A NIR Fluorescent Probe Benzopyrylium Perchlorate-based for Visual Sensing and Imaging of SO2 Derivatives in Living Cells
Endogenous sulfur dioxide (SO 2 ), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO 2 in human physiology and pathology is of great significance to the biological characteristics of SO 2 ,which bring challenges to develop fluorescent probes wit...
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| Veröffentlicht in: | Journal of fluorescence 2023, Vol.33 (1), p.191-199 |
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| creator | Luo, Xiao Ye Xie, Juan Zhao, Guang Lian Li, Gui Yong Da Qu, Hang Yang, Yu Zhu |
| description | Endogenous sulfur dioxide (SO
2
), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO
2
in human physiology and pathology is of great significance to the biological characteristics of SO
2
,which bring challenges to develop fluorescent probes with excellent performance. Herein, we rationally designed and constructed a novel near-infrared bioprobe benzaldehyde-benzopyrylium (BBp) by employing the nucleophilic addition benzopyrylium perchlorate fluorophore and benzaldehyde moiety by means of C = C/C = O group that serves as both fluorescence reporting unit. Probe BBp exhibit excellent sensing performance with fluorescent “On − Off”rapid response (100 s) and long-wavelength emission (670 nm). With the treatment of HSO
3
−
, the color of BBp solution obviously varies from purple to colorless, and the fluorescent color varies from red to colorless. By the fluorescence and colorimetric changes, probe BBp was capable of sensitive determination HSO
3
−
with low limits of detection (LOD) of 0.43 μM, realizing visual quantitative monitoring SO
2
derivative levels. Due to the low phototoxicity and good biocompatibility, it was successfully applied to monitor SO
2
derivatives and fluorescence imaging in HepG2 and HeLa living cells. Hopefully, this work supplies a new strategy for designing NIR fluorescent probes for quantitative determination SO
2
derivatives in biological samples.
Graphical Abstract |
| doi_str_mv | 10.1007/s10895-022-03050-w |
| format | Article |
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2
), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO
2
in human physiology and pathology is of great significance to the biological characteristics of SO
2
,which bring challenges to develop fluorescent probes with excellent performance. Herein, we rationally designed and constructed a novel near-infrared bioprobe benzaldehyde-benzopyrylium (BBp) by employing the nucleophilic addition benzopyrylium perchlorate fluorophore and benzaldehyde moiety by means of C = C/C = O group that serves as both fluorescence reporting unit. Probe BBp exhibit excellent sensing performance with fluorescent “On − Off”rapid response (100 s) and long-wavelength emission (670 nm). With the treatment of HSO
3
−
, the color of BBp solution obviously varies from purple to colorless, and the fluorescent color varies from red to colorless. By the fluorescence and colorimetric changes, probe BBp was capable of sensitive determination HSO
3
−
with low limits of detection (LOD) of 0.43 μM, realizing visual quantitative monitoring SO
2
derivative levels. Due to the low phototoxicity and good biocompatibility, it was successfully applied to monitor SO
2
derivatives and fluorescence imaging in HepG2 and HeLa living cells. Hopefully, this work supplies a new strategy for designing NIR fluorescent probes for quantitative determination SO
2
derivatives in biological samples.
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2
), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO
2
in human physiology and pathology is of great significance to the biological characteristics of SO
2
,which bring challenges to develop fluorescent probes with excellent performance. Herein, we rationally designed and constructed a novel near-infrared bioprobe benzaldehyde-benzopyrylium (BBp) by employing the nucleophilic addition benzopyrylium perchlorate fluorophore and benzaldehyde moiety by means of C = C/C = O group that serves as both fluorescence reporting unit. Probe BBp exhibit excellent sensing performance with fluorescent “On − Off”rapid response (100 s) and long-wavelength emission (670 nm). With the treatment of HSO
3
−
, the color of BBp solution obviously varies from purple to colorless, and the fluorescent color varies from red to colorless. By the fluorescence and colorimetric changes, probe BBp was capable of sensitive determination HSO
3
−
with low limits of detection (LOD) of 0.43 μM, realizing visual quantitative monitoring SO
2
derivative levels. Due to the low phototoxicity and good biocompatibility, it was successfully applied to monitor SO
2
derivatives and fluorescence imaging in HepG2 and HeLa living cells. Hopefully, this work supplies a new strategy for designing NIR fluorescent probes for quantitative determination SO
2
derivatives in biological samples.
