Single Atom Ring Contraction of Peptide Macrocycles Using Cornforth Rearrangement

Site‐selective transformations of densely functionalized scaffolds have been a topic of intense interest in chemical synthesis. Herein we have repurposed the rarely used Cornforth rearrangement as a tool to effect a single‐atom ring contraction in cyclic peptide backbones. Investigations into the ki...

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Veröffentlicht in:	Angewandte Chemie International Edition 2023-01, Vol.62 (5), p.e202214729-n/a
Hauptverfasser:	Huh, Sungjoon, Saunders, George J., Yudin, Andrei K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical activity Chemical synthesis Conformation Conformational Analysis Cyclic Peptides Heterocycle Rearrangement Kinetics Macrocycles Molecular Conformation Peptides Peptides - chemistry Peptides, Cyclic - chemistry Ring Contraction Substrates
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