Investigation of isoflavone constituents from tuber of Apios americana Medik and its protective effect against oxidative damage on RIN-m5F cells

•Eleven main compounds were purified, identified and quantified from AI-3.•HMG has the strongest protective effect against H2O2-induced RIN-m5F cells injury.•HMG protect β-cell from H2O2 damage through Keap1-Nrf2 -ARE signaling pathway.•HMG up-regulated the expression of HOX-1, GST, NQO1, SQSTM, HO-...

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Veröffentlicht in:	Food chemistry 2023-03, Vol.405, p.134655-134655, Article 134655
Hauptverfasser:	Zhou, Weiying, Yang, Liangyuan, Deng, Ke, Xu, Guangzhi, Wang, Yan, Ni, Qinxue, Zhang, Youzuo
Format:	Artikel
Sprache:	eng
Schlagworte:	2′-Hydroxy-5-methoxy genistein-7-O-glucoside AI-3 Apios americana Apios americana Medik atherosclerosis food chemistry gene expression regulation hepatoma isoflavones Keap1-Nrf2-ARE pathway protective effect RIN-m5F cells RNA-seq sequence analysis shear stress
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