PTPRU, a quiescence-induced receptor tyrosine phosphatase negatively regulates osteogenic differentiation of human mesenchymal stem cells

Bone marrow mesenchymal stem cells (MSCs) are heterogeneous osteo-progenitors that are mainly responsible for bone regeneration and homeostasis. In vivo, a subpopulation of bone marrow MSCs persists in a quiescent state, providing a source of new cells for repair. Previously, we reported that induct...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-12, Vol.636 (Pt 1), p.41-49
Hauptverfasser:	Rumman, Mohammad, Dhawan, Jyotsna
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Cell Differentiation Cells, Cultured Differentiation Human MSC Humans Mesenchymal Stem Cells Osteogenesis Osteogenesis - genetics Phosphoric Monoester Hydrolases - metabolism PTPRU Quiescence Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism Tyrosine - metabolism Wnt Signaling Pathway - genetics
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