Effects of a New Natural Catechol‑O‑methyl Transferase Inhibitor on Two In Vivo Models of Parkinson’s Disease

A tetrahydroisoquinoline identified in Mucuna pruriens ((1R,3S)-6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline-1,3-dicarboxylic acid, compound 4) was synthesized and assessed for its in vitro pharmacological profile and in vivo effects in two animal models of Parkinson’s disease. Compound 4 i...

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Veröffentlicht in:	ACS chemical neuroscience 2022-12, Vol.13 (23), p.3303-3313
Hauptverfasser:	Parrales-Macias, Valeria, Harfouche, Abha, Ferrié, Laurent, Haïk, Stéphane, Michel, Patrick P., Raisman-Vozari, Rita, Figadère, Bruno, Bizat, Nicolas, Maciuk, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans Catechol O-Methyltransferase Levodopa - pharmacology Levodopa - therapeutic use Parkinson Disease - drug therapy Personality Rats
Online-Zugang:	Volltext
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