An endogenous inhibitor of angiogenesis downregulated by hypoxia in human aortic valve stenosis promotes disease pathogenesis

Aortic valve stenosis is the most common valve disease in the western world. Central to the pathogenesis of this disease is the growth of new blood vessels (angiogenesis) within the aortic valve allowing infiltration of immune cells and development of intra-valve inflammation. Identifying the cellul...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2023-01, Vol.174, p.25-37
Hauptverfasser:	Lewis, Christopher T.A., Mascall, Keith S., Wilson, Heather M., Murray, Fiona, Kerr, Keith M., Gibson, George, Buchan, Keith, Small, Gary R., Nixon, Graeme F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Aortic Valve - pathology Aortic valve stenosis Aortic Valve Stenosis - metabolism Humans Hypoxia Hypoxia - metabolism Inflammation - pathology Neovascularisation Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism
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