Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors
Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high correlation with the laminin β-chain and promoted the growth of neurites in cultured olfactory bulb explants...
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| Veröffentlicht in: | Cellular and molecular neurobiology 2023-07, Vol.43 (5), p.1663-1683 |
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| container_title | Cellular and molecular neurobiology |
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| creator | Dong, Fuxing Liu, Yaping Yan, Weixing Meng, Qiqi Song, Xueli Cheng, Bing Yao, Ruiqin |
| description | Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high correlation with the laminin β-chain and promoted the growth of neurites in cultured olfactory bulb explants. Subsequently, it was discovered that Netrin-4 is involved in regulating various physiological processes, including angiogenesis, the occurrence and metastasis of various tumors, and the development of the kidney and alveoli. This paper reviews the current research on Netrin-4 since its discovery and provides a theoretical basis for further research on the biological characteristics of Netrin-4.
Graphical Abstract
Effects of Netrin-4. Netrin-4 regulates axon guidance, angiogenesis and the development of various tumors. |
| doi_str_mv | 10.1007/s10571-022-01279-4 |
| format | Article |
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Graphical Abstract
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Graphical Abstract
Effects of Netrin-4. Netrin-4 regulates axon guidance, angiogenesis and the development of various tumors.</description><subject>Angiogenesis</subject><subject>Axon guidance</subject><subject>Axonogenesis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Explants</subject><subject>Laminin</subject><subject>Metastases</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Olfactory bulb</subject><subject>Review Paper</subject><subject>Tumors</subject><issn>0272-4340</issn><issn>1573-6830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kM9rFTEQx0NR7LP6D_RQAl48NDa_s-ntUWwtFIX6xGPYTWYfKfuSNtkF-98bfbWCB08DM5_5zvBB6JjRD4xSc1YZVYYRyjmhjBtL5AFaMWUE0Z2gL9CKcsOJFJIeote13lFKLaXqFToUWiiqRLdC3z_DXGIi8hxfZr9UnBO-niu-zRPgmPD6R2tcLTH0ycMp3sRaF8Bf536IU5wfT_E6bWPeQoIaK-5TwJtll0t9g16O_VTh7VM9Qt8uP24uPpGbL1fXF-sb4oVRM1GDYRCC7DrLhFaD6nXQYmDWGhA8UG1Bjp0YlArG65FbO4oORj34AYIPXhyh9_vc-5IfFqiz28XqYZr6BHmpjhshNZOKqYa--we9y0tJ7TvHO961F5SwjeJ7ypdca4HR3Ze468ujY9T90u722l3T7n5rd7ItnTxFL8MOwvPKH88NEHugtlHaQvl7-z-xPwFyxYu_</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Dong, Fuxing</creator><creator>Liu, Yaping</creator><creator>Yan, Weixing</creator><creator>Meng, Qiqi</creator><creator>Song, Xueli</creator><creator>Cheng, Bing</creator><creator>Yao, Ruiqin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8544-824X</orcidid><orcidid>https://orcid.org/0000-0002-5132-3809</orcidid><orcidid>https://orcid.org/0000-0002-8845-7544</orcidid><orcidid>https://orcid.org/0000-0003-0430-3124</orcidid><orcidid>https://orcid.org/0000-0002-1412-2223</orcidid><orcidid>https://orcid.org/0000-0003-1729-3164</orcidid><orcidid>https://orcid.org/0000-0001-7617-5438</orcidid></search><sort><creationdate>20230701</creationdate><title>Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors</title><author>Dong, Fuxing ; Liu, Yaping ; Yan, Weixing ; Meng, Qiqi ; Song, Xueli ; Cheng, Bing ; Yao, Ruiqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5b71edd48891365b5a6d63b1997e32d069e4f83b55d7c6f299f38ef6bcbedcdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiogenesis</topic><topic>Axon guidance</topic><topic>Axonogenesis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Explants</topic><topic>Laminin</topic><topic>Metastases</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Olfactory bulb</topic><topic>Review Paper</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Fuxing</creatorcontrib><creatorcontrib>Liu, Yaping</creatorcontrib><creatorcontrib>Yan, Weixing</creatorcontrib><creatorcontrib>Meng, Qiqi</creatorcontrib><creatorcontrib>Song, Xueli</creatorcontrib><creatorcontrib>Cheng, Bing</creatorcontrib><creatorcontrib>Yao, Ruiqin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular and molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Fuxing</au><au>Liu, Yaping</au><au>Yan, Weixing</au><au>Meng, Qiqi</au><au>Song, Xueli</au><au>Cheng, Bing</au><au>Yao, Ruiqin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors</atitle><jtitle>Cellular and molecular neurobiology</jtitle><stitle>Cell Mol Neurobiol</stitle><addtitle>Cell Mol Neurobiol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>43</volume><issue>5</issue><spage>1663</spage><epage>1683</epage><pages>1663-1683</pages><issn>0272-4340</issn><eissn>1573-6830</eissn><abstract>Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high correlation with the laminin β-chain and promoted the growth of neurites in cultured olfactory bulb explants. Subsequently, it was discovered that Netrin-4 is involved in regulating various physiological processes, including angiogenesis, the occurrence and metastasis of various tumors, and the development of the kidney and alveoli. This paper reviews the current research on Netrin-4 since its discovery and provides a theoretical basis for further research on the biological characteristics of Netrin-4.
Graphical Abstract
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| subjects | Angiogenesis Axon guidance Axonogenesis Biomedical and Life Sciences Biomedicine Cell Biology Explants Laminin Metastases Neurobiology Neurosciences Olfactory bulb Review Paper Tumors |
| title | Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors |
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