Arc controls alcohol cue relapse by a central amygdala mechanism

Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence. The molecular mechanisms of cue-induced relapse are not well established, despite the fact that they may offer new targ...

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Veröffentlicht in:	Molecular psychiatry 2023-02, Vol.28 (2), p.733-745
Hauptverfasser:	Pagano, Roberto, Salamian, Ahmad, Zielinski, Janusz, Beroun, Anna, Nalberczak-Skóra, Maria, Skonieczna, Edyta, Cały, Anna, Tay, Nicole, Banaschewski, Tobias, Desrivières, Sylvane, Grigis, Antoine, Garavan, Hugh, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Kalita, Katarzyna, Bito, Haruhiko, Müller, Christian P., Schumann, Gunter, Okuno, Hiroyuki, Radwanska, Kasia
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 14 14/19 38 631/378 64/60 692/699/476/5 9/74 Abstinence Alcohol abuse Alcohol use Alcoholism - genetics Amygdala Animal models Animals ARC protein Behavior Behavioral Sciences Biological Psychology Biology Brain research Central Amygdaloid Nucleus Child & adolescent psychiatry Chronic Disease CRISPR Cues Cytoskeletal Proteins - metabolism Cytoskeleton DNA methylation Drug abuse Electrophysiology Ethanol Experiments Gene expression Humans Medicine Medicine & Public Health Molecular modelling Nerve Tissue Proteins - metabolism Neurosciences Pharmacotherapy Precision medicine Psychiatry Psychotherapy Recurrence Single-nucleotide polymorphism Synapses
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