Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4

Endocardial cells lining the heart lumen are coronary vessel progenitors during embryogenesis. Re-igniting this developmental process in adults could regenerate blood vessels lost during cardiac injury, but this requires additional knowledge of molecular mechanisms. Here, we use mouse genetics and s...

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Veröffentlicht in:	Developmental cell 2022-11, Vol.57 (22), p.2517-2532.e6
Hauptverfasser:	D’Amato, Gaetano, Phansalkar, Ragini, Naftaly, Jeffrey A., Fan, Xiaochen, Amir, Zhainib A., Rios Coronado, Pamela E., Cowley, Dale O., Quinn, Kelsey E., Sharma, Bikram, Caron, Kathleen M., Vigilante, Alessandra, Red-Horse, Kristy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMP2 and Cxcl12/Cxc4 signaling Bone Morphogenetic Protein 2 Cell Differentiation Coronary Vessels Endocardium Endothelial Cells Female Heart heart regeneration Mice Organogenesis Pregnancy
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