Recent Progress in Carrier‐Free Nanomedicine for Tumor Phototherapy
Safe and effective strategies are urgently needed to fight against the life‐threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy and surgery, exhibit suboptimal efficacy for malignant tumors owing to the serious side effects, drug r...
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| Veröffentlicht in: | Advanced healthcare materials 2023-02, Vol.12 (4), p.e2202307-n/a |
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| description | Safe and effective strategies are urgently needed to fight against the life‐threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy and surgery, exhibit suboptimal efficacy for malignant tumors owing to the serious side effects, drug resistance and even relapse. Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), are emerging therapeutic strategies for localized tumor inhibition, which can produce a large amount of reactive oxygen species (ROS) or elevate the temperature to initiate cell death by non‐invasive irradiation. In consideration of the poor bioavailability of phototherapy agents (PTAs), lots of drug delivery systems have been developed to enhance the tumor targeted delivery. Nevertheless, the carriers of drug delivery systems inevitably bring biosafety concerns on account of their metabolism, degradation, and accumulation. Of note, carrier‐free nanomedicine attracts great attention for clinical translation with synergistic antitumor effect, which is characterized by high drug loading, simplified synthetic method and good biocompatibility. In this review, the latest advances of phototherapy with various carrier‐free nanomedicines are summarized, which may provide a new paradigm for the future development of nanomedicine and tumor precision therapy.
In this review, the latest trends of carrier‐free nanomedicines for tumor phototherapy are summarized. Moreover, the advantages and challenges of carrier‐free nanomedicines are also discussed, which may provide a new paradigm for the future development of nanomedicine and tumor precision therapy. |
| doi_str_mv | 10.1002/adhm.202202307 |
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In this review, the latest trends of carrier‐free nanomedicines for tumor phototherapy are summarized. Moreover, the advantages and challenges of carrier‐free nanomedicines are also discussed, which may provide a new paradigm for the future development of nanomedicine and tumor precision therapy.</description><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>carrier‐free nanomedicines</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drug resistance</subject><subject>Humans</subject><subject>Light therapy</subject><subject>Nanomedicine</subject><subject>Nanotechnology</subject><subject>Neoplasms - drug therapy</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Phototherapy</subject><subject>Radiation therapy</subject><subject>Reactive oxygen species</subject><subject>self‐assembly</subject><subject>Side effects</subject><subject>Theranostic Nanomedicine</subject><subject>tumor phototherapy</subject><subject>Tumors</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9Kw0AQhxdRrNRePUrAi5fW_Zds9lhqa4WqReo5bLITm5Jk626C9OYj-Iw-iVtaK3hxGXbm8M2P4UPoguABwZjeKL2sBhRTXwyLI3RGiaR9GoXy-DBz3EE951bYvygkUUxOUYdFjMuY8zM0foYM6iaYW_NqwbmgqIORsrYA-_XxObEAwaOqTQW6yIoagtzYYNFW_p8vTWOaJVi13pyjk1yVDnr73kUvk_FiNO3Pnu7uR8NZP2OYiX6olYwZ1kLkSoMWPMyxUoTnmgkuIFWpjgVOwzxMwwxAp2nEMh1LybHKSCRYF13vctfWvLXgmqQqXAZlqWowrUuoYDwiHBPi0as_6Mq0tvbXeUpQKajA3FODHZVZ45yFPFnbolJ2kxCcbB0nW8fJwbFfuNzHtqmXcsB_jHpA7oD3ooTNP3HJ8Hb68Bv-DR7RiK4</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Zhong, Ying‐Tao</creator><creator>Cen, Yi</creator><creator>Xu, Lin</creator><creator>Li, Shi‐Ying</creator><creator>Cheng, Hong</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3560-4432</orcidid></search><sort><creationdate>20230201</creationdate><title>Recent Progress in Carrier‐Free Nanomedicine for Tumor Phototherapy</title><author>Zhong, Ying‐Tao ; Cen, Yi ; Xu, Lin ; Li, Shi‐Ying ; Cheng, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3037-5da9830d77faded745f0aa14fd3747ebabd870b5f5b5ceedbb63cd89940ac1673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Bioavailability</topic><topic>Biocompatibility</topic><topic>carrier‐free nanomedicines</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Drug resistance</topic><topic>Humans</topic><topic>Light therapy</topic><topic>Nanomedicine</topic><topic>Nanotechnology</topic><topic>Neoplasms - drug therapy</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Phototherapy</topic><topic>Radiation therapy</topic><topic>Reactive oxygen species</topic><topic>self‐assembly</topic><topic>Side effects</topic><topic>Theranostic Nanomedicine</topic><topic>tumor phototherapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Ying‐Tao</creatorcontrib><creatorcontrib>Cen, Yi</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Li, Shi‐Ying</creatorcontrib><creatorcontrib>Cheng, Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Ying‐Tao</au><au>Cen, Yi</au><au>Xu, Lin</au><au>Li, Shi‐Ying</au><au>Cheng, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent Progress in Carrier‐Free Nanomedicine for Tumor Phototherapy</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>12</volume><issue>4</issue><spage>e2202307</spage><epage>n/a</epage><pages>e2202307-n/a</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Safe and effective strategies are urgently needed to fight against the life‐threatening diseases of various cancers. However, traditional therapeutic modalities, such as radiotherapy, chemotherapy and surgery, exhibit suboptimal efficacy for malignant tumors owing to the serious side effects, drug resistance and even relapse. Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), are emerging therapeutic strategies for localized tumor inhibition, which can produce a large amount of reactive oxygen species (ROS) or elevate the temperature to initiate cell death by non‐invasive irradiation. In consideration of the poor bioavailability of phototherapy agents (PTAs), lots of drug delivery systems have been developed to enhance the tumor targeted delivery. Nevertheless, the carriers of drug delivery systems inevitably bring biosafety concerns on account of their metabolism, degradation, and accumulation. 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In this review, the latest trends of carrier‐free nanomedicines for tumor phototherapy are summarized. Moreover, the advantages and challenges of carrier‐free nanomedicines are also discussed, which may provide a new paradigm for the future development of nanomedicine and tumor precision therapy.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36349844</pmid><doi>10.1002/adhm.202202307</doi><tpages>32</tpages><orcidid>https://orcid.org/0000-0002-3560-4432</orcidid></addata></record> |
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| subjects | Anticancer properties Antitumor activity Bioavailability Biocompatibility carrier‐free nanomedicines Cell death Cell Line, Tumor Chemotherapy Drug delivery Drug Delivery Systems Drug resistance Humans Light therapy Nanomedicine Nanotechnology Neoplasms - drug therapy Photochemotherapy Photodynamic therapy Phototherapy Radiation therapy Reactive oxygen species self‐assembly Side effects Theranostic Nanomedicine tumor phototherapy Tumors |
| title | Recent Progress in Carrier‐Free Nanomedicine for Tumor Phototherapy |
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