TGF-β3 enhances cell-to-cell communication in chondrocytes via the ALK5/p-Smad3 axis

Gap junctional intercellular communication (GJIC) is indispensable for the maintenance of physiological balance in articular cartilage. Transforming growth factor-β3 (TGF-β3), an important growth factor of TGF-β superfamily, is well recognized to play a unique regulatory role in cartilage developmen...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-12, Vol.636 (Pt 1), p.64-74
Hauptverfasser:	Cai, Lang, Pi, Caixia, Guo, Daimo, Li, Jiazhou, Chen, Hao, Zhang, Demao, Zhou, Xuedong, Xie, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	ALK5 Cartilage, Articular - metabolism Cell Communication Chondrocyte Chondrocytes - metabolism Connexin43 Gap junctional intercellular communication Gap Junctions - metabolism p-Smad3 signalling Receptor, Transforming Growth Factor-beta Type I - metabolism TGF-β3 Transforming Growth Factor beta3 - metabolism Transforming Growth Factor beta3 - pharmacology
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