Impairment of patient‐reported outcomes among patients with non‐alcoholic fatty liver disease: a registry‐based study

Summary Background Patients with non‐alcoholic fatty liver disease (NAFLD) and more advanced fibrosis tend to have more impairment in their health‐related quality of life and other patient‐reported outcomes (PROs). Aim To assess the association of PROs with select non‐invasive tests (NITs) for fibro...

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Veröffentlicht in:Alimentary pharmacology & therapeutics 2023-01, Vol.57 (2), p.215-223
Hauptverfasser: Yilmaz, Yusuf, Toraman, Ahmet Eren, Alp, Ceyda, Doğan, Zehra, Keklikkiran, Caglayan, Stepanova, Maria, Younossi, Zobair
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Sprache:eng
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Zusammenfassung:Summary Background Patients with non‐alcoholic fatty liver disease (NAFLD) and more advanced fibrosis tend to have more impairment in their health‐related quality of life and other patient‐reported outcomes (PROs). Aim To assess the association of PROs with select non‐invasive tests (NITs) for fibrosis including FAST, Agile 3+ and Agile 4 scores Methods We enrolled patients with an established diagnosis of NAFLD who were seen in a tertiary care clinic into the NAFLD/NASH Registry. The FAST, Agile 3+ and Agile 4 scores were calculated using liver stiffness measurements by transient elastography and laboratory parameters. PROs were assessed using FACIT‐F, CLDQ‐NASH and WPAI instruments (total of 17 domain and summary scores). Results There were 1509 patients with NAFLD (mean age: 49 ± 11 years, 50% men, 41% employed, 30% advanced fibrosis and 20% cirrhosis). The mean FAST, Agile 3+ and Agile 4 scores were 0.39 ± 0.26, 0.35 ± 0.31 and 0.12 ± 0.23, respectively. Subjects with lower FAST, Agile 3+ and Agile 4 scores had the highest scores in select domains of FACIT‐F, CLDQ‐NASH and WPAI (p 
ISSN:0269-2813
1365-2036
1365-2036
DOI:10.1111/apt.17301