Novel naturally occurring autoantibodies attenuate α‐synuclein pathology in a mouse model of Parkinson's disease

Aims Accumulation and propagation of pathological α‐synuclein (α‐Syn) are the major contributing factors to the pathogenesis of Parkinson's disease (PD). Therapy to halt the spreading of α‐Syn pathology needs to be established. Methods After phage display and affinity maturation, human‐derived...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2023-02, Vol.49 (1), p.e12860-n/a
Hauptverfasser:	Li, Yiming, Wang, Tao, Meng, Lanxia, Jin, Lei, Liu, Congcong, Liang, Yangqiu, Ren, Lin, Liu, Yang, Liu, Yanshuang, Liu, Shuang, Li, Tete, Liang, Yanqi, Chen, Xiaoping, Zhang, Zhentao
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Animal models Animals anti‐α‐Syn autoantibodies Autoantibodies Autoantibodies - metabolism Axons Brain - pathology Cyclin-dependent kinase inhibitor p21 Degeneration Disease Models, Animal Fibrillogenesis Fibrils Humans immunotherapy Lewy bodies Mice Movement disorders Neurodegenerative diseases Parkinson Disease - pathology Parkinson's disease Pathology Phage display Protein seeding Synuclein Synucleinopathies
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