Graphical Abstract</description><subject>Analytical Chemistry</subject><subject>Benzaldehyde</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biological and Medical Physics</subject><subject>Biological properties</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Cells (biology)</subject><subject>Color</subject><subject>Colorimetry</subject><subject>Fluorescent indicators</subject><subject>Near infrared radiation</subject><subject>Sulfur dioxide</subject><issn>1053-0509</issn><issn>1573-4994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrGzEQhZfSQNOkfyAnQS-9qBlJK-3u0XXjxmCSkKS5Cnl37MrIkivt2ji_PnJcKOSQ0zxmvjfM8IrigsF3BlBdJgZ1IylwTkGABLr7UJwyWQlaNk35MWuQguZB86n4nNIKAJq6rE-L_YjcTO_JxA0hYmrR9-QuhjmSH-ifw2Yf984Oa3KHsf3jQjQ90rlJ2JFFiOTJpsE48oA-Wb8kxndkujbLgw4L8nDLyU-Mdmt6u8VErCczuz0Mx-hcOi9OFsYl_PKvnhW_J1eP42s6u_01HY9mtBVc9VRUKFXDSmNkOy-lkUzVLVdcdgY7OecVb6tGIa9LmWUjseUMVG4Y1QklQZwV3457NzH8HTD1em3zo84Zj2FImleCy5IDlxn9-gZdhSH6fF2mKqYqWcKB4keqjSGliAu9iXZt4l4z0Ic09DENndPQr2noXTaJoyll2C8x_l_9jusFTWSMiw</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Luo, Xiao Ye</creator><creator>Xie, Juan</creator><creator>Zhao, Guang Lian</creator><creator>Li, Gui Yong</creator><creator>Da Qu, Hang</creator><creator>Yang, Yu Zhu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2023</creationdate><title>A NIR Fluorescent Probe Benzopyrylium Perchlorate-based for Visual Sensing and Imaging of SO2 Derivatives in Living Cells</title><author>Luo, Xiao Ye ; Xie, Juan ; Zhao, Guang Lian ; Li, Gui Yong ; Da Qu, Hang ; Yang, Yu Zhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-37e56914aa5cb45a5168c2625daed5b272c796e284572c95ec21066e2a6d36503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analytical Chemistry</topic><topic>Benzaldehyde</topic><topic>Biochemistry</topic><topic>Biocompatibility</topic><topic>Biological and Medical Physics</topic><topic>Biological properties</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Cells (biology)</topic><topic>Color</topic><topic>Colorimetry</topic><topic>Fluorescent indicators</topic><topic>Near infrared radiation</topic><topic>Sulfur dioxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Xiao Ye</creatorcontrib><creatorcontrib>Xie, Juan</creatorcontrib><creatorcontrib>Zhao, Guang Lian</creatorcontrib><creatorcontrib>Li, Gui Yong</creatorcontrib><creatorcontrib>Da Qu, Hang</creatorcontrib><creatorcontrib>Yang, Yu Zhu</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of fluorescence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Xiao Ye</au><au>Xie, Juan</au><au>Zhao, Guang Lian</au><au>Li, Gui Yong</au><au>Da Qu, Hang</au><au>Yang, Yu Zhu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A NIR Fluorescent Probe Benzopyrylium Perchlorate-based for Visual Sensing and Imaging of SO2 Derivatives in Living Cells</atitle><jtitle>Journal of fluorescence</jtitle><stitle>J Fluoresc</stitle><date>2023</date><risdate>2023</risdate><volume>33</volume><issue>1</issue><spage>191</spage><epage>199</epage><pages>191-199</pages><issn>1053-0509</issn><eissn>1573-4994</eissn><abstract>Endogenous sulfur dioxide (SO
2
), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO
2
in human physiology and pathology is of great significance to the biological characteristics of SO
2
,which bring challenges to develop fluorescent probes with excellent performance. Herein, we rationally designed and constructed a novel near-infrared bioprobe benzaldehyde-benzopyrylium (BBp) by employing the nucleophilic addition benzopyrylium perchlorate fluorophore and benzaldehyde moiety by means of C = C/C = O group that serves as both fluorescence reporting unit. Probe BBp exhibit excellent sensing performance with fluorescent “On − Off”rapid response (100 s) and long-wavelength emission (670 nm). With the treatment of HSO
3
−
, the color of BBp solution obviously varies from purple to colorless, and the fluorescent color varies from red to colorless. By the fluorescence and colorimetric changes, probe BBp was capable of sensitive determination HSO
3
−
with low limits of detection (LOD) of 0.43 μM, realizing visual quantitative monitoring SO
2
derivative levels. Due to the low phototoxicity and good biocompatibility, it was successfully applied to monitor SO
2
derivatives and fluorescence imaging in HepG2 and HeLa living cells. Hopefully, this work supplies a new strategy for designing NIR fluorescent probes for quantitative determination SO
2
derivatives in biological samples.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10895-022-03050-w</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analytical Chemistry Benzaldehyde Biochemistry Biocompatibility Biological and Medical Physics Biological properties Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Cells (biology) Color Colorimetry Fluorescent indicators Near infrared radiation Sulfur dioxide |
| title | A NIR Fluorescent Probe Benzopyrylium Perchlorate-based for Visual Sensing and Imaging of SO2 Derivatives in Living Cells |
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