Inhibition of sodium-glucose cotransporter 2 suppresses renal stone formation

Nephrolithiasis is a common renal disease with no effective medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have diuretic and anti-inflammatory properties and could prevent nephrolithiasis. Here, we investigated the potential of SGLT2 inhibition against nephrol...

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Veröffentlicht in:	Pharmacological research 2022-12, Vol.186, p.106524-106524, Article 106524
Hauptverfasser:	Anan, Go, Hirose, Takuo, Kikuchi, Daisuke, Takahashi, Chika, Endo, Akari, Ito, Hiroki, Sato, Shigemitsu, Nakayama, Shingo, Hashimoto, Hideaki, Ishiyama, Katsuya, Kimura, Tomoyoshi, Takahashi, Kazuhiro, Sato, Makoto, Mori, Takefumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium oxalate Calcium Oxalate - metabolism Diabetes Mellitus Glucose Humans Inflammation Kidney Calculi - drug therapy Kidney Calculi - metabolism Kidney Calculi - prevention & control Male Mice Osteopontin Phlorhizin Phlorizin Rats Rats, Sprague-Dawley Renal injury SGLT2 Sodium Sodium-Glucose Transporter 2 Inhibitors - pharmacology Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
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