical Biochemistry Mice Model testing Screening
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